Differences between TNM classification and 2-[18F]FDG PET parameters of primary tumor in NSCLC patients

Cegła, Paulina; Bryl, Maciej; Witkowska, Kamila; Boś-Liedke, Agnieszka; Pietrasz, Katarzyna; Kycler, Witold; Malicki, J.; Piotrowski, Tomasz; Czepczyński, Rafał

doi:10.5603/rpor.a2021.0072

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…There are some limitations regarding the SUVmax value ın FDG-PET/CT scan. According to Cegla et al, the biggest limitation of using the SUVmax value is that it represents a single maximum pixel within the tumor without the possibility of reflecting metabolic activity within the entire tumor [ 25 ]. Tessonnier et al evaluated 23 patients without metastasis and 14 patients with a metastatic disease in order to determine the prognostic values of preoperative SUV in patients with ACC.…”

Section: Discussionmentioning

confidence: 99%

Role of 18F-fluorodeoxyglucose positron-emission tomography/computed tomography in restaging of adrenocortical carcinoma

Ozturk

2024

Rep Pract Oncol Radiother.

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Background The objective was to retrospectively evaluate the contribution of fluorodeoxyglucose [ 18 F] positron emission tomography/computed tomography ( 18 FDG-PET/CT) to the re-staging of adrenocortical carcinoma (ACC). Materials and methods A total of 16 patients (10 males and 6 females), who underwent adrenalectomy due to adrenocortical carcinoma and 18 FDG-PET/CT scan to re-stage the tumor between July 2007 and April 2013, were included in the present study. The mean age was 53.37 ± 13.91 years (min: 30, max: 74) The patients were required to fast for six hours prior to scanning, and whole-body PET scanning from the skull base to the upper thighs was performed approximately 1 h after the intravenous injection of 555 MBq of F-18 FDG. Whole body CT scanning was performed in the cranio-caudal direction. FDG-PET images were reconstructed using CT data for attenuation correction. Suspicious recurrent or metastatic lesions were confirmed by histopathology or clinical follow-up. Results Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 18 FDG-PET/CT were 100%, 83.3%, 90.9%, 83.3%, and 93.7%, respectively. Conclusion 18 FDG-PET/CT detects local recurrence and/or distant metastases with high accuracy in the re-staging of operated adrenocortical carcinoma. It is considered that the procedure could play an important role in treatment decision after the operation and post-operative follow-up and could influence the entire decision-making process.

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Section: Discussionmentioning

confidence: 99%

Role of 18F-fluorodeoxyglucose positron-emission tomography/computed tomography in restaging of adrenocortical carcinoma

Ozturk

2024

Rep Pract Oncol Radiother.

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“…Overall survival is highly dependent on the stage of the disease and, according to some authors, preoperative [ 18 F]FDG uptake in primary tumor is associated with OS and time to recurrence (TTR) [2,4]. Moreover, an [ 18 F]FDG PET-derived parameters provide additional information to the TNM stage, especially metabolic parameters of the tumor expressed with metabolic tumor volume (MTV) and total lesion glycolysis (TLG) vary with TNM stage and thus can be used as a biological description system for lung cancer [5].…”

Section: Introductionmentioning

confidence: 99%

Value of [18F]FDG PET/CT parameters of the primary tumor in assessing overall survival in NSCLC patients with cN1-cN3 lymph nodes involvement

Cegla,

Hofheinz,

Czepczyński

et al. 2024

Rep Pract Oncol Radiother.

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Background:The aim of this retrospective study was to assess the value of 18 F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography ([ 18 F]FDG PET/CT parameters in cN1-cN3 non-small cell lung cancer (NSCLC) patients.Materials and methods: 59 consecutive patients (35 M, 24 F) with NSCLC who underwent pretreatment [ 18 F]FDG PET/CT were enrolled to this study. Several primary tumor PET parameters, including the maximum and mean standardized uptake value (SUV max and SUV mean) , the metabolic active tumor volume (MTV) and the total lesion glycolysis (TLG = MTVxSUV mean ), were extracted and analysed. Overall survival was defined as time from primary diagnosis to death or the last info. Results:In the whole analysed group 44 patients underwent curative treatment, while 15, because of the severity of the disease, were classified for palliative treatment. Univariate Cox analysis of clinical and metric PET parameters revealed that MTV was a significant prognostic factor for OS (p = 0.024), while TLG and curative treatment showed a trend for significance (p < 0.1). In multivariate Cox regression (MTV and curative treatment) MTV remained a significant factor (p = 0.047).Conclusions: Metabolic tumor volume of the primary tumor was the only independent prognostic factor for cN1-cN3 NSCLC patients.

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Differences between TNM classification and 2-[18F]FDG PET parameters of primary tumor in NSCLC patients

Cited by 2 publications

References 22 publications

Role of 18F-fluorodeoxyglucose positron-emission tomography/computed tomography in restaging of adrenocortical carcinoma

Role of 18F-fluorodeoxyglucose positron-emission tomography/computed tomography in restaging of adrenocortical carcinoma

Value of [18F]FDG PET/CT parameters of the primary tumor in assessing overall survival in NSCLC patients with cN1-cN3 lymph nodes involvement

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