Differences between finger and toe Meissner corpuscles: Searching for the optimal place to analyze meissner corpuscles in cutaneous biopsy

Cuendias, Patricia; Rio, Rebeca del; García‐Suárez, Olivia; Cobo, Ramón; Aragona, Marialuisa; Feito, Jorge; Martín‐Biedma, Benjamín; Vega, J.A.; García‐Mesa, Yolanda

doi:10.1016/j.tria.2023.100234

Cited by 1 publication

(1 citation statement)

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“…One important limitation of the present study is the age range of participants from 26 to 55 years. For older individuals (>65 years), an increased keratinization and a breakdown of both the dermal–epidermal junction and the sensory corpuscles, such as MCs, has been reported [ 16 , 27 ]. Future investigations will address the morphology of the protrusions in individuals of high age.…”

Section: Discussionmentioning

confidence: 99%

Revealing the Meissner Corpuscles in Human Glabrous Skin Using In Vivo Non-Invasive Imaging Techniques

Infante

Bennewitz

Klein

et al. 2023

IJMS

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The presence of mechanoreceptors in glabrous skin allows humans to discriminate textures by touch. The amount and distribution of these receptors defines our tactile sensitivity and can be affected by diseases such as diabetes, HIV-related pathologies, and hereditary neuropathies. The quantification of mechanoreceptors as clinical markers by biopsy is an invasive method of diagnosis. We report the localization and quantification of Meissner corpuscles in glabrous skin using in vivo, non-invasive optical microscopy techniques. Our approach is supported by the discovery of epidermal protrusions which are co-localized with Meissner corpuscles. Index fingers, small fingers, and tenar palm regions of ten participants were imaged by optical coherence tomography (OCT) and laser scan microscopy (LSM) to determine the thickness of the stratum corneum and epidermis and to count the Meissner corpuscles. We discovered that regions containing Meissner corpuscles could be easily identified by LSM with an enhanced optical reflectance above the corpuscles, caused by a protrusion of the strongly reflecting epidermis into the stratum corneum with its weak reflectance. We suggest that this local morphology above Meissner corpuscles has a function in tactile perception.

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Section: Discussionmentioning

confidence: 99%