Differences in body fat distribution and antioxidant status in Korean men with cardiovascular disease with or without diabetes

Jang, Yangsoo; Lee, Jong Ho; Cho, Eun Young; Chung, Nam Sik; Topham, Debra; Balderston, Brenda

doi:10.1093/ajcn/73.1.68

Cited by 19 publications

(14 citation statements)

References 40 publications

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“…Cross-sectional studies have demonstrated an association between low testosterone (T) and T2DM since the early 1980s (Daubresse et al, 1978;Shahwan et al, 1978;Andò et al, 1984;Phillips, 1984;Small et al, 1987;Semple et al, 1988;Barrett-Connor et al, 1990;Barrett-Connor, 1992;Andersson et al, 1994;Tibblin et al, 1996;Defay et al, 1998;Chearskul et al, 2000;Zietz et al, 2000;Jang et al, 2001;Abou-Seif & Youssef, 2001;Abate et al, 2002;Corona et al, 2004;Corrales et al, 2004;Dhindsa et al, 2004;Svartberg et al, 2004b;Achemlal et al, 2005;Pitteloud et al, 2005;Rhoden et al, 2005;Chen et al, 2006;Corona et al, 2006;Crawford et al, 2007;Kapoor et al, 2007a;Selvin et al, 2007;Ibáñez et al, 2008;Hamdan & Al-Matubsi, 2008;Corona et al, 2009a,b). Accordingly, a previous meta-analysis (Ding et al, 2006) of available cross-sectional studies indicated that total testosterone (TT) was significantly lower in men with T2DM.…”

Section: Discussionmentioning

confidence: 99%

“…This possibility is consistent with recent clinical evidence. Pitteloud et al (2005), demonstrated that testosterone levels were positively 86 -13.26 -4.70 -0.65 -20.15 -10.40 -5.15 -27.45 -16.30 -0.58 -8.22 -4.40 Overall Selvin et al, 2007Svartberg et al, 2004Abate et al, 2002Jang et al, 2001Tibblin et al, 1996Andersson et al, 1994Barret-Connor et al, 1990 FT lower in T2DM Tibblin et al, 1996 -6.12 -12.22 -9.17 4.80 -22.60 -8.90 -5.67 -14.33 -10.00 3.72 -9.32 -2.80 -3.74 -8.26 -6.00 -5.34 -10.66 -8.00 -1.60 -20.40 -11.00 -13.81 -34.59 -24.20 -8.91 -60.29 -34.60 -3.04 -17.36 -10.20 -6.12 correlated with insulin sensitivity, measured with a hyperinsulinaemic-euglycaemic clamp, independently of body composition. Similar results were reported by Muller et al (2005).…”

Section: Tt Lower In T2dmmentioning

confidence: 98%

“…TT higher in T2DM Daubresse et al, 1978Shahwan et al, 1978Andò et al, 1984Phillips, 1984Small et al, 1987Semple et al, 1988Barret-Connor et al, 1990Barret-Connor, 1992Andersson et al, 1994Tibblin et al,1996Defay et al, 1998* Defay et al, 1998** Chearskul et al, 2000Jang et al, 2001Zietz et al, 2000Abou-Seif et al, 2001Corrales et al, 2004Svartberg et al, 2004Achemlal et al, 2005Chen et al, 2005Pitteloud et al, 2005Crawford et al, 2007Selvin et al, 2007Ibanez et al, 2008 Overall no ED Daubresse et al, 1978Shahwan et al, 1978Corona et al, 2004Corona et al, 2005Rhoden et al, 2005Hamdan et al, 2008 Overall ED Overall Diff. in means LL, 95% CI Figure 2 Weighted differences (with 95% confidence interval) of mean total testosterone between type 2 diabetes mellitus and controls from cross-sectional studies.…”

Section: Tt Lower In T2dmmentioning

confidence: 99%

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Type 2 diabetes mellitus and testosterone: a meta-analysis study

Corona

Monami

Rastrelli

et al. 2010

International Journal of Andrology

333

273

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Several studies suggest that type 2 diabetes mellitus (T2DM) is often associated with male hypogonadism. Despite the well-known link, the role of testosterone replacement therapy (TRT) in T2DM has not been completely clarified. The aim of the present study was to analyse systematically the relationship between androgen levels and T2DM by reviewing and meta-analysing available prospective and cross-sectional studies. In addition, a specific meta-analysis on the metabolic effects of TRT in available randomized clinical trials (RCTs) was performed. An extensive Medline search was performed including the following words: 'testosterone', 'type 2 diabetes mellitus' and 'males'. Of 742 retrieved articles, 37 were included in the study. In particular 28, 5 and 3 were cross-sectional, longitudinal and interventional studies, respectively. A further unpublished RCT was retrieved from http://www.clinicaltrials.gov. T2DM patients showed significantly lower testosterone plasma levels in comparison with non-diabetic individuals. Similar results were obtained when T2DM subjects with and without erectile dysfunction were analysed separately. Meta-regression analysis demonstrated that ageing reduced, while obesity increased, these differences. However, in a multiple regression model, after adjusting for age and body mass index (BMI), T2DM was still associated with lower total testosterone (TT) levels (adjusted r = -0.568; p < 0.0001). Analysis of longitudinal studies demonstrated that baseline TT was significantly lower among patients with incident diabetes in comparison with controls (HR = -2.08[-3.57;-0.59]; p < 0.001). Combining the results of RCTs, TRT was associated with a significant reduction in fasting plasma glucose, HbA1c, fat mass and triglycerides. Conversely, no significant difference was observed for total and high-density lipoprotein cholesterol, blood pressure and BMI. The meta-analysis of the available cross-sectional data suggests that T2DM can be considered independently associated with male hypogonadism. Although only few RCTs have been reported, TRT seems to improve glycometabolic control as well as fat mass in T2DM subjects.

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Section: Discussionmentioning

confidence: 99%

Section: Tt Lower In T2dmmentioning

confidence: 98%

Section: Tt Lower In T2dmmentioning

confidence: 99%

See 1 more Smart Citation

Type 2 diabetes mellitus and testosterone: a meta-analysis study

Corona

Monami

Rastrelli

et al. 2010

International Journal of Andrology

333

273

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“…Low plasma levels of SHBG were found to be similarly strongly associated with insulin resistance and increased risk of type 2 diabetes, in men and in women in most (7–11), but not in all, studies (12–15). …”

mentioning

confidence: 95%

Relationships of Circulating Sex Hormone–Binding Globulin With Metabolic Traits in Humans

et al. 2010

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OBJECTIVERecent data suggested that sex hormone–binding globulin (SHBG) levels decrease when fat accumulates in the liver and that circulating SHBG may be causally involved in the pathogenesis of type 2 diabetes in humans. In the present study, we investigated mechanisms by which high SHBG may prevent development to diabetes.RESEARCH DESIGN AND METHODSBefore and during a 9-month lifestyle intervention, total body and visceral fat were precisely measured by magnetic resonance (MR) tomography and liver fat was measured by 1H-MR spectroscopy in 225 subjects. Insulin sensitivity was estimated from a 75-g oral glucose tolerance test (ISOGTT) and measured by a euglycemic hyperinsulinemic clamp (ISclamp, n = 172). Insulin secretion was measured during the OGTT and an ivGTT (n = 172).RESULTSSHBG levels correlated positively with insulin sensitivity (ISOGTT, P = 0.037; ISclamp, P = 0.057), independently of age, sex, and total body fat. In a multivariate model, these relationships were also significant after additional adjustment for levels of the adipokine adiponectin and the hepatokine fetuin-A (ISOGTT, P = 0.0096; ISclamp, P = 0.029). Adjustment of circulating SHBG for liver fat abolished the relationships of SHBG with insulin sensitivity. In contrast, circulating SHBG correlated negatively with fasting glycemia, before (r = −0.17, P = 0.009) and after (r = −0.14, P = 0.04) adjustment for liver fat. No correlation of circulating SHBG with adjusted insulin secretion was observed (OGTT, P = 0.16; ivGTT, P = 0.35). The SNP rs1799941 in SHBG was associated with circulating SHBG (P ≤ 0.025) but not with metabolic characteristics (all P > 0.18).CONCLUSIONSPossible mechanisms by which high circulating SHBG prevents the development of type 2 diabetes involve regulation of fasting glycemia but not alteration of insulin secretory function.

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“…The differences in visceral fat accumulation and antioxidant status were determined in 64 healthy Korean men and in 56 CAD Korean men with or without diabetes [7]. Findings revealed a significantly greater amount of visceral fat in CAD men with diabetes than in healthy men at both L1 and L4 vertebras.…”

Section: Body Fat Distribution and Antioxidant Status In Cad Men Withmentioning

confidence: 99%

Dietary habits, obesity status and cardiovascular risk factors in Koreans

Lee

Jang

Kim

2004

International Congress Series

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Differences in body fat distribution and antioxidant status in Korean men with cardiovascular disease with or without diabetes

Abstract: The concurrent presence of CVD and diabetes is associated with a greater negative effect on the risk factors typically associated with significant declines in health status.

Cited by 19 publications

References 40 publications

Type 2 diabetes mellitus and testosterone: a meta-analysis study

Type 2 diabetes mellitus and testosterone: a meta-analysis study

Relationships of Circulating Sex Hormone–Binding Globulin With Metabolic Traits in Humans

Dietary habits, obesity status and cardiovascular risk factors in Koreans

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