Differences in carbachol dose, pain condition, and sex following lateral hypothalamic stimulation

Holden, Janean E.; Wang, E.; Moes, Jesse R.; Wagner, Monica; Maduko, A.; Jeong, Younhee

doi:10.1016/j.neuroscience.2014.04.020

Cited by 15 publications

(20 citation statements)

References 92 publications

(109 reference statements)

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“…We have previously shown that microinjection of carbachol into areas adjacent to the LH, including the ventral thalamus (Holden et al, 2014; Jeong & Holden, 2009a), the nigrostriatal bundle (Holden, Van Poppel, & Thomas, 2002) and the internal capsule (Holden et al, 2002, 2014; Holden, Farah, & Jeong, 2005) produces withdrawal latencies similar to baseline measurements. It has also been well-established that areas adjacent to the LH, including the PH (Jeong & Holden, 2009b; Jeong, Moes, Wagner, & Holden, 2012), the dorsal hypothalamic nucleus (Biagioni et al, 2013) and certain places in the thalamus (Son, Kim, Kim, & Lee, 2014) all produce antinociception.…”

Section: Discussionmentioning

confidence: 66%

“…Almost half of publications do not report the sex of rats and the rest use predominantly males (Fillingim, King, Ribeiro-Dasilva, Rahim-Williams, & Riley, 2009; Mogil & Chanda, 2005). Holden et al (2014) demonstrated sex differences as well as pain type differences for LH stimulation; however, testing both males and females is beyond the scope of the present study, which was not focused on sex differences, but on the pathway itself. Lack of male/female comparisons is a limitation and further comparisons of sex differences are needed regarding orexins and the orexins pathway.…”

Section: Discussionmentioning

confidence: 92%

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Lateral Hypothalamic Stimulation Reduces Hyperalgesia Through Spinally Descending Orexin-A Neurons in Neuropathic Pain

et al. 2015

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No evidence to date shows that lateral hypothalamic (LH) stimulation produces orexin-A mediated antinociception in the spinal cord dorsal horn (SCDH) in a model of neuropathic pain. We conducted experiments to examine the effect of orexin-A-mediated LH stimulation in female rats with chronic constriction injury (CCI) on thermal hyperalgesia. Rats receiving carbachol into the LH demonstrated antinociception on both the left CCI and right non-ligated paws (p < 0.05). Rats were given carbachol in the LH followed by intrathecal injection of the orexin-1 receptor (OX1) antagonist SB-334867, which blocked LH-induced antinociception compared to control groups (p < 0.05) in the left paw, but not in the right paw. These findings support the hypothesis that LH stimulation produces antinociception in rats with thermal hyperalgesia from neuropathic pain via an orexin-A connection between the LH and the SCDH. Identification of this pathway may lead to studies using orexins to manage clinical pain.

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 92%

Lateral Hypothalamic Stimulation Reduces Hyperalgesia Through Spinally Descending Orexin-A Neurons in Neuropathic Pain

et al. 2015

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“…Previous studies have revealed that intra‐LH injection of carbachol, a cholinergic receptor agonist, reduced nociceptive responses in the phasic, tonic and neuropathic pain models (Holden et al., ; Moradi et al., ,b; Ezzatpanah et al., ). Carbachol increases the firing rate of orexin neurons (Ohno et al., ).…”

Section: Discussionmentioning

confidence: 97%

Nucleus accumbens dopamine receptors mediate hypothalamus‐induced antinociception in the rat formalin test

Siahposht-Khachaki

Pourreza

Ezzatpanah

et al. 2017

European Journal of Pain

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Background: Lateral hypothalamus (LH) involves in modulation of tonic pain. Regarding the direct and indirect neural connections between the LH and nucleus accumbens (NAc), we aimed to examine the pain modulatory role of NAc dopamine receptors in modulation of LH-induced analgesia in the formalin test. Methods: Vehicle-control groups received saline or DMSO into the NAc and saline into the LH. Carbachol-control groups received carbachol (250 nmol/L) into the LH, 5 min after saline or DMSO injection into the NAc. In treatment groups, intra-NAc administration of SCH-23390 or sulpiride (D1-and D2-like dopamine receptor antagonists, respectively) was performed 5 min before carbachol injection. Formalin test was done in all rats 5 min after the second injection. Results: The blockade of NAc dopamine receptors reduced carbacholinduced antinociception during both phases of formalin test and reduction in LH-induced analgesia during the late phase was more than that during the early phase. Furthermore, contribution of D2-like dopamine receptors to mediation of anti-hyperalgesic effect of carbachol was greater than that of D1-like dopamine receptors during the late phase. Conclusions: The findings suggest that LH-VTA-NAc circuit is contributed to the modulation of formalin-induced pain. These findings demonstrate that transmission at D1-and D2-like dopamine receptors mediates the LH-induced analgesia. Significance: Blockade of accumbal dopamine receptors attenuated analgesia induced by carbachol injection into the lateral hypothalamus during both phases of formalin test. Effect of blockade of D1-and D2-like dopamine receptors on reduction in antinociception was more during the late phase. Contribution of D2-like dopamine receptors to mediation of antinociception during the late phase was greater than the early phase.

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“…Naïve rats model acute nociception and rats with chronic constriction injury (CCI) model hyperalgesia seen in neuropathic pain (Bennett and Xie, 1988; Attal et al, 1990; Kim et al, 1997). We found that stimulating the LH with the cholinergic agonist carbachol produces antinociception in both naïve and CCI rats, although pain condition and sex differences occur (Holden et al, 2014). We have also shown that, in naïve females, antinociception from LH stimulation occurs in part from norepinephrine acting at α 2 -adrenoceptors in the spinal cord dorsal horn, but that concurrent pronociception also occurs from norepinephrine acting at α 1 -adrenoceptors (Holden and Naleway, 2001; Jeong and Holden, 2009).…”

Section: Introductionmentioning

confidence: 97%

“…The lateral hypothalamus (LH) plays an important role in descending modulation in acute nociception (Holden et al, 2001, 2009; Esmaeili et al, 2016), persistent inflammation (Jeong and Holden, 2009; Ezzatpanah et al, 2015; Jahangirvand etal., 2016; Yazdi et al, 2016), and hyperalgesia from nerve injury (Holden et al, 2014; Wardach et al, 2016). The LH modifies nociception in part through connections with the A7 catecholamine cell group, a group of spinally descending noradrenergic neurons, as shown by anatomical study (Clark and Proudfit, 1991) and behavioral studies (Yeomans et al, 1992; Yeomans and Proudfit, 1992; Holden and Proudfit, 1998; Holden et al, 1999; Nuseir and Proudfit, 2000).…”

Section: Introductionmentioning

confidence: 99%

Pain condition and sex differences in the descending noradrenergic system following lateral hypothalamic stimulation

et al. 2020

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Differences in carbachol dose, pain condition, and sex following lateral hypothalamic stimulation

Cited by 15 publications

References 92 publications

Lateral Hypothalamic Stimulation Reduces Hyperalgesia Through Spinally Descending Orexin-A Neurons in Neuropathic Pain

Lateral Hypothalamic Stimulation Reduces Hyperalgesia Through Spinally Descending Orexin-A Neurons in Neuropathic Pain

Nucleus accumbens dopamine receptors mediate hypothalamus‐induced antinociception in the rat formalin test

Pain condition and sex differences in the descending noradrenergic system following lateral hypothalamic stimulation

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