Difference between mean gestational sac diameter and crown-rump length as a marker of first-trimester pregnancy loss after in vitro fertilization

Kapfhamer, J.D.; Palaniappan, Sruthi; Summers, Karen M.; Kassel, Kristen; Mancuso, Abigail C.; Ryan, Ginny L.; Shah, Divya

doi:10.1016/j.fertnstert.2017.09.031

Cited by 12 publications

(16 citation statements)

References 26 publications

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“…In addition, all IVF-ET patients were treated with ovulation induction. Pregnancy outcomes after the first embryo transfer were calculated, such as multiple ovulations, and the outcomes of the first ovulation in the cycle were studied (Kapfhamer et al, 2018, Chen et al, 2018). Informed consent was signed by all patients as well as their families.…”

Section: Methodsmentioning

confidence: 99%

The relationship between ovarian endometriosis and clinical pregnancy and abortion rate based on logistic regression model

Zeng

2020

Saudi Journal of Biological Sciences

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In order to study the relationship between ovarian endometriosis and clinical pregnancy, explore the correlation between endometriosis (EMT) and abortion rate and its mechanism, and provide a new theoretical basis for clinical diagnosis as well as treatment of endometriosis, in this study, pelvic endometriosis under 40 years old and have in vitro fertilization-embryo transfer (IVF-ET) operation will be selected as subjects of study. SPSS20.0 statistical software is used to analyze the data. When the measurement data between groups are compared, it is necessary to use t-test. It is necessary to use mean ± standard deviation (x¯±s) to expressed the results. When the counting data between groups is compared, it is necessary to use Chi-square test. Finally, the binomial classification logistic regression model is established by stepwise regression method to screen out the significant factors. The results show that the infertility duration of ovarian endometriosis cyst is (3.1 ± 1.9). The infertility years of other pelvic endometriosis are (3.9 ± 2.2). The infertility years of ovarian endometriosis cyst group are shorter than those of other pelvic endometriosis groups. Significant difference cannot be seen in follicle stimulating hormone (FSH) between the two groups of patients, and the basal FSH of other pelvic endometriosis groups is obviously lower in the two groups between the ages of 29 and 40 years. In the ovarian endometriotic cyst group, the significant difference can be seen (P < 0.05). Moreover, in the comparison of ovulation induction, the Gn dosage of fresh-cycle ovarian endometriosis patients is obviously higher than that of patients with ovarian endometriosis during the freezing cycle. The fertilization rate of patients with fresh cycle ovarian endometriosis is higher than that of patients with ovarian endometriosis during the freezing cycle. The two groups of patients with the factor of ovarian endometriosis after fresh embryo transplantation and the factor of fallopian tube are compared, and the abortion rate of the ovarian endometriosis group is lower than that of the fallopian tube group. Therefore, controlling the development of ovarian endometriosis can help to improve the pregnancy rate, reduce the abortion rate and improve the pregnancy outcome of patients with ovarian endometriosis.

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Section: Methodsmentioning

confidence: 99%

The relationship between ovarian endometriosis and clinical pregnancy and abortion rate based on logistic regression model

Zeng

2020

Saudi Journal of Biological Sciences

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“…[18][19][20][21][22][23] However, growth measurements of body composition are not longitudinal in early development. [18][19][20][21][22][23] Numerous percentile charts have been constructed that relate embryo-fetal measurements to GA. 23,24 Recent studies have sought to demonstrate the importance of embryo crown-rump length (CRL) and placental/GS parameters as potential predictors of early pregnancy loss or maternal risk diseases. [24][25][26] However, those studies must be validated with embryonic and GS histologic features seen in embryonic and placental disorders, such as chronic massive intervillositis and gestational trophoblastic disease, among others.…”

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confidence: 99%

“…18,22,23 Some studies investigated efficacy of first-trimester ultrasound parameters such as GS thickness for prediction of maternal risk disorders such as preeclampsia and/or the delivery of small-for-gestational-age neonates; however, there were no specific pathologic aspects reported. 24,25,27,28 Others have documented such parameters as median GS diameter to CRL ratio as better predictors of pregnancy loss than GS diameter and embryo CRL alone. 24,29 Four types of growth disorganization have been established.…”

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confidence: 99%

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Measurements in First-Trimester Abortion Products: A Pathologic Study

Nogueira

Sousa

Braga

et al. 2019

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Related to the advances in prenatal diagnosis and the emergence of medically challenging situations, there has been an increased interest in conducting a pathologic study of first-trimester abortion products. Objective.— To evaluate measurements across a large group of first-trimester spontaneous abortion specimens. Potential goals include a validation of prenatal embryo and gestational-sac measurements as a function of gestational age (GA). Design.— A retrospective case study of first-trimester spontaneous abortions between June 2015 and April 2017 in Centro de Genética Clínica Embryo-Fetal Pathology Laboratory, Porto, Portugal. Considering the inclusion criteria, 585 complete gestational sacs, 182 embryos, and 116 umbilical cords were selected. We recorded the weight of the gestational sacs and embryos and measurements of gestational sacs, umbilical cords, and embryo crown-rump length. Models were computed using regression techniques. Results.— Gestational-sac diameter percentiles 5, 25, 50, 75 and 95 were calculated according to GA, and at each 1-week interval the diameter increased an average of 3 mm. Umbilical cord length percentiles 5, 25, 50, 75 and 95 were calculated according to GA, and at each 1-week interval, the length increased an average of 1.35 mm. Embryo crown-rump length estimated mean ± SD values were GA 6 weeks, 5.3 ± 2.3 mm; GA 7 weeks, 9.4 ± 4.8 mm; GA 8 weeks, 13.7 ± 8.2 mm; GA 9 weeks, 20.8 ± 9.1 mm; GA 10 weeks, 22.6 ± 13.4 mm; GA 11 weeks, 29.4 ± 12.9 mm; and GA 12 weeks, 52 mm. Conclusions.— Pathologic measurements obtained should be compared to expected measurements and correlated with ultrasound findings, clinical information, and microscopic findings. Deviations from expected values could lead to an understanding of early pregnancy loss.

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“…Discrepancies between observed and expected features on ultrasound prior to a loss can be leveraged to estimate gestational age at arrest of development (GAAD) (2,3,11). Investigators in past studies have attempted to identify ultrasound features that predict miscarriage (3,(12)(13)(14)(15) but have not described the gap between GAAD and miscarriage. We aimed to characterize the time that elapses between gestational age at arrest of normal pregnancy development and miscarriage, or the GAAD gap, using early-pregnancy ultrasound examinations from 500 women in Right From the Start (2000-2012), a prospective cohort study, whose pregnancies ended in loss.…”

mentioning

confidence: 99%

Gestational Age at Arrest of Development: An Alternative Approach for Assigning Time at Risk in Studies of Time-Varying Exposures and Miscarriage

Sundermann

Mukherjee

et al. 2018

American Journal of Epidemiology

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The time between arrest of pregnancy development and miscarriage represents a window in which the pregnancy is nonviable and not developing. In effect, the pregnancy loss has already occurred, and additional exposure cannot influence its outcome. However, epidemiologic studies of miscarriage traditionally use gestational age at miscarriage (GAM) to assign time in survival analyses, which overestimates duration of exposure and time at risk. In Right From the Start, a pregnancy cohort study (2000-2012), we characterized the gap between estimated gestational age at arrest of development (GAAD) and miscarriage using transvaginal ultrasound in 500 women recruited from 3 states (North Carolina, Tennessee, and Texas). We compared effect estimates from models using GAAD with GAM to assign time at risk through a simulation study of several exposure patterns with varying effect sizes. The median gap between GAAD and miscarriage was 23 days (interquartile range, 15-32). Use of GAAD decreased the bias and variance of the estimated association for time-varying exposures, whereas half the time using GAM led to estimates that differed from the true effect by more than 20%. Using GAAD to assign time at risk should result in more accurate and consistent characterization of miscarriage risk associated with time-varying exposures.

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Difference between mean gestational sac diameter and crown-rump length as a marker of first-trimester pregnancy loss after in vitro fertilization

Cited by 12 publications

References 26 publications

The relationship between ovarian endometriosis and clinical pregnancy and abortion rate based on logistic regression model

The relationship between ovarian endometriosis and clinical pregnancy and abortion rate based on logistic regression model

Measurements in First-Trimester Abortion Products: A Pathologic Study

Gestational Age at Arrest of Development: An Alternative Approach for Assigning Time at Risk in Studies of Time-Varying Exposures and Miscarriage

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