1985
DOI: 10.1093/jac/15.2.201
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Differences in ability of cell-wall antibiotics to suppress emergence of rifampicin resistance in Staphyloccocus aureus

Abstract: Rifampicin resistance developed easily in methicillin-susceptible and methicillin-resistant strains of Staphylococcus aureus during an overnight incubation in broth containing 0.1 mg/l of rifampicin. Incubation of methicillin-susceptible Staph. aureus and 0.1 mg/l of rifampicin with 1 mg/l of nafcillin reduced the emergence of rifampicin resistance with only 5 of 50 strains (10%) becoming rifampicin-resistant. However, incubation of the methicillin-susceptible or methicillin-resistant strains with 0.1 mg/l of … Show more

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Cited by 31 publications
(18 citation statements)
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“…Although rifampin alone is not recommended for the treatment of staphylococcal infections because of the rapid emergence of resistant strains, the addition of rifampin to a beta-lactam may render MR strains more susceptible to beta-lactams by decreasing the production of PBP 2a. Thus, the observed increased synergistic activity of cefpirome and rifampin compared with that of cefazolin and rifampin may be due to the better antistaphylococcal activity of cefpirome rather than to the different ability to prevent emergence of rifampin resistance as previously described in vitro for different cell wall-active antimicrobial agents for S. aureus (14). Previous studies in our laboratory, however, demonstrated antagonism with the same rifampin-cephalosporin combinations in vivo in S. aureus experimental endocarditis (9).…”
Section: Discussionmentioning
confidence: 49%
“…Although rifampin alone is not recommended for the treatment of staphylococcal infections because of the rapid emergence of resistant strains, the addition of rifampin to a beta-lactam may render MR strains more susceptible to beta-lactams by decreasing the production of PBP 2a. Thus, the observed increased synergistic activity of cefpirome and rifampin compared with that of cefazolin and rifampin may be due to the better antistaphylococcal activity of cefpirome rather than to the different ability to prevent emergence of rifampin resistance as previously described in vitro for different cell wall-active antimicrobial agents for S. aureus (14). Previous studies in our laboratory, however, demonstrated antagonism with the same rifampin-cephalosporin combinations in vivo in S. aureus experimental endocarditis (9).…”
Section: Discussionmentioning
confidence: 49%
“…Kill-curve studies of the five most effective antibiotics showed good killing of the test strains within 8 h; however, at 24 h complete regrowth to a density greater than the initial inoculum occurred with rifampin, and partial regrowth occurred with coumermycin. Despite the high level of inhibitory activity of rifampin, rapid emergence of resistance to rifampin by Metr S. aureus has been reported by other investigators (1,9,22). Vancomycin, teicoplanin, and ciprofloxacin were highly bactericidal at 24 h, killing greater than 98% of the inoculum.…”
Section: Discussionmentioning
confidence: 91%
“…There have been many in vitro studies performed for rifampin-vancomycin combination therapy (217). With MSSA isolates, nafcillin combined with rifampin demonstrated superiority to vancomycin in suppressing the emergence of rifampin-resistant isolates (78). Another concern with the rifampin-vancomycin combination is that each drug penetrates tissue differently based on kinetics.…”
Section: Staphylococcimentioning
confidence: 99%