Differences in Average Serum Cortisol Levels and Serum 25 Hydroxyvitamin D Levels in Preeclampsia and Normal Pregnancy

Abstract

According to the World Health Organization, hypertension ranks second as the direct cause of maternal death in pregnancy; namely gestational hypertension (14%). Causes of maternal death in 2021 related to hypertension in pregnancy totaling 1,077 cases. Preeclampsia involves a number of biological processes that affect immune dysfunction, placental implantation, abnormal angiogenesis, excessive inflammation and high oxidative stress reactions and diseases related to maternal vascularization or blood vessels are possible contributing causes. Research with a case-control design was conducted at RSUP Dr. M. Djamil, RSIA Siti Hawa, and RSIA Cicik Padang from February 2021–August 2022. Preeclampsia and normal pregnancy research samples consisted of 27 case samples and 27 control samples. Serum cortisol levels and serum 25-hydroxyvitamin D levels were examined by the ELISA method. The Independent Sample T-Test was used to analyze the data. The mean difference in serum cortisol levels in preeclampsia was 48.70 ± 15.23 µg/dL, higher than that in normal pregnancy, 38.62 ± 8.27 µg/dL (p-value = 0.004, p <0.05). Differences The mean serum level of 25 Hydroxyvitamin D in preeclampsia was 13.63 ± 6.12 ng/ml, lower than that in normal pregnancy, 14.49 ± 3.94 ng/ml (p-value =0.539, p>0.05). The study concluded that there were differences in cortisol levels in preeclamptic pregnancies with normal pregnancies and there were no differences in serum levels of 25 Hydroxyvitamin D in preeclamptic pregnancies with normal pregnancies