Difenoconazole causes cardiotoxicity in common carp (Cyprinus carpio): Involvement of oxidative stress, inflammation, apoptosis and autophagy

Gao, Xuzhu; Liu, Feixue; FangWang,; Dong, Jingquan; Zhao, Panpan

doi:10.1016/j.chemosphere.2022.135562

Cited by 40 publications

(3 citation statements)

References 44 publications

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“…The study revealed that the mRNA and protein expressions of TLR2, COX2, TNF-α, tumor necrosis factor receptor-associated factor 6 (TRAF6), IL-1β, NF-κB, iNOS, and p65, were increased in hepatopancreas and hepatocytes of carp ( Cui et al, 2023 ). Wang et al (2022) found that extended exposure to polystyrene microplastics in loach juveniles ( Paramisgurnus dabryanus ) inhibited the expression of Keap1-Nrf2 signaling pathway genes in loach juveniles. Polystyrene microplastic exposure induced apoptosis by upregulating p53, gadd45ba, and caspase3b expressions.…”

Section: Microplastics Induced Oxidative Stress In Fishesmentioning

confidence: 97%

Effects of microplastics, pesticides and nano-materials on fish health, oxidative stress and antioxidant defense mechanism

Subaramaniyam,

Allimuthu,

Vappu

et al. 2023

Front. Physiol.

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Microplastics and pesticides are emerging contaminants in the marine biota, which cause many harmful effects on aquatic organisms, especially on fish. Fish is a staple and affordable food source, rich in animal protein, along with various vitamins, essential amino acids, and minerals. Exposure of fish to microplastics, pesticides, and various nanoparticles generates ROS and induces oxidative stress, inflammation, immunotoxicity, genotoxicity, and DNA damage and alters gut microbiota, thus reducing the growth and quality of fish. Changes in fish behavioral patterns, swimming, and feeding habits were also observed under exposures to the above contaminants. These contaminants also affect the Nrf-2, JNK, ERK, NF-κB, and MAPK signaling pathways. And Nrf2-KEAP1 signalling modulates redox status marinating enzymes in fish. Effects of pesticides, microplastics, and nanoparticles found to modulate many antioxidant enzymes, including superoxide dismutase, catalase, and glutathione system. So, to protect fish health from stress, the contribution of nano-technology or nano-formulations was researched. A decrease in fish nutritional quality and population significantly impacts on the human diet, influencing traditions and economics worldwide. On the other hand, traces of microplastics and pesticides in the habitat water can enter humans by consuming contaminated fish which may result in serious health hazards. This review summarizes the oxidative stress caused due to microplastics, pesticides and nano-particle contamination or exposure in fish habitat water and their impact on human health. As a rescue mechanism, the use of nano-technology in the management of fish health and disease was discussed.

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Section: Microplastics Induced Oxidative Stress In Fishesmentioning

confidence: 97%

Effects of microplastics, pesticides and nano-materials on fish health, oxidative stress and antioxidant defense mechanism

Subaramaniyam,

Allimuthu,

Vappu

et al. 2023

Front. Physiol.

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“…Recent studies have indicated that Sfrp2 promotes cardiac function and attenuates doxorubicin-induced cardiotoxicity by regulating the Akt/mTOR pathway [39]. Connective tissue growth factor (CTGF) and transforming growth factor β1 (TGFβ1), cytokines regulating cell proliferation, were found to be decreased in doxorubicininduced cardiotoxicity and were utilized to evaluate the absence of cardiovascular injury in NSCLC patients in our study [40,41].…”

Section: Introductionmentioning

confidence: 94%

Association between Cardiovascular Response and Inflammatory Cytokines in Non-Small Cell Lung Cancer Patients

Wang

Cao

Liu

et al. 2023

JCDD

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Cardiovascular disease is an essential comorbidity in patients with non-small cell lung cancer (NSCLC) and represents an independent risk factor for increased mortality. Therefore, careful monitoring of cardiovascular disease is crucial in the healthcare of NSCLC patients. Inflammatory factors have previously been associated with myocardial damage in NSCLC patients, but it remains unclear whether serum inflammatory factors can be utilized to assess the cardiovascular health status in NSCLC patients. A total of 118 NSCLC patients were enrolled in this cross-sectional study, and their baseline data were collected through a hospital electronic medical record system. Enzyme-linked immunosorbent assay (ELISA) was used to measure the serum levels of leukemia inhibitory factor (LIF), interleukin (IL)-18, IL-1β, transforming growth factor-β1 (TGF-β1), and connective tissue growth factor (CTGF). Statistical analysis was performed using the SPSS software. Multivariate and ordinal logistic regression models were constructed. The data revealed an increased serum level of LIF in the group using tyrosine kinase inhibitor (TKI)-targeted drugs compared to non-users (p < 0.001). Furthermore, serum TGF-β1 (area under the curve, AUC: 0.616) and cardiac troponin T (cTnT) (AUC: 0.720) levels were clinically evaluated and found to be correlated with pre-clinical cardiovascular injury in NSCLC patients. Notably, the serum levels of cTnT and TGF-β1 were found to indicate the extent of pre-clinical cardiovascular injury in NSCLC patients. In conclusion, the results suggest that serum LIF, as well as TGFβ1 together with cTnT, are potential serum biomarkers for the assessment of cardiovascular status in NSCLC patients. These findings offer novel insights into the assessment of cardiovascular health and underscore the importance of monitoring cardiovascular health in the management of NSCLC patients.

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“…Common carp ( Cyprinus carpio ) were selected as a candidate species to study the potential toxic effects of CPF and GLY in aquatic environments because common carp are a commonly used model for toxicological studies [ 24 , 25 ] and they are easily captured and important for human consumption. The brain is the central organ controlling the physiology of the animal and plays a crucial role in maintaining normal physiological processes, highlighting its importance in environmental risk assessments [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Single and Combined Effects of Chlorpyrifos and Glyphosate on the Brain of Common Carp: Based on Biochemical and Molecular Perspective

Zhang,

Ding,

Liu

et al. 2023

IJMS

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Chlorpyrifos (CPF) and glyphosate (GLY) are the most widely used organophosphate insecticide and herbicide worldwide, respectively; co-occurrence of CPF and GLY in aquatic environments occurs where they inevitably have potential hazards to fish. However, the potential mechanisms of CPF and GLY to induce toxicity have not been fully explored. To identify the adverse impacts of CPF and GLY on fish, either alone or in combination (MIX), CPF (25 μg/L) and GLY (3.5 mg/L) were set up according to an environmentally relevant concentration to expose to common carp for 21 days. After exposure, CPF and GLY decreased the activities of acetylcholinesterase and Na+/K+-ATPase, altered monoamine oxidase levels, decreased antioxidant enzyme activities (superoxide dismutase, catalase, glutathione S-transferase and glutamic reductase), and induced the accumulation of malondialdehyde in the carp brain. The parameters in the MIX groups had a greater impact compared to that in the CPF or GLY group, suggesting that both single and combined exposure could affect neurological signaling systems and cause oxidative stress and lipid peroxidation damage in carp brains, and that MIX exposure increases the impact of each pollutant. RNA-seq results showed that single or combined exposure to CPF and GLY induced global transcriptomic changes in fish brains, and the number of differentially expressed genes in MIX-treated carp brains were globally increased compared to either the CPF or GLY groups, suggesting that the effects of co-exposure were greater than single exposure. Further analysis results revealed that the global transcriptomic changes participated in oxidative stress, immune dysfunction, and apoptosis of fish brains, and identified that the P13k-Akt signaling pathway participates in both single and combined exposure of CPF- and GLY-induced toxicity. Taken together, our results demonstrated that the interaction of CPF and GLY might be synergic and provided novel insights into the molecular mechanisms of fish brains coping with CPF and GLY.

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Difenoconazole causes cardiotoxicity in common carp (Cyprinus carpio): Involvement of oxidative stress, inflammation, apoptosis and autophagy

Cited by 40 publications

References 44 publications

Effects of microplastics, pesticides and nano-materials on fish health, oxidative stress and antioxidant defense mechanism

Effects of microplastics, pesticides and nano-materials on fish health, oxidative stress and antioxidant defense mechanism

Association between Cardiovascular Response and Inflammatory Cytokines in Non-Small Cell Lung Cancer Patients

Single and Combined Effects of Chlorpyrifos and Glyphosate on the Brain of Common Carp: Based on Biochemical and Molecular Perspective

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