Differences in brain volume and thickness in patients with pulmonary or spine tuberculosis (TB) compared to non-TB individuals: A cross-sectional retrospective study

Majrashi, Naif A.; Khardali, Abdullah H.; Aqeeli, Hassan; Sallam, Waseem; Hakami, Ahmed; Qumairi, Amal; Hakamy, Ali; Alyami, Ali S.; Ageeli, Wael A.; Refaee, Turkey A.

doi:10.1016/j.heliyon.2023.e22199

Heliyon

2023

DOI: 10.1016/j.heliyon.2023.e22199

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Differences in brain volume and thickness in patients with pulmonary or spine tuberculosis (TB) compared to non-TB individuals: A cross-sectional retrospective study

Naif A. Majrashi,

Abdullah H. Khardali,

Hassan Aqeeli

et al.

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2024

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Cited by 2 publications

References 41 publications

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Associations of haematological and inflammatory biomarkers with brain volume in patients with sickle cell anaemia: A cross‐sectional retrospective study

Majrashi,

Hendi,

Dhayihi

et al. 2024

Tropical Med Int Health

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Sickle cell disease is a genetic disorder characterised by abnormal haemoglobin production. This study aims to investigate the associations between haematological and inflammatory biomarkers and brain volumes in patients with sickle cell anaemia and compare brain structure between patients with sickle cell anaemia and healthy controls. This retrospective cross‐sectional study included 130 participants (70 sickle cell anaemia patients and 60 healthy controls) who underwent brain MRI examinations at King Fahad Central Hospital between January 2010 and October 2022. Demographic data and haematological and inflammatory biomarkers were collected to examine their relationships with brain volumes. Brain volumes were measured using FreeSurfer. Specific haematological and inflammatory biomarkers were correlated with brain volume in patients with sickle cell anaemia, p < 0.05. Sickle cell anaemia patients exhibited smaller volumes in the brainstem, corpus callosum and amygdala compared to healthy controls. Males had significantly higher iron levels (p < 0.001) and larger various brain structure volumes (p < 0.05) than females. This study demonstrates significant associations between specific biomarkers and brain volume in sickle cell anaemia patients, underscoring the importance of monitoring these biomarkers for early detection and management of neurological complications in sickle cell anaemia.

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Associations of haematological and inflammatory biomarkers with brain volume in patients with sickle cell anaemia: A cross‐sectional retrospective study

Majrashi,

Hendi,

Dhayihi

et al. 2024

Tropical Med Int Health

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Brain Morphometry Differences Between Children With Autism Spectrum Disorder and Healthy Individuals in a Middle Eastern Population: A Cross‐Sectional Retrospective Study

Majrashi,

Mohtasib,

Masawi

et al. 2024

Acta Neurologica Scandinavica

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This study is aimed at investigating brain morphometry differences between children with ASD and healthy controls (HCs) in Saudi Arabia and exploring the association between IQ levels and brain volumes within the ASD group. Participants (N = 29, 31.1% females and 68.9% males) ranging in age from 6 to 17 years were scanned by MRI at the King Faisal Specialist Hospital and Research Center (KFSHRC). Brain volumes were analyzed while correcting for age, sex, and total intracranial volume (TICV). The analysis revealed that individuals with ASD exhibited larger volumes compared to HCs in the left caudate (p < 0.001), right caudate (p < 0.001), total caudate (p < 0.001), and total hippocampus (p = 0.014). These findings provide evidence for anatomical brain abnormalities in individuals with ASD and highlight the heterogeneity of these differences across brain regions. Furthermore, the analysis revealed that higher IQ levels were negatively associated with the volumes of the left thalamus, left pallidum, left accumbens area, right thalamus, right hippocampus, and total thalamus but positively correlated with the third lateral ventricle volume in HCs, p < 0.05. These results suggest a meaningful relationship between cognitive abilities, as measured by IQ, and variations in brain volumes in HCs. The study significantly contributes to the understanding of the neurobiology of ASD in a Middle Eastern population and emphasizes the importance of considering cognitive functioning in relation to brain morphology in ASD research and clinical practice.

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Differences in brain volume and thickness in patients with pulmonary or spine tuberculosis (TB) compared to non-TB individuals: A cross-sectional retrospective study

Cited by 2 publications

References 41 publications

Associations of haematological and inflammatory biomarkers with brain volume in patients with sickle cell anaemia: A cross‐sectional retrospective study

Associations of haematological and inflammatory biomarkers with brain volume in patients with sickle cell anaemia: A cross‐sectional retrospective study

Brain Morphometry Differences Between Children With Autism Spectrum Disorder and Healthy Individuals in a Middle Eastern Population: A Cross‐Sectional Retrospective Study

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