Differences Between Lactase Deficient and Nonlactase Deficient Women with Spinal Osteoporosis

Vigorita, Vincent J.; Lane, Joseph M.; Suda, Marilyn K.; Nelkin, Mindy

doi:10.1097/00003086-198702000-00036

Cited by 8 publications

(7 citation statements)

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“…In some of these studies (Newcomer et al 1 9 7 8~;Horowitz et al 1987;Vigorita et al 1987) this relationship was confirmed by the finding of a higher prevalence of lactose malabsorbers in osteoporotic than in non-osteoporotic women. In all previous studies prevalence of lactose malabsorbers range from 26 YO (Newcomer et al 1978 a) to 65 YO (Vigorita et al 1987) in osteoporotic women and from 0 % (Birge et al 1967) to 20% (Harma & Alhava, 1988) in nonosteoporotic women. Compared with these values our prevalence value was much higher both in osteoporotic (76 %) and non-osteoporotic women (64 YO).…”

Section: Discussionmentioning

confidence: 85%

“…This result confirms previous findings of a high prevalence of primary late-onset lactase deficiency in the Italian population (Burgio et al 1984;Bozzani et al 1986), and could explain the absence of a statistically significant difference between osteoporotic and non-osteoporotic women. In some of the previous studies (Newcomer et al 1 9 7 8~;Horowitz et al 1987;Vigorita et al 1987) the lower Ca intake found in lactose malabsorbers than in absorbers was attributed to the avoidance of milk and milk products due to lactose malabsorption. Unlike these studies (Newcomer et al 1978a;Horowitz et al 1987;Vigorita et aE.…”

Section: Discussionmentioning

confidence: 89%

“…Since lactose malabsorption might cause a marked reduction in milk and milk-product consumption (Bayless,198l), which together provide most of the Ca in the diet (Birge et al 1967;Newcomer et al 1978a), the relationship between lactose malabsorption and postmenopausal osteoporosis has been extensively studied (Birge et al 1967;Alhava et al 1977;Newcomer et al 1 9 7 8~;Finkenstedt et al 1986;Horowitz et al 1987;Jodry et al 1987;Vigorita et al 1987;Harma & Alhava, 1988;Slemenda et al 1991). In some of these studies (Newcomer et al 1 9 7 8~;Horowitz et al 1987;Vigorita et al 1987) this relationship was confirmed by the finding of a higher prevalence of lactose malabsorbers in osteoporotic than in non-osteoporotic women. In all previous studies prevalence of lactose malabsorbers range from 26 YO (Newcomer et al 1978 a) to 65 YO (Vigorita et al 1987) in osteoporotic women and from 0 % (Birge et al 1967) to 20% (Harma & Alhava, 1988) in nonosteoporotic women.…”

Section: Discussionmentioning

confidence: 99%

“…Since these foodstuffs provide about two-thirds of the dietary requirement of Ca (Birge et al 1967;Newcomer et al 1978 a) lactose malabsorption has been suggested as a predisposing factor to osteoporosis (Birge et al 1967;Newcomer et al 1978a;Finkenstedt et al 1986;Horowitz ct al. 1987;Vigorita et al 1987).. However, other studies have failed to show a clear relationship between these two conditions (Alhava et al 1987;Jodry et al 1987;Harma & Alhava, 1988;Slemenda et al 1991).…”

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confidence: 95%

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Lactose intolerance and bone mass in postmenopausal Italian women

et al. 1995

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Previous studies on the role of lactose malabsorption in the pathogenesis of postmenopausal osteoporosis have yielded conflicting results and further information is needed. To date, all studies have been carried out on populations with a low prevalence of lactose malabsorption and the lactose intestinal absorptive capacity was tested using a non-physiological dose of lactose. In fifty-eight Italian postmenopausal women (mean age 57 (SD 7) years), bone mineral density (BMD) at lumbar spine, H, breath response after ingestion of 20 g lactose, intensity of symptoms of intolerance after a lactose load and daily Ca intake were evaluated. No differences were found between women with or without a positive H, breath test with regard to BMD (-1.2 (SD 0.9) v. -0.9 (SD 0.8)) and Ca intake (509 (SD 266) v. 511 (SD 313) mg/d). On the contrary, both BMD and Ca intake were significantly lower in women with lactose malabsorption and symptoms of intolerance (-1.5 (SD 0.7) and 378 (SD 220) mg/d) than in those with malabsorption without symptoms (-0.9 (SD 0.9) and 624 (SD 254) mg/d). Moreover, in lactose malabsorbers Ca intake was correlated inversely with symptom score (rs -0.31, P < 005) and positively with BMD (r, 0.42, P < 0.005). Our results show that in Italian postmenopausal women Ca intake and BMD are not influenced directly by lactose malabsorption; the appearance of symptoms of intolerance seems to influence BMD unfavourably through a reduced Ca intake.Calcium: 4 breath test: Lactose: Osteoporosis: Postmenopausal women

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 95%

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Lactose intolerance and bone mass in postmenopausal Italian women

et al. 1995

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“…Others have failed to confirm this relationship [10][11][12]. Furthermore, lactose intolerance resulted in higher fracture rate on weight-bearing bones [13] and altered mineralization with increased both osteoid volume and seam widths [14].…”

Section: Introductionmentioning

confidence: 99%

LCT 13910 C/T polymorphism, serum calcium, and bone mineral density in postmenopausal women

et al. 2008

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No evidence for an effect of lactase deficiency on bone mass in pre- or postmenopausal women

Slemenda

Christian

Hui

et al. 1991

Journal of Bone and Mineral Research

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The potential role for lactase deficiency in the development of low bone mass was examined in 342 adult female twins. Diminished lactase activity, defined as greater than 20 ppm increase in expired hydrogen at 2 or 2.5 h after an oral lactose load, was examined: (1) by comparing bone mass between members of twin pairs discordant for lactase activity; (2) by examining the linear association between bone mass and total expired hydrogen gas; and (3) by comparing all lactase-deficient individuals to those with persistent lactase activity. Among members of discordant (primarily DZ) pairs, the lactase-deficient member had greater bone mass 54% of the time. The correlations between the increase in expired hydrogen and bone mass at various sites were between -0.02 (femoral neck) and 0.11 (midshaft radius), suggesting no association between these variables. Finally, all lactase-deficient subjects were compared with those with normal lactase activity, regardless of twin status, and at each skeletal site the differences in bone mass were 1% or less. Thus, all primary hypotheses were not supported by these data; that is, in this large sample we could find no evidence of a detrimental effect of lactase deficiency on adult bone mass. However, baseline expired hydrogen was consistently and positively associated with bone mass at all sites, independently of age, suggesting the possibility that some aspect of intestinal function related to the activity of bacterial anaerobes may be positively associated with bone mass.

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Differences Between Lactase Deficient and Nonlactase Deficient Women with Spinal Osteoporosis

Cited by 8 publications

References 0 publications

Lactose intolerance and bone mass in postmenopausal Italian women

Lactose intolerance and bone mass in postmenopausal Italian women

LCT 13910 C/T polymorphism, serum calcium, and bone mineral density in postmenopausal women

No evidence for an effect of lactase deficiency on bone mass in pre- or postmenopausal women

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