Difference in Relapse Rates of Duodenal Ulcer After Healing With Cimetidine or Tripotassium Dicitrato Bismuthate

Twice daily tripotassium dicitrato bismuthate in the treatment of duodenal ulceration

“…The rate of healing observed at 4 weeks (72%) and 8 weeks (92%) in the group given treatment twice daily is comparable with that previously reported for TDB (66% at 4 weeks and 89% at 8 weeks) and cimetidine (60% at 4 weeks and 85% at 8 weeks) (Martin et al, 1981). No adverse effects peculiar to the twice daily TDB regime were encountered.…”

“…Tripotassium dicitrato bismuthate (TDB) in both liquid (Martin et al, 1981;Shreeve et al, 1983) and tablet form (Vantruppen et al, 1980;Moshal et al, 1981) has been shown to heal duodenal ulceration as effectively as cimetidine. However, while the trend for some other ulcer healing drugs, particularly the H2 antagonists, has been to move to a twice or single daily dose it is recommended by the manufacturers of TDB (Gist Brocades) that the drug be given four times daily.…”

Effect of treatment of Helicobacter pylori on the prevention of gastroduodenal ulcers in patients receiving long‐term NSAIDs: a double‐blind, placebo‐controlled trial

“…The 1-year relapse rate of ulcers treated with bismuth-containing compounds is lower than that for ulcers treated with other acid suppressive therapy. 19,20 This may also account for the difference in the rates of ulcer development in previous studies. One major drawback of this study was that the observed incidence of ulcers was much lower than that used in the power calculation for sample size.…”

Immunoblot fingerprinting of Campylobacter pylori

“…In favour of an active role is the finding that deliberate ingestion of the organism results in active gastritis in man (Marshall et al, 1985;Morris and Nicholson, 1986) and in gnotobiotic piglets (Lambert et al, 1987). C. pylori is sensitive to bismuth which has been used to treat gastritis (McNulty et al, 1986) and duodenal ulcers (Martin et al, 1981). Relapse following the treatment of duodenal ulceration has been linked to the re-isolation of C. pylori from biopsy material (Coghlan et al, 1987).…”