Differences in COVID-19 Outcomes Among Patients With Type 1 Diabetes: First vs Later Surges

Abstract

fter the World Health Organization declared the disease caused by the novel coronavirus SARS-CoV-2, COVID-19, a pandemic on March 11, 2020, the Centers for Disease Control and Prevention identified patients with diabetes as high risk for severe illness. [1][2][3][4][5][6][7] The case-fatality rate for COVID-19 has significantly improved over the past 2 years. Public health measures, less severe COVID-19 variants, increased access to testing, and new treatments for COVID-19 have contributed to improved outcomes.The T1D Exchange has previously published findings on COVID-19 outcomes for patients with type 1 diabetes (T1D) using data from the T1D COVID-19 Surveillance Registry. [8][9][10][11][12] Given improved outcomes in COVID-19 in the general population, we sought to determine if outcomes for cases of COVID-19 reported to this registry changed over time.

Diabetes Population Health Innovations in the Age of COVID-19: Insights From the T1D Exchange Quality Improvement Collaborative

“…The existing health collaborative served as a springboard for robust surveillance study, documenting numerous works on the effects of COVID-19. 3,4,[20][21][22][23][24][25][26][27][28] Other investigators also embraced the power of real-world surveillance and real-world data. 29,30 Big Data, Machine Learning, and Artificial Intelligence…”

Impact of SARS-CoV-2 infection on disease trajectory in youth with T1D: An EHR-based cohort study from the RECOVER program

“…We selected T1D since it is associated with an increased risk of severe disease in children with COVID-19 infection (3-5; 31) and also thought to be a feature of PASC itself (20; 21). We focused on T1D since it is more common in the pediatric age group than type 2 diabetes (32)(33)(34)(35). Using the NIH Researching COVID to Enhance Recovery (RECOVER) EHR database, we evaluated the impact of SARS-CoV-2 infection on T1D disease trajectory as measured by rates of hospital and emergency department utilization due to diabetes complications as well as changes in HbA1c trajectory, in youth with established type 1 diabetes.…”