Difference in clinical features between Japanese and German patients with refractory anemia in myelodysplastic syndromes

Matsuda, Akihisa; Germing, Ulrich; Jinnai, Itsuro; Misumi, Motohiro; Kuendgen, Andrea; Knipp, Sabine; Aivado, Manuel; Iwanaga, Masako; Miyazaki, Yasushi; Tsushima, Hiroyuki; Sakai, Mari; Bessho, Masami; Tomonaga, Masao

doi:10.1182/blood-2005-01-0040

Cited by 99 publications

(72 citation statements)

References 17 publications

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“…12 However, the clinical features of Japanese patients were different from those of German patients as in the previous study. Japanese patients in present study were significantly younger than German patients (median age: Japan, 56 years; Germany, 62 years; P ¼ 0.026).…”

Section: Discussionmentioning

confidence: 48%

“…We held two meetings on BM morphology at the HeinrichHeine University, as reported previously. 12 At the first joint review, we mainly discussed the evaluation of dysplasia and diagnosis using the training slides. After the first joint review, the Japanese and German groups evaluated the detailed morphological analysis separately in each country.…”

Section: Introductionmentioning

confidence: 99%

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Improvement of criteria for refractory cytopenia with multilineage dysplasia according to the WHO classification based on prognostic significance of morphological features in patients with refractory anemia according to the FAB classification

et al. 2007

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In the criteria of refractory cytopenia with multilineage dysplasia (RCMD) according to the WHO (World Health Organization) classification, the frequency threshold concerning dysplasia of each lineage was defined as 10%. To predict overall survival (OS) and leukemia-free survival (LFS) for patients with refractory anemia (RA) according to the French-American-British (FAB) classification, we investigated prognostic factors based on the morphological features of 100 Japanese and 87 German FAB-RA patients, excluding 5q-syndrome. In the univariate analysis of all patients, pseudo-Pelger-Huet anomalies X10% (Pelger þ ), micromegakaryocytes X10% (mMgk þ ), dysgranulopoiesis (dys G) X10% and dysmegakaryopoiesis (dys Mgk) X40% were unfavorable prognostic factors for OS and LFS (OS; Po0.001, LFS; Po0.001). The prognostic effects of the morphological features were similar in both Japanese and German patients. However, dys Mgk X10% was not correlated with OS and LFS. In the multivariate analysis, mMgk þ and dys MgkX40% were adverse prognostic factors for OS for all patients, and dys G X10% and dys MgkX40% were adverse prognostic factors for LFS for all patients. On the basis of the present analysis, we propose the following modified morphological criteria for RCMD. Modified RCMD should be defined as FAB-RA, excluding 5q-syndrome with dys G X10%, dys MgkX40% or mMgk þ .

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Section: Discussionmentioning

confidence: 48%

Section: Introductionmentioning

confidence: 99%

Improvement of criteria for refractory cytopenia with multilineage dysplasia according to the WHO classification based on prognostic significance of morphological features in patients with refractory anemia according to the FAB classification

et al. 2007

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“…The prognostic meaning of del(5q) in MDS also seems to be influenced by genetic background. Data from Japan, 28 China 29 and Korea 30 not only show that del(5q) is less frequent in those populations than in western countries, but also 31 that in the Eastern hemisphere, there is no clear-cut association with good prognosis. Therefore, patients from far east with MDS, especially those with del(5q) have to be regarded as different from the western type patients.…”

Section: Discussionmentioning

confidence: 99%

Survival, prognostic factors and rates of leukemic transformation in 381 untreated patients with MDS and del(5q): A multicenter study

et al. 2012

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Myelodysplastic syndromes (MDS) with del(5q) are considered to have a benign course of the disease. In order to address the issue of the propensity of those patients to progress to acute myeloid leukemia (AML), data on 381 untreated patients with MDS and del(5q) characterized by low or intermediate I International Prognostic Scoring System (IPSS) risk score were collected from nine centers and registries. Median survival of the entire group was 74 months. Transfusion-dependent patients had a median survival of 44 months vs 97 months for transfusion-independent patients (Po0.0001). Transfusion need at diagnosis was the most important patient characteristic for survival. Of the 381 patients, 48 (12.6%) progressed to AML. The cumulative progression rate calculated using the Kaplan --Meier method was 4.9% at 2 years and 17.6% at 5 years. Factors associated with the risk of AML transformation were high-risk World Health Organization adapted Prognostic Scoring System (WPSS) score, marrow blast count 45% and red-cell transfusion dependency at diagnosis. In conclusion, patients with MDS and del(5q) are facing a considerable risk of AML transformation. More detailed cytogenetic and molecular studies may help to identify the patients at risk of progression.

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“…This was lower than presenting age in Western reports of 76 years in United States (Ma et al,2007), 73 years in Dusseldorf, Germany (Neukirchen et al, 2011) (Sole et al, 2005). In Asia MDS has been reported to occur more frequently in younger individuals (Japan (57 years), Korea (53 years) and China (59 years) (Lee et al,1999;Chen B et al, 2005;Matsuda et al, 2005). The reason for the high incidence in younger individuals is still unclear, and the differences in disease features between young and elderly patients with MDS have been not well recognized.…”

Section: Dear Editormentioning

confidence: 99%

Does Indian Myelodysplastic Syndrome have a Biology Different from that in the West ?

Chaubey

Sazawal²,

Mahapatra³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Difference in clinical features between Japanese and German patients with refractory anemia in myelodysplastic syndromes

Cited by 99 publications

References 17 publications

Improvement of criteria for refractory cytopenia with multilineage dysplasia according to the WHO classification based on prognostic significance of morphological features in patients with refractory anemia according to the FAB classification

Improvement of criteria for refractory cytopenia with multilineage dysplasia according to the WHO classification based on prognostic significance of morphological features in patients with refractory anemia according to the FAB classification

Survival, prognostic factors and rates of leukemic transformation in 381 untreated patients with MDS and del(5q): A multicenter study

Does Indian Myelodysplastic Syndrome have a Biology Different from that in the West ?

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