Differences in cytocompatibility and hemocompatibility between carbon nanotubes and nitrogen-doped carbon nanotubes

Zhao, Mengli; Li, D.J.; Yuan, Li; Yue, Y.C.; Liu, H.; Sun, Xueliang

doi:10.1016/j.carbon.2011.03.037

Cited by 43 publications

(46 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Brought to you by | MIT Libraries Authenticated Download Date | 5/9/18 7:10 AM MWCNT [23]. The electrochemical data also indicated that CNx electrode with the lowest nitrogen content (1 atom %) showed the highest reversible capacity 270 mAh g -1 at the current density of 0.2 mA cm -2 and the highest value of exchange current density [54,56].…”

Section: Electrochemical Modificationmentioning

confidence: 72%

“…Copyright doping) to the p-type conduction (B substitution of boron in lattice) [21]. To solve the dispersion problem and to enhance the reactivity, the CNTs have been modified and functionalized for their application in electronics [22][23][24], clinical and biomedical [23], liquid-phase reactions [25], power sources filed [26][27][28] as nanoenergetic materials [29], and as gas sensors [30][31][32]. For the purpose of this review, we will also focus their representative/promising applications in the described fields covering from building materials to biological materials and from the electrical devices to the high nanoenergetic materials.…”

Section: Figure 2 (A)mentioning

confidence: 99%

See 1 more Smart Citation

Synthesis and electrochemical applications of nitrogen-doped carbon nanomaterials

Majeed¹,

Zhao²,

Zhang³

et al. 2013

Nanotechnology Reviews

View full text Add to dashboard Cite

Abstract:Nitrogen doping is an effective way to tailor the properties of the shaped carbon materials, including the nanotubes, nanocups, nanofibers, as well as the nanorods, and render their potential use for various applications. The common bonding configurations obtained on the N insertion is the pyridinic N and pyrrolic N, which impart the characteristic properties to these carbon materials. This review will focus on the nitrogen-doped carbon materials, the doping effect on the electrochemistry of the doped nanomaterials, and the various synthetic methods to introduce N into the carbon network. The potential applications of the N-doped materials are also reviewed on the basis of the experimental and theoretical studies in electrochemistry.

show abstract

Section: Electrochemical Modificationmentioning

confidence: 72%

Section: Figure 2 (A)mentioning

confidence: 99%

Synthesis and electrochemical applications of nitrogen-doped carbon nanomaterials

Majeed¹,

Zhao²,

Zhang³

et al. 2013

Nanotechnology Reviews

View full text Add to dashboard Cite

show abstract

“…1,2 However, the fibril structure of pristine CNTs has rather inaccessible hollow interiors and may cause severe inflammatory response and cytotoxic effects in biological systems. 3,4 Nitrogen-doped CNTs, on the other hand, have been found to possess higher biocompatibility than undoped multiwalled carbon nanotubes (MWCNTs) 5,6 and may have better drug delivery performance. Doping of nitrogen atoms into the nanotube graphitic lattices results in a compartmented hollow structure resembling stacked cups which can be separated out to obtain individual nitrogen-doped carbon nanotube cups (NCNCs) with typical length under 200 nm.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Functionalization of Nitrogen-doped Carbon Nanotube Cups with Gold Nanoparticles as Cork Stoppers

Zhao

Tang

Star

2013

JoVE

View full text Add to dashboard Cite

Nitrogen-doped carbon nanotubes consist of many cup-shaped graphitic compartments termed as nitrogen-doped carbon nanotube cups (NCNCs). These as-synthesized graphitic nanocups from chemical vapor deposition (CVD) method were stacked in a head-to-tail fashion held only through noncovalent interactions. Individual NCNCs can be isolated out of their stacking structure through a series of chemical and physical separation processes. First, as-synthesized NCNCs were oxidized in a mixture of strong acids to introduce oxygen-containing defects on the graphitic walls. The oxidized NCNCs were then processed using high-intensity probe-tip sonication which effectively separated the stacked NCNCs into individual graphitic nanocups. Owing to their abundant oxygen and nitrogen surface functionalities, the resulted individual NCNCs are highly hydrophilic and can be effectively functionalized with gold nanoparticles (GNPs), which preferentially fit in the opening of the cups as cork stoppers. These graphitic nanocups corked with GNPs may find promising applications as nanoscale containers and drug carriers. Video LinkThe video component of this article can be found at

show abstract

“…CNTs are tiny hollow cylinders, made from a single, double, or several layers of graphene that are concentrically arranged and capped by fullerene hemispheres. They have diameters ranging from 0.4 to 2 nm for single walled carbon nanotubes (SWCNTs) and from 2 to 200 nm for multiwall carbon nanotubes (MWCNTs), and lengths ranging from hundreds of nanometers to micrometers [1][2][3]. Since CNTs have an asbestos-like shape, research into their toxicity and potential risks to human health has been intensified [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…Chemical doping (carbon atoms substitution) with nitrogen of CNTs (CN x ) was suggested to have positive effects on mice survival [8] and showed an improvement in cell-adhesion strength, viability, and proliferation of mammalian cells [3,9], in contrast with the MWCNT. However, cytotoxic effects of CN x have also been reported, where long length CN x were more toxic than other functionalized CNTs [10].…”

Section: Introductionmentioning

confidence: 99%

Effects of Nitrogen‐Doped Multiwall Carbon Nanotubes on Murine Fibroblasts

Munguia-Lopez

Muñoz‐Sandoval

Ortiz‐Medina

et al. 2015

Journal of Nanomaterials

View full text Add to dashboard Cite

The effect of nitrogen-doped multiwall carbon nanotubes (CN x ) on the proliferation of NIH-3T3 murine fibroblasts is presented. CNTs were dispersed in distillated water and incubated with mammalian cells in order to evaluate their toxicity. Also, the influence of factors such as dosage (7 and 70 g/mL), exposure time (24 to 96 h), and the exposure route (before and after cell liftoff) on the cell proliferation was evaluated. When the CN x were simultaneously incubated with the cells, the control culture reached a maximum cell concentration of 1.3 × 10 5 ± 3.4 × 10 4 cells per well at 96 h, whereas cultures with 7 g/mL reached a concentration of 2.6 × 10 4 ± 5.3 × 10 3 cells. In the case of 70 g/mL of CN x most of the cells were dead. The CN x that were added 24 h after cell dissociation showed that live cells decreased, with a cell concentration of 9.6 × 10 4 ± 9 × 10 3 for 7 g/mL and 5.5 × 10 4 ± 9.5 × 10 3 for 70 g/mL, in contrast to control cultures with 1.1 × 10 6 ± 1.5 × 10 4 . The results showed that the CN x had cytotoxic effects depending on the concentration and exposure route.

show abstract

Differences in cytocompatibility and hemocompatibility between carbon nanotubes and nitrogen-doped carbon nanotubes

Cited by 43 publications

References 29 publications

Synthesis and electrochemical applications of nitrogen-doped carbon nanomaterials

Synthesis and electrochemical applications of nitrogen-doped carbon nanomaterials

Synthesis and Functionalization of Nitrogen-doped Carbon Nanotube Cups with Gold Nanoparticles as Cork Stoppers

Effects of Nitrogen‐Doped Multiwall Carbon Nanotubes on Murine Fibroblasts

Contact Info

Product

Resources

About