Differences between peritoneal and pleural mesothelioma in Lombardy, Italy

Mensi, Carolina; Mendola, Marco; Dallari, Barbara; Sokooti, Maryam; Tabibi, Ramin; Riboldi, Luciano; Consonni, Dario

doi:10.1016/j.canep.2017.10.003

Cited by 11 publications

(6 citation statements)

References 17 publications

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“…A high impact of asbestos exposure on MM occurrence has been shown in Lombardy 17–19. Comparing peritoneal and pleural mesothelioma characteristics, we recently found similar frequencies of asbestos exposure but higher proportions of asbestosis and exposure in the asbestos-cement industry among PeM cases 20…”

Section: Introductionsupporting

confidence: 54%

Peritoneal mesothelioma and asbestos exposure: a population-based case–control study in Lombardy, Italy

et al. 2019

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ObjectivesAsbestos is the main risk factor for peritoneal mesothelioma (PeM). However, due to its rarity, PeM has rarely been investigated in community-based studies. We examined the association between asbestos exposure and PeM risk in a general population in Lombardy, Italy.MethodsFrom the regional mesothelioma registry, we selected PeM cases diagnosed in 2000–2015. Population controls (matched by area, gender and age) came from two case–control studies in Lombardy on lung cancer (2002–2004) and pleural mesothelioma (2014). Assessment of exposure to asbestos was performed through a quantitative job-exposure matrix (SYN-JEM) and expert evaluation based on a standardised questionnaire. We calculated period-specific and gender-specific OR and 90% CI using conditional logistic regression adjusted for age, province of residence and education.ResultsWe selected 68 cases and 2116 controls (2000–2007) and 159 cases and 205 controls (2008–2015). The ORs for ever asbestos exposure (expert-based, 2008–2015 only) were 5.78 (90% CI 3.03 to 11.0) in men and 8.00 (2.56 to 25.0) in women; the ORs for definite occupational exposure were 12.3 (5.62 to 26.7) in men and 14.3 (3.16 to 65.0) in women. The ORs for ever versus never occupational asbestos exposure based on SYN-JEM (both periods) were 2.05 (90% CI 1.39 to 3.01) in men and 1.62 (0.79 to 3.27) in women. In men, clear positive associations were found for duration, cumulative exposure (OR 1.33 (1.19 to 1.48) per fibres/mL-years) and latency.ConclusionsUsing two different methods of exposure assessment we provided evidence of a clear association between asbestos exposure and PeM risk in the general population.

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Section: Introductionsupporting

confidence: 54%

Peritoneal mesothelioma and asbestos exposure: a population-based case–control study in Lombardy, Italy

et al. 2019

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“…3 a,b). Therefore, RhoA staining is highly stable and useful for the differential diagnosis of epithelioid MM 26 , 27 .…”

Section: Discussionmentioning

confidence: 99%

RhoA and vigilin are candidates for immunohistochemical markers for epithelioid malignant mesothelioma

Hiratsuka

Yamamoto

Yoshizawa

et al. 2022

Sci Rep

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Diagnostic markers of malignant mesothelioma (MM) have been extensively investigated. Immunohistochemistry (IHC) markers, such as calretinin, have been used for pathologic diagnosis. However, more diagnostic markers are required to improve the specificity and sensitivity of pathologic diagnosis. This study proposed two proteins as diagnostic markers for epithelioid MM. One is RhoA, an MM mutation-susceptible locus-derived protein, and another is vigilin, a lung small cell carcinoma marker. IHC was performed using 93 MM (epithelioid, 71 cases; sarcomatoid, 13 cases; and biphasic, 9 cases), 64 lung adenocarcinoma (LAC), 60 lung squamous cell carcinoma (LSC), and 14 normal mesothelial (NM) tissues. The majority of epithelioid MM cases were positive for both RhoA and vigilin, whereas both IHCs showed lower stainability in biphasic and sarcomatoid MM. Besides, both IHCs showed significantly higher stainability for RhoA and vigilin in epithelioid MM than in LAC and LSC (p < 0.05). Chi-square tests showed that both RhoA and vigilin IHC positive rate in epithelioid MM was not significantly different from that of calretinin (p > 0.05). In the differential diagnosis of MM from lung cancer, the accuracy and specificity of RhoA, vigilin, and calretinin staining were almost equivalent. Further, H-score test showed that there was no significant difference between RhoA versus calretinin and vigilin versus calretinin in IHC positivity in epithelioid MM (p > 0.05). In conclusion, RhoA and vigilin may be candidates for immunohistochemical markers for epithelioid MM.

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“…Asbestos-related parenchymal lung disease was reported in India for the first time in 2005, and lung cancer in 2015 3 36. Mesothelioma causally related to asbestos is now in epidemic proportions in many western countries 13 37–46. Based on extrapolation of available data in western countries, it is estimated that there are ~14 000 deaths annually due to mesothelioma that can be causally related to asbestos 47.…”

Section: Global Health Problem Analysismentioning

confidence: 99%

A case from India of pleural malignant mesothelioma probably due to domestic and environmental asbestos exposure: a posthumous report

Muralidhar¹,

Raghav

Das

et al. 2019

BMJ Case Rep

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India is the largest consumer of asbestos in the world. There is no report from India of mesothelioma related to asbestos. The case is a 42-year-old man who died of pleural mesothelioma. He was exposed to asbestos domestically and from the environment since birth. Two of his close family members worked in a factory that used asbestos. The living quarter of the family was within the premises of the factory. Asbestos waste was strewn on the grounds surrounding the quarters. After decades of legal battles by workers and families exposed to asbestos, Indian courts have ordered remedial measures and compensation to people, who are exposed to asbestos at work and the environment. Mesothelioma, currently in epidemic proportions in the west where asbestos production was banned in the 1990s, could rise to alarming levels in the next decades in India if the legal remedial measures are not implemented soon.

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Differences between peritoneal and pleural mesothelioma in Lombardy, Italy

Cited by 11 publications

References 17 publications

Peritoneal mesothelioma and asbestos exposure: a population-based case–control study in Lombardy, Italy

Peritoneal mesothelioma and asbestos exposure: a population-based case–control study in Lombardy, Italy

RhoA and vigilin are candidates for immunohistochemical markers for epithelioid malignant mesothelioma

A case from India of pleural malignant mesothelioma probably due to domestic and environmental asbestos exposure: a posthumous report

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