DietaryAdvancedGlycationEnd Products–InducedCognitive Impairment in Aged ICR Mice: Protective Role of Quercetin

Yang, Shengyi; Wang, Guiping; Feei, Zheng; Qin, Liqiang; Zhai, Yujia; Yu, Zengli; Xue, Mingzhu; Zhang, Yahan; Wan, Zhongxiao

doi:10.1002/mnfr.201901019

Cited by 41 publications

(47 citation statements)

References 47 publications

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“…Quercetin [116], resveratrol [117] and ferulic acid [118] are other polyphenolic compounds isolated from vegetables and fruits with beneficial properties for AD treatment via inhibiting Aβ production/aggregation, destabilizing Aβ fibrils, alleviating oxidative stress and inflammation. Quercetin [119] and resveratrol [120] also rescued cognitive deficits by suppressing tau phosphorylation. In addition, resveratrol has been safe and well-tolerated for mild to moderate AD patients in two randomized, double-blind, placebo-controlled trials with uncertain efficacy on clinical outcomes [121,122], while quercetin and ferulic acid are not studied in clinical trials so far.…”

Section: The Main Redox Signaling-associated Mechanisms and Their Cromentioning

confidence: 92%

Redox signaling and Alzheimer’s disease: from pathomechanism insights to biomarker discovery and therapy strategy

Chen

Wang²,

Wang

et al. 2020

Biomark Res

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Aging and average life expectancy have been increasing at a rapid rate, while there is an exponential risk to suffer from brain-related frailties and neurodegenerative diseases as the population ages. Alzheimer’s disease (AD) is the most common neurodegenerative disease worldwide with a projected expectation to blossom into the major challenge in elders and the cases are forecasted to increase about 3-fold in the next 40 years. Considering the etiological factors of AD are too complex to be completely understood, there is almost no effective cure to date, suggesting deeper pathomechanism insights are urgently needed. Metabolites are able to reflect the dynamic processes that are in progress or have happened, and metabolomic may therefore provide a more cost-effective and productive route to disease intervention, especially in the arena for pathomechanism exploration and new biomarker identification. In this review, we primarily focused on how redox signaling was involved in AD-related pathologies and the association between redox signaling and altered metabolic pathways. Moreover, we also expatiated the main redox signaling-associated mechanisms and their cross-talk that may be amenable to mechanism-based therapies. Five natural products with promising efficacy on AD inhibition and the benefit of AD intervention on its complications were highlighted as well. Graphical Abstract

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Section: The Main Redox Signaling-associated Mechanisms and Their Cromentioning

confidence: 92%

Redox signaling and Alzheimer’s disease: from pathomechanism insights to biomarker discovery and therapy strategy

Chen

Wang²,

Wang

et al. 2020

Biomark Res

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“…The results evaluating different biochemical pathways suggested that treatment by quercetin supplication has improved cognitive function in experimental animals. A similar study was carried out by Yang et al [103] by stating that extended application of quercetin may be beneficial for high consumers of dAGEs. The neurotoxicity by the exposure of pesticide fenitrothion has led Ibrahim et al [104], to carry out a study in rats for the role of quercetin against the development of such neurological impairment.…”

Section: Quercetin As a Neuroprotective Agentmentioning

confidence: 54%

Quercetin: A Bioactive Compound Imparting Cardiovascular and Neuroprotective Benefits: Scope for Exploring Fresh Produce, Their Wastes, and By-Products

Bhat

2021

Biology

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Quercetin, a bioactive secondary metabolite, holds incredible importance in terms of bioactivities, which has been proved by in vivo and in vitro studies. The treatment of cardiovascular and neurological diseases by quercetin has been extensively investigated over the past decade. Quercetin is present naturally in appreciable amounts in fresh produce (fruits and vegetables). However, today, corresponding to the growing population and global demand for fresh fruits and vegetables, a paradigm shift and focus is laid towards exploring industrial food wastes and/or byproducts as a new resource to obtain bioactive compounds such as quercetin. Based on the available research reports over the last decade, quercetin has been suggested as a reliable therapeutic candidate for either treating or alleviating health issues, mainly those of cardiovascular and neurological diseases. In the present review, we have summarized some of the critical findings and hypotheses of quercetin from the available databases foreseeing its future use as a potential therapeutic agent to treat cardiovascular and neurological diseases. It is anticipated that this review will be a potential reference material for future research activities to be undertaken on quercetin obtained from fresh produce as well as their respective processing wastes/byproducts that rely on the circular concept.

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“…To make high AGEs diet, the standard chow was baked at 180 ˚C for 60 min following a published method. [ 19,20 ] All diets were identical in macronutrients and calories, but HAGE diet contained more fluorescent AGEs (threefold), carboxymethyl lysine (CML; fivefold), and pentosidine (twofold) than LAGE diet (Table S1, Supporting Information). The mice were housed under a 12 h light/dark cycle with free access to food and water.…”

Section: Methodsmentioning

confidence: 99%

Pterostilbene Improves Insulin Resistance Caused by Advanced Glycation End Products (AGEs) in Hepatocytes and Mice

Fan

Wang

et al. 2021

Molecular Nutrition Food Res

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Scope Increased consumption of modern processed foods rich in AGEs is drawing worldwide concerns because they are related with rising diabetes prevalence. This study aimed to investigate if pterostilbene (PTE) regulates glucose metabolism and insulin signaling, as well as its potential mechanism in the context of AGEs exposure. Methods and Results In vitro, Lo2 and HepG2 cells are treated with vehicle, AGEs with or without PTE. AGEs exposure directly impair insulin action as evidenced by assays of insulin‐stimulated glucose uptake, consumption, and output. However, PTE efficiently rescue the AGE‐induced phenotypes in both cell lines, and enhance IRS‐1/PI3K/AKT insulin signaling in a dose‐dependent manner. In vivo, C57BL6 mice are fed with regular, high AGEs diet and high AGEs plus PTE. PTE administration effectively improves hyperglycemia, glucose tolerance, and impaired hepatic insulin signaling induced by AGEs, consistent with the in vitro experiments. Moreover, PTE reduce AGEs accumulation in liver and serum. RNA‐seq data indicate that PTE counteracts several AGEs‐induced dysfunctions including diabetes related process, glucose metabolic process, immune response, and so on. Conclusion PTE treatment prominently reduced AGEs accumulation and alleviated AGEs‐associated diabetes symptoms. PTE could be used as a promising glucose‐sensitizing agent for nutritional intervention.

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DietaryAdvancedGlycationEnd Products–InducedCognitive Impairment in Aged ICR Mice: Protective Role of Quercetin

Cited by 41 publications

References 47 publications

Redox signaling and Alzheimer’s disease: from pathomechanism insights to biomarker discovery and therapy strategy

Redox signaling and Alzheimer’s disease: from pathomechanism insights to biomarker discovery and therapy strategy

Quercetin: A Bioactive Compound Imparting Cardiovascular and Neuroprotective Benefits: Scope for Exploring Fresh Produce, Their Wastes, and By-Products

Pterostilbene Improves Insulin Resistance Caused by Advanced Glycation End Products (AGEs) in Hepatocytes and Mice

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