Difference in the Changings of Blood Coagulation Fibrinolysis Markers Before
and After Spinal Surgery in Adolescent and Elderly Patients

Watanabe, Hideaki; Inoue, Hirokazu; Sugawara, Ryo; Hayasaka, Shinya; Kikkawa, Ichiro; Takeshita, Katsushi

doi:10.17554/j.issn.2311-5106.2017.04.222

Cited by 1 publication

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Literature has shown that FM can be used to detect hypercoagulable states during the surgical period, for example, increased FM on POD1 was associated with DVT development. 42,43 Similar to VTE, these studies have also shown using FM and DD together is more accurate for diagnosing early post-op DVTs. More research is needed comparing FM levels prior to, during and after surgery, as well as how DVT prophylaxis during the surgical period (whether anti-coagulants or compression stockings) could affect FM.…”

Section: Discussionmentioning

confidence: 86%

The Clinical Significance of Fibrin Monomers

et al. 2018

View full text Add to dashboard Cite

Introduction Fibrin monomer (FM) concentrations reflect pro-thrombin activity and have the potential to predict thrombotic events relatively earlier than other haemostatic markers. Most often, FM are compared with D-dimer (DD) as increased DD have been documented in disseminated intravascular coagulation (DIC), deep vein thrombosis (DVT) and pulmonary embolism. Although DD have a high sensitivity and negative predictive value, their specificity is much lower depending on the assay chosen, clinical pre-test probability and patient condition. There are limited reports investigating the utility of FM in hyper-coagulable patients. Methods We performed a literature search of FM concentrations in hyper-coagulable patients including those with DIC, acute ischaemic stroke, atrial fibrillation, acute myocardial infarction, venous thromboembolism (VTE) and cancer, as well as those who are pregnant or undergoing surgery. Results FM were increased in patients with DIC and those with malignancy. In contrast, detection of VTE or post-operative DVT development is likely enhanced using both FM and DD concentrations. Similarly, measuring FM concentrations with other biomarker levels may be more beneficial in patients suffering an acute myocardial infarction or acute ischaemic stroke. Lastly, FM concentrations vary substantially throughout pregnancy with no definitive role of FM as of yet. Conclusion Utilizing FM concentrations to assess hyper-coagulable patients seems promising; however, there are limitations including variations in FM cut-off values, the effect of patient medications and the timing of FM measurement relative to an acute event. Thus, further investigation is required before a true advantage for FM as a haemostatic marker can be established.

show abstract

Section: Discussionmentioning

confidence: 86%