Difference in Insulin Usage Patterns with Pubertal Development in Children with Type 1 Diabetes During Transition from Multiple Daily Injections to Continuous Subcutaneous Insulin Infusion (CSII) and Through the CSII Treatment

Abstract

Age-related differences exist in insulin usage patterns of pediatric patients on pump treatment. A greater knowledge of these variations may help to obtain optimum conditions in the CSII treatment in pediatric patients.

Optimum bolus wizard settings in insulin pumps in children with Type 1 diabetes

“…Several studies have shown the importance of individualizing insulin treatment, and there is therefore a need for individual pump settings and calculation factors in order to achieve optimum control [4,10,[15][16][17][18]. Improved metabolic control is linked to the use of the bolus wizard [2,9], but clinical guidelines for initial and ongoing settings of the bolus wizard are scarce [10,11,14].…”

Predictors of changing insulin dose requirements and glycaemic control in children, adolescents and young adults with Type 1 diabetes

“…Other reports have shown that girls have higher insulin requirements than boys during adolescence as a result of lower insulin sensitivity in girls, which is probably related to increasing adiposity and decreasing physical activity during puberty [16]. Additionally, insulin pump therapy has been associated with lower insulin requirements [16–18]; however, the impact of weight, sex and regimen on insulin requirements, as well as trajectories of insulin dose and HbA 1c according to age requires further study.…”

Polymorphic Basal Rates of Continuous Subcutaneous Insulin Infusion among Taiwanese Children with Type 1 Diabetes

“…The adjusted proportion of basal to total daily demand was less than 40%. This is a relatively high bolus insulin proportion compared to the 50% reported in other studies [ 16 – 22 ]. Rice-based meal contents and low fatty food in the typical Taiwanese diet may be a possible explanation of this discrepancy [ 23 ].…”