Diets Rich in Polyunsaturated Fatty Acids With Different Omega-6/Omega-3 Ratio Decrease Liver Content of Saturated Fatty Acids Across Generations of Wistar Rats

Abstract

Our study evaluated how the consumption of diets with low or high

In vivo monitoring of hepatic glycolipid distribution of <i>n</i>-6 ∕ <i>n</i>-3 in jugular-vein-cannulated rats as a nutritional research model for monogastric animal

“…Dietary fat could facilitate 438 S.-O. Park and V. A. Zammit: Glycolipid distribution of n-6 / n-3 in rats adaptation to lipid metabolism in the next generation of rats (Chambers et al, 2016;Halfen et al, 2016). Dietary intake with the ratio of n-6 / n-3 dropped to 8 : 1 or lower from parent generation to the next generation can reduce harmful lipid in the blood, and stimulate growth by activating the metabolism of nutrients (Shin et al, 2017).…”

The High ‘Lipolytic Jump’ of Immobilized Amano A Lipase from Aspergillus niger in Developed ‘ESS Catalytic Triangles’ Containing Natural Origin Substrates

“…Such a system could be applied to in vitro tests with the aim of fat digestion, especially of fats unfavorable to human health. As mentioned in the Introduction, a diet containing unsaturated fatty acids should be properly balanced, as an excess of ω6 PUFAs can be harmful to the organism [73]. Our results showed the high catalytic specificity of AA-ANL to ω6 PUFAs, which can be useful in the future to create a therapeutic system supporting the release of fat excess from the body.…”

“…Another advantage of LA is the possibility of its endogenous production in human organisms compared with EPA and DHA. On the other hand, excessive dietary consumption of LA can cause a fatty liver [73] Oleic acid (OA) is the main representative of ω9 MUFAs. Like LA, OA is an important energetic reservoir for the organism and exhibits antisclerotic activity.…”

“…As suggested by the authors of previous works [61,62], the ω6/ω3 PUFA supplementation system seems to be the most beneficial for the human organism. In contrast, the proportion of ω6 to ω3 PUFAs should not be high due to the previously mentioned risk of obesity associated with fatty liver [73]. With respect to dietary supplements containing PUFAs and MUFAs, MC-UFAs contain both and occur in vegetable oils, which are, together with fish oil, the main sources of PUFAs in the human diet.…”

Effects of blended oils with different n-6/n-3 polyunsaturated fatty acid ratios on high-fat diet-induced metabolic disorders and hepatic steatosis in rats

“…In the present study, the 1:1 and 5:1 groups had lower serum LPL levels than those in the 20:1, Lard, and NC groups, and the 1:1 and Lard groups had lower serum FFA concentrations compared with those in the 20:1 and NC groups. Halfen et al (2016) found that a low n-6/n-3 PUFA diet was more effective in reducing blood TG and FFA levels in Wistar rats compared with those of high n-6/n-3 PUFA diets. Chang et al (2014) reported that replacing SFAs in a high-fat diet with n-3 PUFAs reduced aortic LPL levels in LDLR -/mice.…”