Diethylenetriamine/NONOate-doped alginate hydrogel with sustained nitric oxide release and minimal toxicity to accelerate healing of MRSA-infected wounds

Hasan, Nurhasni; Lee, Juho; Kwak, Dongmin; Kim, Hyun Woo; Saparbayeva, Aruzhan; Ahn, Hye‐Jin; Yoon, In‐Soo; Kim, Min‐Soo; Jung, Yunjin; Yoo, Jin‐Wook

doi:10.1016/j.carbpol.2021.118387

Cited by 46 publications

(21 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alginate (ALG) hydrogel doped with a NO donor, diethylenetriamine/diazeniumdiolate, was able to release NO over 4 days, and showed strong antibacterial activity against MRSA but only minute toxicity to mouse fibroblasts. This hydrogel exhibited reduced inflammation and rapid wound-size reduction along with improved re-epithelialization, angiogenesis, and collagen deposition, resulting in reduced skin bacterial infection in MRSA-infected wounds in a mouse model [ 224 ]. Amikacin and naproxen preloaded hydrogel fabricated via grafting phenylboronic acid to the side chain of the ALG polymer, and showing dual-responsiveness of pH and ROS, exhibited antibacterial and anti-inflammatory properties.…”

Section: Applied Nanomaterialsmentioning

confidence: 99%

Advances in Nanostructures for Antimicrobial Therapy

Jampílek

Kráľová

2022

Materials

View full text Add to dashboard Cite

Microbial infections caused by a variety of drug-resistant microorganisms are more common, but there are fewer and fewer approved new antimicrobial chemotherapeutics for systemic administration capable of acting against these resistant infectious pathogens. Formulation innovations of existing drugs are gaining prominence, while the application of nanotechnologies is a useful alternative for improving/increasing the effect of existing antimicrobial drugs. Nanomaterials represent one of the possible strategies to address this unfortunate situation. This review aims to summarize the most current results of nanoformulations of antibiotics and antibacterial active nanomaterials. Nanoformulations of antimicrobial peptides, synergistic combinations of antimicrobial-active agents with nitric oxide donors or combinations of small organic molecules or polymers with metals, metal oxides or metalloids are discussed as well. The mechanisms of actions of selected nanoformulations, including systems with magnetic, photothermal or photodynamic effects, are briefly described.

show abstract

Section: Applied Nanomaterialsmentioning

confidence: 99%

Advances in Nanostructures for Antimicrobial Therapy

Jampílek

Kráľová

2022

Materials

View full text Add to dashboard Cite

show abstract

“…An approach to counteract the formation of these undesired molecules has been explored and lies on the chemical attachment of diazeniumdiolates to a larger molecule (i.e., polymer). Under these conditions, some authors also hypothesize that the half-life of NONOates is altered and possibly prolonged [80]. decompose into the parent amine and two molecules of NO, making NO release a pHdependent process.…”

Section: S-nitrosothiolmentioning

confidence: 99%

Recent Advances in Hydrogel-Mediated Nitric Oxide Delivery Systems Targeted for Wound Healing Applications

2022

View full text Add to dashboard Cite

Despite the noticeable evolution in wound treatment over the centuries, a functional material that promotes correct and swift wound healing is important, considering the relative weight of chronic wounds in healthcare. Difficult to heal in a fashionable time, chronic wounds are more prone to infections and complications thereof. Nitric oxide (NO) has been explored for wound healing applications due to its appealing properties, which in the wound healing context include vasodilation, angiogenesis promotion, cell proliferation, and antimicrobial activity. NO delivery is facilitated by molecules that release NO when prompted, whose stability is ensured using carriers. Hydrogels, popular materials for wound dressings, have been studied as scaffolds for NO storage and delivery, showing promising results such as enhanced wound healing, controlled and sustained NO release, and bactericidal properties. Systems reported so far regarding NO delivery by hydrogels are reviewed.

show abstract

“…Reprinted and modified with permission from Ref. [ 129 ] Copyright 2021 Elsevier Ltd. and ( C ) Naphthalene conjugated short peptide, FFGGG and b-galactose caged nitric oxide (NO) donor (NapFF-NO) self-assembled hydrogel releasing NO in response to b-galactosidase to enhance the therapeutic efficacy of mesenchymal stem cells for myocardial infarction: ( i ) structure of NapFF-NO, ( ii ) NO release amount and ( iii ) Masson’s trichrome staining image of heart sections at Day 30 after treated with hydrogel. Reprinted and modified with permission from Ref.…”

Section: Injectable Rons-releasing Hydrogelsmentioning

confidence: 99%

Injectable reactive oxygen and nitrogen species-controlling hydrogels for tissue regeneration: current status and future perspectives

Thi

Tran

Thi

et al. 2022

Regenerative Biomaterials

View full text Add to dashboard Cite

The dual role of reactive oxygen and nitrogen species (RONS) in physiological and pathological processes in biological systems has been widely reported. It has been recently suggested that the regulation of RONS levels under physiological and pathological conditions is a potential therapy to promote health and treat diseases, respectively. Injectable hydrogels have been emerging as promising biomaterials for RONS-related biomedical applications owing to their excellent biocompatibility, 3-dimensional (3D) and extracellular matrix-mimicking structures, tunable properties, and easy functionalization. These hydrogels have been developed as advanced injectable platforms for locally generating or scavenging RONS, depending on the specific conditions of the target disease. In this review article, the design principles and mechanism by which RONS are generated/scavenged from hydrogels are outlined alongside a discussion of their in vitro and in vivo evaluations. Additionally, we highlight the advantages and recent developments of these injectable RONS-controlling hydrogels for regenerative medicines and tissue engineering applications.

show abstract

Diethylenetriamine/NONOate-doped alginate hydrogel with sustained nitric oxide release and minimal toxicity to accelerate healing of MRSA-infected wounds

Cited by 46 publications

References 35 publications

Advances in Nanostructures for Antimicrobial Therapy

Advances in Nanostructures for Antimicrobial Therapy

Recent Advances in Hydrogel-Mediated Nitric Oxide Delivery Systems Targeted for Wound Healing Applications

Injectable reactive oxygen and nitrogen species-controlling hydrogels for tissue regeneration: current status and future perspectives

Contact Info

Product

Resources

About