1988
DOI: 10.1016/s0140-6736(88)90997-x
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Difference Between Herpes Simplex Virus Type I and Type 2 Neonatal Encephalitis in Neurological Outcome

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Cited by 176 publications
(17 citation statements)
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“…In contrast, most infants with CNS disease had antibodies to their infecting viral type consistent with transplacental passage of maternal antibodies. The greater likelihood of detection of HSV antibodies at the time of diagnosis for infants with CNS disease has been noted in previous studies [3537]. An alternate explanation is that these infants are infected shortly after birth and have mounted their own antibody response by the time they become symptomatic with HSV encephalitis [38].…”
Section: Discussionmentioning
confidence: 82%
“…In contrast, most infants with CNS disease had antibodies to their infecting viral type consistent with transplacental passage of maternal antibodies. The greater likelihood of detection of HSV antibodies at the time of diagnosis for infants with CNS disease has been noted in previous studies [3537]. An alternate explanation is that these infants are infected shortly after birth and have mounted their own antibody response by the time they become symptomatic with HSV encephalitis [38].…”
Section: Discussionmentioning
confidence: 82%
“…Neonatal herpes encephalitis is a highly lethal infection acquired during passage through the infected birth canal, and 80% are caused by herpes simplex virus type 2 (HSV-2). 6 The imaging diagnosis of neonatal herpes can be challenging due to incomplete myelination with high water contents making it difficult to differentiate between normal and abnormal brain on conventional MRI. Diffusion-weighted MRI is the most valuable sequence in acute stage.…”
Section: Herpes Encephalitismentioning
confidence: 99%
“…In general, HSV-1 transmits significantly more readily to the newborn but more commonly causes an SEM infection and, therefore, is associated with a better prognosis. (11) The incidence of neonatal herpes varies substantially worldwide. Currently, the rate in Seattle, Washington, is about 1 in 3,000 live births.…”
Section: Neonatal Herpesmentioning
confidence: 99%