“…Although community surveys of transgender persons in the United States have found a high prevalence of depression, anxiety, and substance use relative to that of the general adult US population, 4,5,8–10,12–16 studies typically use screening instruments or subthreshold symptom questions and do not use diagnostic interviews, such as the Mini-International Neuropsychiatric Interview (MINI), to assess prevalence of mental health psychopathology and substance dependence, with one exception. 17 Acommunity sample of 571 adult transgenderwomen 17 recruited from the NewYork City metropolitan area (mean age 37 years) used the MINI and found that life-time prevalence of depressionwas54.3%, nearly 3 times higher than the corresponding National Comorbidity Survey estimate for the general population, 19.6% 18 ; lifetime suicide ideation was 53.5% (more than 3 times higher than the corresponding National Comorbidity Survey estimate in the general population, 13.5%), and lifetime suicide plans and attempts (35.0%and 27.9%, respectively)were 7 to 10times higher than corresponding National Comorbidity Survey estimates (3.9% and 4.6%, respectively).…”