Differences between the Electrical Charge carried by Normal and Homologous Tumour Cells

Ambrose, E. J.; James, A. M.; Lowick, J. H. B.

doi:10.1038/177576a0

Cited by 235 publications

(54 citation statements)

References 6 publications

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“…Transformed and highly oncogenic cells have often been found to have a higher surface net negative charge than their non-transformed or normal counterparts [9]. In order to determine whether BrdUrd treatment altered net surface charge the electrophoretic mobility of BrdUrd, TdR, or non-treated cells was determined by observing the electrophoretic mobility of cells in an electric field.…”

Section: Resultsmentioning

confidence: 99%

Cell surface changes caused by growth of B16 melanoma cells in bromodeoxyuridine

et al. 1977

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Section: Resultsmentioning

confidence: 99%

Cell surface changes caused by growth of B16 melanoma cells in bromodeoxyuridine

et al. 1977

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“…(Dunham, Nichols and Brunschwig, 1946;de Long, Coman, an. Zeidman, 1950), decreased adherence (McCutcheon, Coman and, Moore, 1948), absence of contact inhibition (Abercrombie andHeaysman, 1953, 1954) and accelerated electrophoretic mobility (Ambrose, James and Lowick, 1956) have all been demonstrated. However the fundamental change underlying these has not yet been elucidated, and it remains to be shown whether any or all of them run parallel to the apparent changes in antigen-content.…”

Section: Discussionmentioning

confidence: 95%

A and B Antigens of Normal and Malignant Cells

Kay¹

1957

Br J Cancer

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“…Malignant cells are often more negatively charged than normal cells (Ambrose, James and Lowick, 1956). Assuming that this difference in charge might be useful for in vivo therapy, we have given either polycation or polyanion (a) to AKR mice which have a high incidence of spontaneous thymus lymphatic leukaemia (Dunn, 1954) and (b) to BALB/c mice infected with Rauscher leukaemia virus.…”

mentioning

confidence: 99%

Incidence of Nasopharyngeal Carcinoma in Malaysia, with Special Reference to the State of Selangor

Rw¹,

Mk²,

Sk³

1974

Br J Cancer

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Summary.-AKR mice of which more than 900,, die of lymphatic thymus leukaemia, had their mean survival time increased by weekly intraperitoneal inoculation of either of the two polycations DEAE-dextran and polybrene. Administration of the neutral dextran had no effect, whereas the polyanion dextran sulphate accelerated leukaemia development.Adult BALB/c mice infected with Rauscher leukaemia virus and treated from the time of palpable spleen enlargement, showed a life prolonging effect of the polycations DEAE/dextran and polybrene, and of neutral dextran. BALB/c mice treated from the time of leukaemia infection, however, showed a life prolonging effect with polyanion dextran sulphate and also of neutral dextran.

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Differences between the Electrical Charge carried by Normal and Homologous Tumour Cells

Cited by 235 publications

References 6 publications

Cell surface changes caused by growth of B16 melanoma cells in bromodeoxyuridine

Cell surface changes caused by growth of B16 melanoma cells in bromodeoxyuridine

A and B Antigens of Normal and Malignant Cells

Incidence of Nasopharyngeal Carcinoma in Malaysia, with Special Reference to the State of Selangor

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