Differences in body fat distribution assessed by ultrasonography in patients receiving antiretroviral drugs

Signorini, Dario José Hart Pontes; Netto, Ana Maria Schmidt de Oliveira; Monteiro, Michelle Carreira Miranda; Signorini, Dario Hart; Codeço, Cláudia Torres; Bastos, Francisco Inácio; Gabbay, Sergio; Andrade, Marion de Fátima Castro de

doi:10.1016/s0104-4230(12)70180-x

Cited by 6 publications

(2 citation statements)

References 24 publications

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“…Developing a material that serves as a biocompatible long‐term filler, and is amenable to injectable administration, has the potential to transform soft tissue augmentation and reconstruction. The many who may benefit from such a product include individuals who have undergone tumor resections, those with congenital defects (e.g., cleft lips) and other genetic disorders (e.g., Parry Romberg syndrome), patients who are suffering from lipoatrophy associated with HIV infection and the effects of anti‐HIV drugs, blast victims, and soldiers with traumatic combat injuries . The number of surgical reconstructive procedures is increasing, reaching a high of 5.6 million procedures in 2012; the most prominent in this category are associated with tumor removals, at 4.2 million…”

Section: Introductionmentioning

confidence: 99%

Injectable redox-polymerized methylcellulose hydrogels as potential soft tissue filler materials

Gold

Varma

Harbottle

et al. 2014

J. Biomed. Mater. Res.

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There is a significant clinical need for long-lasting, injectable materials for soft tissue reconstruction. Methylcellulose (MC) is an FDA-approved polysaccharide derivative of cellulose that is inexpensive, renewable, and biocompatible, and may serve as an alternative to existing synthetic and natural fillers. In this study, MC was modified with functional methacrylate groups and polymerized using a redox-initiation system to produce hydrogels with tunable properties. By varying the percent methacrylation and macromer concentration, the equilibrium moduli of the hydrogels were found to range between 1.29 ± 0.46 and 12.8 ± 2.94 kPa, on par with human adipose tissue, and also displayed an inverse relationship to the swelling properties. Rheological analyses determined gelation onset and completion to be in accordance with the ISO standard for injectable materials. Cellulase enzymatic treatment resulted in complete degradation of the hydrogels by 48 h, presenting the possibility of minimally invasive removal of the materials in the event of malposition or host reaction. In addition, co-culture experiments with human dermal fibroblasts showed the gels to be cytocompatible based on DNA measurements and Live/Dead staining. Taken together, these redox-polymerized MC hydrogels may be of use for a wide range of clinical indications requiring soft tissue augmentation.

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Section: Introductionmentioning

confidence: 99%

Injectable redox-polymerized methylcellulose hydrogels as potential soft tissue filler materials

Gold

Varma

Harbottle

et al. 2014

J. Biomed. Mater. Res.

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show abstract

“…Lipoatrophy in human immunodeficiency virus (HIV) infected patients is a medical term which is used for loss of subcutaneous body fat in the face and extremity region ( 1 , 2 ). A wide range of lipoatrophy prevalence in different studies is a result of subjective criteria including personal evaluation of examinees, evaluation of physicians, and a variety of methods and measurement techniques ( 3 ). Despite numerous studies, objective criteria for the diagnosis of lipoatrophy have not yet been established ( 4 , 5 ).…”

Section: Introductionmentioning

confidence: 99%

Reversibility of Lipoatrophy in HIV-Infected Patients Taking Antiretroviral Therapy: a Cohort Study with Ultrasound Assessment

Zadro

2022

acc

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The aim of this study was to characterize and compare changes in subcutaneous fat in the malar, brachial and crural region in a cohort of HIV-infected patients taking antiretroviral therapy. This prospective longitudinal study included 77 patients who were selected from the initial cohort evaluated in 2007 and 2008. We examined reversibility of lipoatrophy measured by ultrasound over at least five-year period and factors related to its reversibility. All 46 patients who used stavudine switched from stavudine to another combination. Of 58 patients on zidovudine, 16 (28%) were on a zidovudine based regimen at the second follow up. There was evidence for subcutaneous fat increase in the malar area (p<0.001) and no increase in the brachial and crural areas. Patients who were smokers and had poor adherence to the Mediterranean diet had a thinner malar area at the follow up measurement (p=0.030) and smaller increase in subcutaneous malar fat compared to others (p=0.040). Our study suggested that modest increase of subcutaneous fat in malar area coincided with stopping stavudine and fewer usage of zidovudine. Lifestyle with non-adherence to the Mediterranean diet and smoking were associated with a smaller increase in subcutaneous malar fat.

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HIV-Infected Patients With and Without Lipodystrophy Under Combined Antiretroviral Therapy: Evaluation of Body Composition

Grenha

Oliveira

Lau

et al. 2018

Journal of Clinical Densitometry

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Differences in body fat distribution assessed by ultrasonography in patients receiving antiretroviral drugs

Cited by 6 publications

References 24 publications

Injectable redox-polymerized methylcellulose hydrogels as potential soft tissue filler materials

Injectable redox-polymerized methylcellulose hydrogels as potential soft tissue filler materials

Reversibility of Lipoatrophy in HIV-Infected Patients Taking Antiretroviral Therapy: a Cohort Study with Ultrasound Assessment

HIV-Infected Patients With and Without Lipodystrophy Under Combined Antiretroviral Therapy: Evaluation of Body Composition

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