Differences in Callosal and Forniceal Diffusion between Patients with and without Postconcussive Migraine

Alhilali, Lea; Delic, Joseph; Fakhran, Saeed

doi:10.3174/ajnr.a5073

Cited by 29 publications

(20 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This same association of FA alterations in the fornix-hippocampal pathway and declining verbal memory scores has previously been found in concussed individuals, suggesting that neural networks involving memory are susceptible to injury, and that these alterations in our subjects might be related to repetitive neurotrauma. 24 …”

Section: Discussionmentioning

confidence: 99%

White Matter Changes Related to Subconcussive Impact Frequency during a Single Season of High School Football

Kuzminski

Clark

Fraser

et al. 2017

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

Background and Purpose The effect of exposing the developing brain of a high school football player to subconcussive impacts over the course of a single season is unknown. The purpose of this pilot study was to utilize MRI diffusion tensor imaging to assess white matter changes over the course of a single high school football season, and to correlate these changes with impacts measured by helmet accelerometer data and neurocognitive test scores collected over the same time period. Materials and Methods Seventeen male athletes (mean age 16 ± 0.73 years) underwent MRI scanning before and after the season. Changes in fractional anisotropy across the white matter skeleton were assessed with tract-based spatial statistics and region-of-interest (ROI) analysis. Results The mean number of impacts over a 10g threshold sustained was 414 (±291). Voxel-wise analysis failed to show significant changes in FA across the season, nor a correlation with impact frequency, after correcting for multiple comparisons. ROI analysis showed significant (p<0.05, corrected) decreases in FA in the fornix – stria terminalis (FXST) and cingulum hippocampus (CGH), which were related to impact frequency. The effects were strongest in the FXST, where decreases in FA correlated with worsening visual memory. Conclusion Our findings suggest that subclinical neurotrauma related to participation in American football may result in white matter injury, and that alterations in white matter tracts within the limbic system may be detectable after only one season of play at the high school level.

show abstract

Section: Discussionmentioning

confidence: 99%

White Matter Changes Related to Subconcussive Impact Frequency during a Single Season of High School Football

Kuzminski

Clark

Fraser

et al. 2017

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

“…DTI findings that could be specific for post‐traumatic headache were investigated by comparing patients who had post‐traumatic headache and other postconcussion symptoms to patients who had postconcussion symptoms without headache. Those with post‐traumatic headache had patterns of white matter injury in the corpus callosum and the fornix that differed from those patients without post‐traumatic headache . This is an interesting finding, as white matter diffusion changes in the corpus callosum have also been identified in patients with migraine, and there is some evidence that migraine frequency might modulate white matter integrity in the corpus callosum .…”

Section: Introductionmentioning

confidence: 81%

Research Imaging of Brain Structure and Function After Concussion

Chong

Schwedt

2018

Headache

View full text Add to dashboard Cite

Even when concussions are associated with prolonged physical and cognitive sequelae, concussions are typically "invisible" on diagnostic brain imaging, indicating that the neuropathology associated with concussion lies under the detection threshold of routine imaging. However, data from brain structural and functional research imaging studies using diffusion tensor imaging, resting-state functional magnetic resonance imaging, and brain perfusion imaging indicate that these imaging sequences have a role in identifying concussion-related neuropathology. These advanced imaging techniques provide insights into concussion neuropathology and might be useful for differentiating concussed patients from healthy controls. In this review article, we provide an overview of research findings from brain structural and functional imaging studies of concussion, and discuss the accuracy of classification models developed via machine-learning algorithms for identifying individual patients with concussion based on imaging data.

show abstract

“…Neuroimaging studies in persistent PTH have been performed to establish the brain structural [37][38][39][40][41] and functional changes [42][43][44][45] that could explain its pathophysiology, these include structural changes of the brain volume and density by voxel-based morphometry [25,37] and brain thickness [38]. The white matter changes were studied by DTI measuring decreased fractional anisotropy, mean diffusivity and radial diffusivity and establishing the fiber tract profiles [24,39]. The gray matter changes in persistent PTH were measured by gray matter volume [40] and voxel-based morphometry [37].…”

Section: Neuroimaging Studiesmentioning

confidence: 99%

“…The functional changes in the brain associated with persistent PTH were studied using default mode network [42], resting state MRI with static and dynamic functional connectivity [43], perfusion weighted imaging [46], CBF [45] and proton spectroscopy [44]. Some studies compare persistent PTH with healthy controls [25,[37][38][39][40][41][42][43][44][45] and others with migraine patients [24,25,43,45]. The studies that have compared persistent PTH with migraine, found structural [25,38] and functional brain changes [43] between groups, which suggest that migraine and persistent PTH have different pathophysiologic mechanisms.…”

Section: Neuroimaging Studiesmentioning

confidence: 99%

“…Alhilali et al compared DTI studies of 58 patients with acute or persistent PTH of a migraine phenotype with unknown pre-existing headache history, with 17 patients with mild TBI without headache [39]. It was found that patients with headache had decreased fractional anisotropy in the corpus callosum and fornix/septohippocampal circuit [39].…”

Section: Neuroimaging Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Persistent post-traumatic headache: a migrainous loop or not? The clinical evidence

et al. 2020

View full text Add to dashboard Cite

Background: Headache is a common complication of traumatic brain injury. The International Headache Society defines post-traumatic headache as a secondary headache attributed to trauma or injury to the head that develops within seven days following trauma. Acute post-traumatic headache resolves after 3 months, but persistent posttraumatic headache usually lasts much longer and accounts for 4% of all secondary headache disorders. Main body: The clinical features of post-traumatic headache after traumatic brain injury resemble various types of primary headaches and the most frequent are migraine-like or tension-type-like phenotypes. The neuroimaging studies that have compared persistent post-traumatic headache and migraine found different structural and functional brain changes, although migraine and post-traumatic headache may be clinically similar. Therapy of various clinical phenotypes of post-traumatic headache almost entirely mirrors the therapy of the corresponding primary headache and are currently based on expert opinion rather than scientific evidence. Pharmacologic therapies include both abortive and prophylactic agents with prophylaxis targeting comorbidities, especially impaired sleep and post-traumatic disorder. There are also effective options for non-pharmacologic therapy of posttraumatic headache, including cognitive-behavioral approaches, onabotulinum toxin injections, lifestyle considerations, etc. Conclusion: Notwithstanding some phenotypic similarities, persistent post-traumatic headache after traumatic brain injury, is considered a separate phenomenon from migraine but available data is inconclusive. High-quality studies are further required to investigate the pathophysiological mechanisms of this secondary headache, in order to identify new targets for treatment and to prevent disability.

show abstract

Differences in Callosal and Forniceal Diffusion between Patients with and without Postconcussive Migraine

Cited by 29 publications

References 30 publications

White Matter Changes Related to Subconcussive Impact Frequency during a Single Season of High School Football

White Matter Changes Related to Subconcussive Impact Frequency during a Single Season of High School Football

Research Imaging of Brain Structure and Function After Concussion

Persistent post-traumatic headache: a migrainous loop or not? The clinical evidence

Contact Info

Product

Resources

About