Differences in diagnosis, treatment, and survival rate of acute myeloid leukemia with or without disabilities: A national cohort study in the Republic of Korea

Kwon, Jihyun; Kim, So Young; Yeob, Kyoung Eun; Han, Hye Sook; Lee, Ki Hyeong; Shin, Dong Wook; Kim, Yeon‐Yong; Park, Jong Heon; Park, Jong Hyock; Kawachi, Ichiro

doi:10.1002/cam4.3179

Cited by 7 publications

(12 citation statements)

References 17 publications

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“…The prevalence of AML in Koreans increases noticeably at the age of 60, and the average onset age is known to be in the mid-60s. [6][7][8] However, since this patient is relatively young and a non-smoker, risk factor such as old age and smoking are unlikely to be the causes of this disease. In addition, all other well-known risk factors for AML, such as chemotherapy, radiation exposure, infection, hematopoietic disorder, genetic disorder, and family history of AML, are not applicable in this patient, and was excluded.…”

Section: Discussionmentioning

confidence: 94%

Acute myeloid leukemia in a farmer with long term exposure to pesticides in Korea

Jeon¹,

Ha²,

Kim³

et al. 2022

Medicine: Case Reports and Study Protocols

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Rationale: Pesticides are chemical substances used to kill harmful insects, small animals, wild plants, and other unwanted organisms. It has not been clearly demonstrated in myeloid malignancies, particularly acute myeloid leukemia.Patient concerns: A 46-year-old male farmer visited the hospital with chief complaints of multiple purpuric macules on the left upper chest to both leg areas. The patient had been farming lotus roots for 20 years and was exposed to a substantial amount of pesticide without proper personal protective equipment.Diagnoses: The patient was diagnosed with acute myeloid leukemia by bone marrow biopsy.Intervention: The patient received induction chemotherapy with idarubicin and cytarabine. He has undergone consolidation chemotherapy two more times.Outcomes: He had neutropenic fever as a complication after chemotherapy, but he is doing well with no other symptoms. There has been no abnormality in blood tests since the consolidation therapy, and it has been well maintained in remission. Conclusion:This case report suggests that acute myeloid leukemia is associated with occupational pesticide exposure, along with a review of the literature. The impact of occupational pesticide exposure on myeloid leukemia has not been clearly established, and large-scale studies on the relationship between pesticide use and cancer, including myeloid leukemia, should be conducted.

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Section: Discussionmentioning

confidence: 94%

Acute myeloid leukemia in a farmer with long term exposure to pesticides in Korea

Jeon¹,

Ha²,

Kim³

et al. 2022

Medicine: Case Reports and Study Protocols

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“…(41,44,49,63,67) In studies that examined survival in cancer patients with all types of disability, there seemed to be far worse outcomes for those with severe disabilities and with intellectual impairment, with a large portion of that disparity not justifiable on the basis of rational clinical decisions. (19,22,65) However, it had a high risk of bias since the incidence of disability in its retrospective cohort was inexplicably only half of the known national incidence, suggesting severe misclassification bias, and data about gender and degree of disability was missing.…”

Section: Outcome Resultsmentioning

confidence: 99%

“…physical/communication/mental/internal organ/others). (19,22,23,43,(61)(62)(63)(64)(65) Few studies differentiated by severity of impairment. (19,22,63,65,66)…”

Section: Types Of Disabilitiesmentioning

confidence: 99%

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Do people with disabilities experience disparities in cancer care? A systematic review

Tosetti

Kuper

2023

Preprint

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Background: Over 1.3 billion people, or 16% of the world's population, live with some form of disability. Recent studies have reported that patients with disabilities might not be receiving state-of-the-art treatment for cancer as their non-disabled peers; our objective was to systematically review this topic. Methods: A systematic review was undertaken to compare cancer outcomes and quality of cancer care between adults with and without disabilities (NIHR Prospero register ID number: CRD42022281506). A search of the literature was performed in July 2022 across five databases: EMBASE, Medline, Cochrane Library, Web of Science and CINAHL databases. Peer-reviewed quantitative research articles, published in English from 2000 to 2022, with interventional or observational study designs, comparing cancer outcomes between a sample of patients with disabilities and a sample without disabilities were included. Studies were evaluated for risk of bias based on a set of criteria according to the SIGN 50 guidelines. A narrative synthesis was conducted according to the Cochrane SWiM guidelines, with tables summarizing study characteristics and outcomes. This research received no external funding. Results: Thirty-one studies were included in the systematic review. Compared to people without disabilities, people with disabilities had worse cancer outcomes, in terms of poorer survival and higher overall and cancer-specific mortality. There was also evidence that people with disabilities received poorer quality cancer care, including: lower access to state-of-the-art care or curative-intent therapies, treatment delays, undertreatment or excessively invasive treatment, worse access to in-hospital services, less specialist healthcare utilization, less access to pain medications and inadequate end-of-life quality of care. Discussion: Limitations of this work include results from high-income countries only, exclusion of qualitative research, no meta-analysis and high risk of bias in 15% of included studies. In spite of these limitations, our results show that people with disabilities often experience severe disparities in cancer care: barriers at different levels must be eliminated to ensure that they receive equitable treatment.

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“…In case 1, the patient was still alive after 78 months. The survival of these patients was not as poor as expected for patients with t(3;21), with a reported median OS for AML and MDS in Korea of 15.7 and 17.7 months, respectively [ 7 , 8 ].…”

mentioning

confidence: 97%

Clinical and Genomic Profiles of Korean Patients with MECOM Rearrangement and the t(3;21)(q26.2;q22.1) Translocation

et al. 2022

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The translocation (3;21)(q26.2;q22.1) is a unique cytogenetic aberration that characterizes acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) in patients with AML and myelodysplastic syndrome (MDS) or a therapy-related myeloid neoplasm. Using multigene target sequencing and FISH, we investigated the clinical and genomic profiles of patients with t(3;21) over the past 10 years. The frequency of t(3;21) among myeloid malignancies was very low (0.2%). Half of the patients had a history of cancer treatment and the remaining patients had de novo MDS. Twenty-one somatic variants were detected in patients with t(3;21), including in CBL , GATA2 , and SF3B1 . Recurrent variants in RUNX1 (c.1184A>C, p.Glu395Ala) at the same site were detected in two patients. None of the patients with t(3;21) harbored germline predisposition mutations for myeloid neoplasms. MECOM rearrangement was detected at a higher rate using FISH than using G-banding, suggesting that FISH is preferable for monitoring. Although survival of patients with t(3;21) is reportedly poor, the survival of patients with t(3;21) in this study was not poor when compared with that of other AML patients in Korea.

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Differences in diagnosis, treatment, and survival rate of acute myeloid leukemia with or without disabilities: A national cohort study in the Republic of Korea

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 7 publications

References 17 publications

Acute myeloid leukemia in a farmer with long term exposure to pesticides in Korea

Acute myeloid leukemia in a farmer with long term exposure to pesticides in Korea

Do people with disabilities experience disparities in cancer care? A systematic review

Clinical and Genomic Profiles of Korean Patients with MECOM Rearrangement and the t(3;21)(q26.2;q22.1) Translocation

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