Differences in Behavior among the Chlorides of Seven Rare Earth Elements Administered Intravenously to Rats

Nakamura, Yumiko; Tsumura, Yukari; Tonogai, Yasuhide; Shibata, Tadashi; Ito, Yoshio

doi:10.1093/toxsci/37.2.106

Cited by 76 publications

(42 citation statements)

References 20 publications

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“…The results showed the largest influence of Ce and La on viability and inflammatory response, followed by Pr and Nd. Especially the light REE La, Ce and Pr are known to be hepatotoxic by inducing fatty liver 17,48 . Pr is the most toxic element leading to animal death in comparable concentrations used for Ce, probably due to its low clearing rate 17 .…”

Section: Discussionmentioning

confidence: 99%

“…Especially the light REE La, Ce and Pr are known to be hepatotoxic by inducing fatty liver 17,48 . Pr is the most toxic element leading to animal death in comparable concentrations used for Ce, probably due to its low clearing rate 17 . However, a pretreatment with low doses can prevent the lethal effect nearly complete 49 .…”

Section: Discussionmentioning

confidence: 99%

“…These elements are chemically classified by their ionic radii in three groups: (I) light REE from La to Pr, (II) medium REE from Nd to Gd, and (III) heavy REE from Tb to Lu. Their ionic radii are close to that of calcium, therefore all of these elements can act as calcium anatagonist [16][17][18] . REE in magnesium alloying are predominantly used for strengthening and to improve corrosion resistance 19 .…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of short-term effects of rare earth and other elements used in magnesium alloys on primary cells and cell lines☆

Feyerabend¹,

Fischer²,

Holtz³

et al. 2010

Acta Biomaterialia

532

263

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Degradable magnesium alloys for biomedical application are on the verge of being used clinically. Rare earth elements (REE) are used to improve the mechanical properties of the alloys, however in more or less undefined mixtures. Therefore in this study the in vitro cytotoxicity of the elements yttrium (Y), neodymium (Nd), dysprosium (Dy), praseodymium (Pr), gadolinium (Gd), lanthanum (La), cerium (Ce), europium (Eu), lithium (Li), zirconium (Zr), was evaluated by incubation with the chlorides (10-2000 µM), magnesium (Mg) and calcium (Ca) were tested at higher concentrations (200 and 50 mM, respectively). The influence on viability of human osteosarcoma cell line MG-63, human umbilical cord perivascular (HUCPV) cells and mouse macrophages (RAW 264.7) was determined, as well as the induction of apoptosis and the expression of inflammatory factors (TNF-α, IL-1α). Significant differences between the applied cells could be observed. RAW exhibited the highest and HUCPV the lowest sensitivity. La and Ce showed the highest cytotoxicity of the analysed elements. From the elements with high solubility in magnesium alloys Gd and Dy seem to be more suitable than Y. The focus of magnesium alloy development for biomedical applications should include most defined alloy compositions with well known tissue specific and systemic effects.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of short-term effects of rare earth and other elements used in magnesium alloys on primary cells and cell lines☆

Feyerabend¹,

Fischer²,

Holtz³

et al. 2010

Acta Biomaterialia

532

263

View full text Add to dashboard Cite

show abstract

“…Hirona et al [21] studied the intratracheal instillation of YCl 3 in rats and found that Y was localized in lysosomes of alveolar and interstitial macrophages and basement membranes. YCl 3 instillation induces acute lung injury; however, it 512 Eco-Materials Processing and Design VIII persists in the lungs after instillation or intravenous delivery [22,23]. Chronic or sustained release of Y from SWNTs may produce chronic lung or systemic toxicity.…”

Section: The Role Of Catalytic Metalsmentioning

confidence: 99%

A Window of Opportunity: Designing Carbon Nanomaterials for Environmental Safety and Health

Guo

Liu

Sanchez

et al. 2007

MSF

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Abstract. Carbon nanomaterials are among the best known and most promising products of the nanotechnology movement. Some early studies suggest that fullerenes and nanotubes may pose significant health risks, and this has given rise to an emerging literature on carbon nanotoxicology. This young field has now begun to yield insight into toxicity mechanisms and the specific material features involved in those mechanisms. This paper explores the potential to alter those material features through post-processing or reformulation with the goal of reducing or eliminating carbon nanomaterial health risks. The paper emphasizes the important roles of metal content and bioavailability, carbon surface chemistry, and nanomaterial aggregation state. The nanotechnology movement has been given a unique "window of opportunity" to systematically investigate the toxicity of nanotechnology products and to develop ways to manage health risks before large scale manufacturing becomes widespread.

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“…It is obvious that Al is harmful to neuron 9) and Re will lead to hepatotoxicity 10) . Zn and Ca are important elements in the body.…”

Section: Introductionmentioning

confidence: 99%

Microstructure, Mechanical Properties, In Vitro Degradation and Cytotoxicity of Mg-4Zn-3HA Alloy for Biodegradable Implant Materials

Yang

Zhai

et al. 2014

J. Hard Tissue Biology.

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In this study, a kind of Mg-4Zn-3HA alloy was investigated as a biodegradable material. Magnesium alloys can be totally degraded in the body, and their corrosion products are not deleterious to the surrounding tissues. We conducted a comprehensive investigation of the microstructure, mechanical properties, in vitro degradation assessments, and in vitro cytotoxicity evaluations of Mg-4Zn-3HA alloy. Our observations of the microstructure show that the Mg-4Zn-3HA alloy is porous, and its structural characteristic resembling nature bone make this alloy suitable for use in implants. The results of in vitro degradation indicate that the corrosion resistance is improved with the extension of immersion time, and XRD and EDS analysis proves that the corrosion products on the surface of Mg-4Zn-3HA alloy contain hydroxyapatite (HA), Mg (OH) 2 and other magnesium-substituted calcium phosphate, which could reduce the degradation rate. The degradation process of magnesium alloy and the formation of corrosion layer are also discussed in this work. The corrosion products contain HA and Mg (OH) 2 , which can promote good biocompatibility. No significant cytotoxicity to MC3T3-E1 cells is detected in the extraction medium, and MC3T3-E1 cells are able to adhere and spread on the corrosion layer of the Mg-4Zn-3HA alloy. Mg-4Zn-3HA alloys have the potential to be used for biomedical applications.

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Differences in Behavior among the Chlorides of Seven Rare Earth Elements Administered Intravenously to Rats

Cited by 76 publications

References 20 publications

Evaluation of short-term effects of rare earth and other elements used in magnesium alloys on primary cells and cell lines☆

Evaluation of short-term effects of rare earth and other elements used in magnesium alloys on primary cells and cell lines☆

A Window of Opportunity: Designing Carbon Nanomaterials for Environmental Safety and Health

Microstructure, Mechanical Properties, In Vitro Degradation and Cytotoxicity of Mg-4Zn-3HA Alloy for Biodegradable Implant Materials

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