Difference in the regulation of biological rhythm symptoms of Major depressive disorder between escitalopram and mirtazapine

Huang, Haijing; Wang, Fan; Chen, Yiming; Kong, Shuqi; Huang, Qinte; Lyu, Dongbin; Yang, Weichieh; Wei, Zheyi; Qian, Nuoshi; Zhang, Mengke; Wu, Chenglin; Zhao, Jie; Cao, Lan; Wu, Zhiguo; Peng, Daihui; Fang, Yiru; Wu, Hong

doi:10.1016/j.jad.2021.09.050

Cited by 5 publications

(3 citation statements)

References 29 publications

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“…However, there was no significant change in the contralateral paws ( Supplementary Figure 1A ). We also found that the weight of rats in the SNI group was significantly less than that in the sham group at 21 and 28 days after surgery ( Figure 1C ), which is in line with the results of clinical studies that weight loss in patients with anxiety and depression ( Huang H. et al, 2021 ).…”

Section: Resultssupporting

confidence: 89%

The cAMP Response Element- Binding Protein/Brain-Derived Neurotrophic Factor Pathway in Anterior Cingulate Cortex Regulates Neuropathic Pain and Anxiodepression Like Behaviors in Rats

Wen

et al. 2022

Front. Mol. Neurosci.

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Neuropathic pain is often accompanied by anxiety and depression-like manifestations. Many studies have shown that alterations in synaptic plasticity in the anterior cingulate cortex (ACC) play a critical role, but the specific underlying mechanisms remain unclear. Previously, we showed that cAMP response element-binding protein (CREB) in the dorsal root ganglion (DRG) acts as a transcription factor contributing to neuropathic pain development. At the same time, brain-derived neurotrophic factor (BDNF), as important targets of CREB, is intricate in neuronal growth, differentiation, as well as the establishment of synaptic plasticity. Here, we found that peripheral nerve injury activated the spinal cord and ACC, and silencing the ACC resulted in significant relief of pain sensitivity, anxiety, and depression in SNI rats. In parallel, the CREB/BDNF pathway was activated in the spinal cord and ACC. Central specific knockdown and peripheral non-specific inhibition of CREB reversed pain sensitivity and anxiodepression induced by peripheral nerve injury. Consequently, we identified cingulate CREB/BDNF as an assuring therapeutic method for treating neuropathic pain as well as related anxiodepression.

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Section: Resultssupporting

confidence: 89%

The cAMP Response Element- Binding Protein/Brain-Derived Neurotrophic Factor Pathway in Anterior Cingulate Cortex Regulates Neuropathic Pain and Anxiodepression Like Behaviors in Rats

Wen

et al. 2022

Front. Mol. Neurosci.

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“…Ensrud et al reported that escitalopram was effective for insomnia in a RCT of 205 peri-and post-menopausal women with HFs [82]. Mirtazapine is also known to be useful in cases of not only insomnia but also depression, which has a sleep-inducing effect and increased slow-wave sleep effect, along with side effects such as appetite, weight gain, and dry mouth [83]. However, there are limited studies on the direct effects of these antidepressants on insomnia; therefore, using antidepressants to treat sleep disruption for women without depression should not be recommended [70].…”

Section: Antidepressantsmentioning

confidence: 99%

Insomnia in Postmenopausal Women: How to Approach and Treat It?

Jeon

2024

JCM

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Insomnia is one of the major complaints of menopausal women with advancing age and may be complexly related to a variety of causes. However, there is still a lack of standards on the general approach and treatment for insomnia in menopausal women. The aim of this review is to summarize recent pathogenic theories of sleep disturbance in the menopausal period and discuss the approach and management of insomnia in postmenopausal women. Sleep disturbances in menopausal women may be associated with physical and psychiatric factors and other comorbid diseases. Careful history taking and multidisciplinary physical and psychosocial evaluation are necessary and, in particular, comorbidities related to sleep disorders, such as obstructive sleep apnea, must be taken into consideration. A unique aspect of insomnia in postmenopausal women is that menopausal symptoms due to hormonal decline can be closely related to sleep disturbances. Therefore, menopausal hormone therapy (MHT) should be considered as the treatment of choice among pharmacological treatments following cognitive behavioral therapy, which is suggested as the first-line treatment in the general population insomnia treatment guidelines. Additionally, melatonin and 5HT-based drugs, which have fewer side effects, along with MHT should be preferentially recommended in menopausal women.

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“…Considering the most favorable balance between benefits, acceptability, acquisition cost and mechanism-based targeting of receptor for antidepressant, we chose escitalopram and mirtazapine as the antidepressant agents in AGT. Although no advantage of treatment outcome was shown in head-to-head studies between the two antidepressants [ 15 ], mirtazapine was more effective in improving weight, poor appetite and biological rhythm symptoms of MDD [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Program of algorithm for pharmacological treatment of major depressive disorder in China: Benefits or not?

Zhu,

Wang,

Wang

et al. 2023

Heliyon

Self Cite

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Difference in the regulation of biological rhythm symptoms of Major depressive disorder between escitalopram and mirtazapine

Cited by 5 publications

References 29 publications

The cAMP Response Element- Binding Protein/Brain-Derived Neurotrophic Factor Pathway in Anterior Cingulate Cortex Regulates Neuropathic Pain and Anxiodepression Like Behaviors in Rats

The cAMP Response Element- Binding Protein/Brain-Derived Neurotrophic Factor Pathway in Anterior Cingulate Cortex Regulates Neuropathic Pain and Anxiodepression Like Behaviors in Rats

Insomnia in Postmenopausal Women: How to Approach and Treat It?

Program of algorithm for pharmacological treatment of major depressive disorder in China: Benefits or not?

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