Differences in corpus callosum morphology between healthy adolescents and adolescents with migraine: a case control study

Abstract

Background/aim: This study objected to compare the measurements of corpus callosum substructures of adolescents with migraine and healthy adolescents. Materials and methods:In a case-control design, adolescents aged 12-18 years with the diagnosis of migraine and healthy control group had brain magnetic resonance imaging examination. The CC dimensions including anteroposterior length, truncus, genu and splenium widths of the case and control groups were measured and compared. Results:The sample consisted of 188 adolescents, 109 girls (58.0%) and 79 boys (42.0%). Of these 87 (46.3%) were in the migraine group and 101 (53.7%) were in the healthy control group. The mean genu and splenium width of the migraine group were significantly lower than the control group (p=0.024 and p=0.01 respectively). Conclusion:The results of this study firstly demonstrated that CC splenium and genu widths were smaller in adolescents with migraine when compared to healthy adolescents. Our findings may contribute to enlighten migraine pathophysiology.

Migrenli hastalarda başağrısı, korpus kallozum ve derin beyaz madde lezyonları arasındaki ilişki

“…According to the MIDAS scale, the measured values of the CC trunk were significantly lower in the moderate and severe disability groups. Akin et al 11 reportedthat the measured values of the CC splenium and genu were smaller in adolescents with migraines compared to healthy adolescents. Demir et al 30 reported a statistically significant reduction in the CC volume when migraine patients and control groups were compared.…”

“…There are very few studies on CC measurements in migraine patients. Although some authors noted the presence of a smaller CC in patients with migraine compared to controls, the role of the CC in the pathophysiology of migraine has not been fully understood 10,11 . A better understanding of the brain changes of patients with migraines will not only aid in diagnosis but may also help explain migraine pathophysiology, leading to the development of targeted anti-migraine therapies.…”