Differences between inflamed and non inflamed appendices diagnosed as acute appendicitis

Nascimento, Pedro; Brandt, Carlos Teixeira; Petroianu, Andy

doi:10.1016/j.amsu.2021.01.044

Cited by 4 publications

(7 citation statements)

References 48 publications

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“…In multivariable analysis, appendicitis was associated with abdominal pain and lymphopenia but not with MIS-C; notably, 40.0% of the diagnoses were not histologically confirmed. This high percentage of histologically proven negative cases in children with COVID-19 contrasts with previous evidence reporting less than 20% of unconfirmed diagnoses in children undergoing appendectomy before the pandemic era …”

Section: Discussioncontrasting

confidence: 91%

“…This high percentage of histologically proven negative cases in children with COVID-19 contrasts with previous evidence reporting less than 20% of unconfirmed diagnoses in children undergoing appendectomy before the pandemic era. 22,23 Consistent with previous evidence, 24 in some of the children in this report, SARS-CoV-2 might have triggered appendicitis with a typical clinical and histologic feature and an expected complication rate of 10% to 20%. However, children with MIS-C showing appendicitislike symptoms had a low rate of complications and histologic findings of serositis and perivisceritis in the absence of intraluminal obstruction.…”

Section: Jama Network Open | Pediatricssupporting

confidence: 90%

Section: Discussionsupporting

confidence: 66%

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Factors Associated With Severe Gastrointestinal Diagnoses in Children With SARS-CoV-2 Infection or Multisystem Inflammatory Syndrome

et al. 2021

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Section: Discussioncontrasting

confidence: 91%

Section: Jama Network Open | Pediatricssupporting

confidence: 90%

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Factors Associated With Severe Gastrointestinal Diagnoses in Children With SARS-CoV-2 Infection or Multisystem Inflammatory Syndrome

et al. 2021

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“…The most prevalent causes of juvenile appendicitis are fecalith blockage [14] and bacterial hematological spread [15]. Obstruction causes dilatation, which promotes bacterial growth in the appendix lumen, resulting in ischemia and necrosis of the appendix wall.…”

Section: Discussionmentioning

confidence: 99%

Mast Cell Essential Roles: Will it be a Novel Tool for Differentiating the Severity of Pediatric Appendicitis?

Poerwosusanta

Gunadi

Gunawan

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: Appendicitis is an undesirable diagnosis, and the Alvarado score (AS) alone is insufficient in recognizing it. Many novel laboratory indicators, such as leukocytes and mast cells, differentiate. AIM: Our objective was to demonstrate that mast cells had a greater influence on appendicitis severity than the AS, neutrophils, and platelets. MATERIALS AND METHODS: An observational research in which 35 individuals with acute appendicitis at our institutions were identified for the appendix grade and allocated to one of two groups: Complicated or non-complicated. The AS and white blood cell count were calculated using the neutrophil-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), thrombocyte-to-neutrophil ratio (TNR), and total leukocyte. Mast cell count and granulation are evaluated using pathological anatomy. RESULTS: TLR could not distinguish between severe appendicitis and others, but some showed potential. NLR, TNR, total leukocyte, ASs, mast cell count, and degranulation demonstrated good sensitivity-specificity values. CONCLUSIONS: Mast cells have the potential to become a promising approach for predicting complicated pediatric appendicitis.

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“…In daily surgical and emergency settings, the surgeons may not exclude the malignancy, and a radical resection may be necessary. [12][13][14][15] A recent questionnaire study performed by Ahmad I et al 9 showed no agreed consensus on the management of appendicecal mass in the Mid-Trent region of England. In the present study, except for a young patient, all of the patients underwent a right hemicolectomy since this is a reasonable procedure in our clinic if the surgeon could not exclude the malignancy.…”

Section: Discussionmentioning

confidence: 99%

Emergency Right Hemicolectomy for Pericecal Masses Mimicking Acute Appendicitis: Surgeon’s Fearful Dilemma

Turan¹,

Kılavuz²,

İrkörücü³

2022

Eur J Ther

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Objective: Unexpected conglomerated pericecal masses of uncertain etiology encountered in emergency surgery may be indistinguishable, and proper operative strategic management of these cases is a dilemma for digestive system surgeons. Starting from this point, we decided to analyze the patients in whom a right hemicolectomy was performed for the pericecal mass during an appendectomy in our regional hospital. Methods: Over 8 years between March 2011 and May 2019, 4783 patients who lived in the eastern Mediterranean area underwent emergency surgery for clinical diagnosis of acute appendicitis, and a right hemicolectomy for inflammatory pericecal mass was performed in 44 patients included in this study. Patient records were reviewed for sex, age, preoperative symptoms, preoperative imaging, operation findings, preoperative Complete Blood Count (CBC) and biochemical findings, pathology reports, length of hospital stay, mortality, and any complications encountered. Results:The histopathological examination revealed that 5 of 44 (11.4%) patients had malignancy while 27 of 44 patients (88.6%) had benign pathologies. All of the malignancies were adenocarcinoma. According to age, there was a statistically significant difference between patients with and without malignancy (P < .05). Conclusion:The pericecal mass in emergency surgery is still a diagnostic and therapeutic dilemma. Hidden appendiceal neoplasm in acute appendicitis is rare but its incidence is higher in patients presenting appendiceal inflammatory mass. On the other hand, most unexpected inflammatory pericecal masses are due to benign pathologies. The choice of the surgical procedure depends on the surgeon's and institute's experience.

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Differences between inflamed and non inflamed appendices diagnosed as acute appendicitis

Cited by 4 publications

References 48 publications

Factors Associated With Severe Gastrointestinal Diagnoses in Children With SARS-CoV-2 Infection or Multisystem Inflammatory Syndrome

Factors Associated With Severe Gastrointestinal Diagnoses in Children With SARS-CoV-2 Infection or Multisystem Inflammatory Syndrome

Mast Cell Essential Roles: Will it be a Novel Tool for Differentiating the Severity of Pediatric Appendicitis?

Emergency Right Hemicolectomy for Pericecal Masses Mimicking Acute Appendicitis: Surgeon’s Fearful Dilemma

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