Dietary ω-3 fatty acids and their influence on inflammation via Toll-like receptor pathways

Jalili, Mahsa; Hekmatdoost, Azita

doi:10.1016/j.nut.2020.111070

Cited by 22 publications

(15 citation statements)

References 87 publications

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“…Documented improvement in disease progression using antioxidants demonstrates the importance of antioxidants in reducing oxidative stress [70,71]. Furthermore, the [9] Parke DV, Sapota A.…”

Section: Ijbpas August 2019 8(8)mentioning

confidence: 99%

Serum and Synovial Fluid Oxidants and Antioxidants as Risk Factors in Rheumatoid Arthritis Patients

2019

IJBPAS

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Rheumatoid arthritis (RA) is a chronic autoimmune disorder of unknown etiology. Studies indicate that RA is related to the oxidative damage caused by reactive oxygen species, but results have been inconsistent. The aim of this study is to measure the oxidant levels (xanthine oxidase and malondialdehyde) and antioxidant levels (enzymatic superoxide dismutase, catalase and nonenzymatic vitamin E) in the serum and synovial fluid of RA patients. Serum and synovial fluid samples from 146 patients (68 males and 78 females) with active RA and serum samples from 136 healthy volunteers (65 males and 71 females) set as control were collected. The level of oxidants and antioxidants were measured. RA patients had significantly higher mean serum xanthine oxidase and malonaldehyde levels, while levels of superoxide dismutase, catalase and vitamin E were significantly lower when compared to control. Female RA patients had

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“…Documented improvement in disease progression using antioxidants demonstrates the importance of antioxidants in reducing oxidative stress [70,71]. Furthermore, the [9] Parke DV, Sapota A.…”

Section: Ijbpas August 2019 8(8)mentioning

confidence: 99%

Serum and Synovial Fluid Oxidants and Antioxidants as Risk Factors in Rheumatoid Arthritis Patients

2019

IJBPAS

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“…ω -3 PUFAs can inhibit the activation of epidermal growth factor receptor (EGFR), thereby inhibiting the phosphorylation of growth factor receptor-binding protein 2 (Grb2), and play a role in inflammation inhibition [ 30 ]. ω -3 PUFAs can also inhibit inflammation by inhibiting toll-like receptors, downregulating the NF- κ B signaling pathway, and reducing the expression of inflammatory genes [ 31 ]. Mocellin et al showed that ω -3 PUFAs reduced CRP levels in patients compared with controls [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of ω-3 Polyunsaturated Fatty Acids in Patients with Lung Cancer Undergoing Radiotherapy and Chemotherapy: A Meta-Analysis

Xin

Zhou

Rao

2022

International Journal of Clinical Practice

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Background. Radiotherapy and chemotherapy in patients with lung cancer can lead to a series of problems such as malnutrition and inflammatory reaction. Some studies have shown that ω-3 polyunsaturated fatty acids (PUFAs) could improve malnutrition and regulate inflammatory reaction in these patients, but no relevant meta-analysis exists. Methods. We systematically searched randomized controlled trials of ω-3 PUFAs in the adjuvant treatment of lung cancer in the PubMed, EMBASE, Cochrane Library, Web of Science, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), and Wanfang databases. Relevant outcomes were extracted, and we pooled standardized mean differences (SMDs) using a random or fixed-effects model. The risk of bias was evaluated according to the Cochrane Handbook (version 15.1). The quality of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Results. A total of 7 studies were included. The SMDs (95% CI) of body weight change, albumin change, energy intake, and protein intake at the end of intervention were 1.15 (0.50, 1.80), 0.60 (0.11, 1.09), 0.39 (−0.10, 0.89), and 0.27 (−0.04, 0.58), respectively. The SMDs (95% CI) of CRP change and TNF-α change were −3.44 (−6.15, −0.73) and −1.63 (−2.53, −0.73), respectively. Conclusions. ω-3 PUFAs can improve nutritional status and regulate indicators of inflammation in patients with lung cancer undergoing radiotherapy and chemotherapy. This study was registered in the PROSPERO (registration number: CRD42022307699).

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“…Omega-3 PUFAs can act as agonist ligands for G protein-coupled receptor 40 (GPR40) and G protein-coupled receptor 120 (GPR120), peroxisome proliferator-activated receptors (PPARs) and retinoid X receptor α (RXRA). In addition, omega-3 PUFAs can also downregulate nuclear factor kappa-B (NF-κB) through their inhibitory effects on toll-like receptor 4 (TLR4) or binding to peroxisome proliferator-activated receptor-γ (PPARγ) ( 29 – 31 ). Omega-3 PUFAs may exert neurological benefits through activating corresponding receptors such as GPR120, GPR40 as well as PPARs ( 23 ).…”

Section: The Cellular and Molecular Basis Of Omega-3 Pufasmentioning

confidence: 99%

Possible antidepressant mechanisms of omega-3 polyunsaturated fatty acids acting on the central nervous system

et al. 2022

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Omega-3 polyunsaturated fatty acids (PUFAs) can play important roles in maintaining mental health and resistance to stress, and omega-3 PUFAs supplementation can display beneficial effects on both the prevention and treatment of depressive disorders. Although the underlying mechanisms are still unclear, accumulated evidence indicates that omega-3 PUFAs can exhibit pleiotropic effects on the neural structure and function. Thus, they play fundamental roles in brain activities involved in the mood regulation. Since depressive symptoms have been assumed to be of central origin, this review aims to summarize the recently published studies to identify the potential neurobiological mechanisms underlying the anti-depressant effects of omega-3 PUFAs. These include that of (1) anti-neuroinflammatory; (2) hypothalamus-pituitary-adrenal (HPA) axis; (3) anti-oxidative stress; (4) anti-neurodegeneration; (5) neuroplasticity and synaptic plasticity; and (6) modulation of neurotransmitter systems. Despite many lines of evidence have hinted that these mechanisms may co-exist and work in concert to produce anti-depressive effects, the potentially multiple sites of action of omega-3 PUFAs need to be fully established. We also discussed the limitations of current studies and suggest future directions for preclinical and translational research in this field.

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Dietary ω-3 fatty acids and their influence on inflammation via Toll-like receptor pathways

Cited by 22 publications

References 87 publications

Serum and Synovial Fluid Oxidants and Antioxidants as Risk Factors in Rheumatoid Arthritis Patients

Serum and Synovial Fluid Oxidants and Antioxidants as Risk Factors in Rheumatoid Arthritis Patients

Efficacy of ω-3 Polyunsaturated Fatty Acids in Patients with Lung Cancer Undergoing Radiotherapy and Chemotherapy: A Meta-Analysis

Possible antidepressant mechanisms of omega-3 polyunsaturated fatty acids acting on the central nervous system

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