2019
DOI: 10.1371/journal.pone.0214756
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Diethylnitrosamine (DENA) recapitulates formation of hepatic angiosarcoma in pigs

Abstract: Background & aim Primary hepatic angiosarcoma is a rare tumor with poor prognosis. The aim of this study was to generate a new angiosarcoma model to improve research on hepatic angiosarcoma. Methods Pigs sus scrofa were treated with different regimens of diethylnitrosamine (DENA). Tissues were analyzed by histology and immunohistochemistry. Serum parameters were determined. Angiosarcoma tissue was investigated for chromosomal aberrations by aC… Show more

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Cited by 4 publications
(3 citation statements)
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“…The current study's tumor histopathology, notably the trabecular type of HCC and hepatic angiosarcoma, is consistent with prior findings in DENA-treated swine. 6,19 All of the HCCs detected in the current investigation were well differentiated rather than poorly differentiated, implying that dysplastic alterations progressed throughout time rather than becoming de novo carcinoma. 6,28 The high levels of immunopositivity for Hep Par-1, which reveals both normal and malignant hepatocytes, and Ki-67, which demonstrates cell proliferation, are consistent with earlier research on HCC in DENA-treated swine.…”
Section: Discussionmentioning
confidence: 81%
See 1 more Smart Citation
“…The current study's tumor histopathology, notably the trabecular type of HCC and hepatic angiosarcoma, is consistent with prior findings in DENA-treated swine. 6,19 All of the HCCs detected in the current investigation were well differentiated rather than poorly differentiated, implying that dysplastic alterations progressed throughout time rather than becoming de novo carcinoma. 6,28 The high levels of immunopositivity for Hep Par-1, which reveals both normal and malignant hepatocytes, and Ki-67, which demonstrates cell proliferation, are consistent with earlier research on HCC in DENA-treated swine.…”
Section: Discussionmentioning
confidence: 81%
“…A previous study with DENA-treated conventional domestic swine produced only mesenchymal tumors (hepatic angiosarcoma and leiomyoma) with no progression to HCC; the study used repeated DENA treatments without PB. 19 To the best of our knowledge, this is the first study using full-sized farm breed (conventional) domestic swine to induce HCC by administering DENA and PB. The successful induction of HCC in our study may be a milestone for other investigators aiming to develop large-animal models for medical research using widely available domestic swine.…”
Section: Discussionmentioning
confidence: 97%
“…The present study examined the in vivo effects of galangin plus luteolin, either alone or in combination with DOX, on HCC. The treatment of sus scrofa with 15 mg/kg DENA weekly produces a model for hepatic angiosarcoma that helps to discover new mechanisms of primary hepatic angiosarcoma and encourages treatment [ 28 ]. In the present study, liver integrity was estimated by measuring the serum levels of ALT, ALP, AST, and total bilirubin.…”
Section: Discussionmentioning
confidence: 99%