Differences and Similarities in Neuropathy in Type 1 and 2 Diabetes: A Systematic Review

Sempere-Bigorra, Mar; Julián-Rochina, Iván; Cauli, Omar

doi:10.3390/jpm11030230

Cited by 26 publications

(17 citation statements)

References 87 publications

(185 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Diabetes, as a disease characterized by hyperglycemia, is related to diverse complications, including cardiovascular disease, stroke, kidney failure, neuropathy, retinopathy, and amputation (Al-Sofiani et al, 2019;Lau et al, 2019;Buades et al, 2021;Sempere-Bigorra et al, 2021;Milluzzo et al, 2021;O'neill et al, 2017). It is reported that diabetes can be divided into three types: Gestational diabetes, type 1 diabetes (T1D), and type 2 diabetes (T2D) (Xiang et al, 2018).…”

Section: Diabetic Imagingmentioning

confidence: 99%

H2S-based fluorescent imaging for pathophysiological processes

Jia

Zhang²,

Hou³

et al. 2023

Front. Chem.

View full text Add to dashboard Cite

Hydrogen sulfide (H2S), as an important endogenous signaling molecule, plays a vital role in many physiological processes. The abnormal behaviors of hydrogen sulfide in organisms may lead to various pathophysiological processes. Monitoring the changes in hydrogen sulfide is helpful for pre-warning and treating these pathophysiological processes. Fluorescence imaging techniques can be used to observe changes in the concentration of analytes in organisms in real-time. Therefore, employing fluorescent probes imaging to investigate the behaviors of hydrogen sulfide in pathophysiological processes is vital. This paper reviews the design strategy and sensing mechanisms of hydrogen sulfide-based fluorescent probes, focusing on imaging applications in various pathophysiological processes, including neurodegenerative diseases, inflammation, apoptosis, oxidative stress, organ injury, and diabetes. This review not only demonstrates the specific value of hydrogen sulfide fluorescent probes in preclinical studies but also illuminates the potential application in clinical diagnostics.

show abstract

Section: Diabetic Imagingmentioning

confidence: 99%

H2S-based fluorescent imaging for pathophysiological processes

Jia

Zhang²,

Hou³

et al. 2023

Front. Chem.

View full text Add to dashboard Cite

show abstract

“…There is also a link between the levels of ICAM-1 and diabetic neuropathy [22]. So, both CRP and soluble adhesion molecules can be considered as attractive early predictors of diabetic complications and therapeutic targets for diabetic patients [23].…”

Section: Similarly With Regards To Cell Adhesion Molecules a Linear Association Was Reported Between Elevations Of Icam-1 And Diabetic Rementioning

confidence: 99%

Amelioration of Endothelial Dysfunction and Inflammation in Type 2 Diabetic Patients after Black Seed Oil Supplementation.

Elgarf

Aboromia

Sabri

et al. 2021

Archives of Pharmaceutical Sciences Ain Shams University

View full text Add to dashboard Cite

Endothelial dysfunction is a crucial contributor to the development of vascular problems. Nigella sativa L. seed oil which is commonly known as black seed oil is an antioxidant, anti-inflammatory, and hypoglycemic agent that can be considered as an attractive candidate for improving endothelial dysfunction. Our objective is to evaluate the impact of Nigella sativa seed oil on intercellular adhesion molecule-1 (ICAM-1) and high sensitivity c-reactive protein (hsCRP), as well as the quality of life of type 2 diabetic patients. A prospective, randomized, placebocontrolled, double-blinded study was conducted and registered in ClinicalTrials.gov (NCT03959306). Patients were randomly given either 1800 mg/day of black seed oil or placebo capsules for 12 weeks. Full clinical history, biochemical glycemic indices, lipid profile, kidney and liver functions, hsCRP, ICAM-1, as well as diabetes-39 questionnaire were assessed at baseline and end of the study. After 12 weeks, the levels of hemoglobin A1C, total cholesterol, triglycerides, hsCRP, and ICAM-1, as well as diabetes control domain scores decreased significantly in the intervention group compared to the control group. In conclusion, the administration of black seed oil over 12 weeks showed superior efficacy over standard treatment alone in the management of type 2 diabetes mellitus and can be considered as a therapeutic option for improving endothelial dysfunction.

show abstract

“…Diabetes mellitus (DM) describes a state of chronic hyperglycemia that affects more than 460 million individuals worldwide [ 1 ]. The number of patients with DM has been projected to rise to 700 million worldwide by 2045 [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Obstetric Neuropathy in Diabetic Patients: The “Double Hit Hypothesis”

Nguyen

Zaferanieh

Black

et al. 2023

IJMS

View full text Add to dashboard Cite

The two-hit model has been proposed to explain the effects of diabetes on mothers who are already in a putative subclinical damaged state and then undergo neuronal damage during the delivery process. However, the anatomical and pathophysiological mechanisms are not well understood. Our overarching hypothesis in this review paper is that pregnant women who are diabetic have a damaged peripheral nervous system, constituting the “first hit” hypothesis. The delivery process itself—the “second hit”—can produce neurological damage to the mother. Women with diabetes mellitus (DM) are at risk for neurological damage during both hits, but the cumulative effects of both “hits” pose a greater risk of neurological damage and pathophysiological changes during delivery. In our analysis, we introduce the different steps of our concept paper. Subsequently, we describe each of the topics. First, we outline the mechanisms by which diabetes acts as a detrimental variable in neuropathy by focusing on the most common form of diabetic neuropathy, diabetic distal symmetrical polyneuropathy, also known as distal sensorimotor neuropathy. The possible role of macrosomia in causing diabetic neuropathy and obstetric neurological injury is discussed. Second, we describe how vaginal delivery can cause various obstetrical neurological syndromes and pathophysiological changes. Third, we highlight the risk of obstetric neuropathy and discuss anatomical sites at which lesions may occur, including lesions during delivery. Fourth, we characterize the pathophysiological pathways involved in the causation of diabetic neuropathy. Finally, we highlight diabetic damage to sensory vs. motor nerves, including how hyperglycemia causes different types of damage depending on the location of nerve cell bodies.

show abstract

Differences and Similarities in Neuropathy in Type 1 and 2 Diabetes: A Systematic Review

Cited by 26 publications

References 87 publications

H2S-based fluorescent imaging for pathophysiological processes

H2S-based fluorescent imaging for pathophysiological processes

Amelioration of Endothelial Dysfunction and Inflammation in Type 2 Diabetic Patients after Black Seed Oil Supplementation.

Obstetric Neuropathy in Diabetic Patients: The “Double Hit Hypothesis”

Contact Info

Product

Resources

About