Differences in early and late pattern-onset visual-evoked potentials between self- reported migraineurs and controls

Fong, Chun Yuen; Law, Wai Him Crystal; Braithwaite, Jason J.; Mazaheri, Ali

doi:10.1016/j.nicl.2019.102122

Cited by 25 publications

(27 citation statements)

References 69 publications

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“…For the VEP N2 component, amplitude and latency did not differ between FHM1 and WT mice. In migraine patients, using pattern‐VEP stimulation, N2 amplitude was reported to be enhanced (Fong et al., 2020) and latency prolonged (Oelkers et al., 1999), which may explain aversive responses of migraineurs to specific patterns and frequencies of light (Fong et al., 2020; Oelkers et al., 1999). Since early and late N2 components are proposed to reflect distinct visual system responsivity to contour and luminescence (Diener et al., 1989; Fong et al., 2020; Oelkers et al., 1999), respectively, pattern stimulation may reveal whether similar N2 changes exist for FHM1 mice.…”

Section: Discussionmentioning

confidence: 99%

Responsivity to light in familial hemiplegic migraine type 1 mutant mice reveals frequency‐dependent enhancement of visual network excitability

Perenboom

Schenke

Ferrari

et al. 2020

Eur J of Neuroscience

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Migraine patients often report (inter)ictal hypersensitivity to light, but the underlying mechanisms remain an enigma. Both hypo‐ and hyperresponsivity of the visual network have been reported, which may reflect either intra‐individual dynamics of the network or large inter‐individual variation in the measurement of human visual evoked potential data. Therefore, we studied visual system responsivity in freely behaving mice using combined epidural electroencephalography and intracortical multi‐unit activity to reduce variation in recordings and gain insight into visual cortex dynamics. For better clinical translation, we investigated transgenic mice that carry the human pathogenic R192Q missense mutation in the α1A subunit of voltage‐gated CaV2.1 Ca2+ channels leading to enhanced neurotransmission and familial hemiplegic migraine type 1 in patients. Visual evoked potentials were studied in response to visual stimulation paradigms with flashes of light. Following intensity‐dependent visual stimulation, FHM1 mutant mice displayed faster visual evoked potential responses, with lower initial amplitude, followed by less pronounced neuronal suppression compared to wild‐type mice. Similar to what was reported for migraine patients, frequency‐dependent stimulation in mutant mice revealed enhanced photic drive in the EEG beta‐gamma band. The frequency‐dependent increases in visual network responses in mutant mice may reflect the context‐dependent enhancement of visual cortex excitability, which could contribute to our understanding of sensory hypersensitivity in migraine.

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Section: Discussionmentioning

confidence: 99%

Responsivity to light in familial hemiplegic migraine type 1 mutant mice reveals frequency‐dependent enhancement of visual network excitability

Perenboom

Schenke

Ferrari

et al. 2020

Eur J of Neuroscience

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“…A recent study used gratings instead of checkerboard pattern and found that migraine patients had increased N2 amplitude in high frequency gratings compared to controls and suggested these data are in line with cortical hyperexcitability. They also showed higher amplitude in MWO patients than MA patients [31,29]. Conversely there are studies arguing against magnocellular pathway involvement dominancy.…”

Section: Discussionmentioning

confidence: 92%

Evaluation of migraine without aura patients by visual evoked potentials with different spatial frequencies

Ataç

Tuna

2020

Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi

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Çalışmamızın amacı, International Society for Clinical Electrophysiology of Vision (ISCEV) standartlarına göre, aurasız migren hastalarında, iki farklı kontrol boyutu (15 've 62') ile kaydedilen tersine çevrilmiş görsel uyarılmış potansiyellerindeki (PVEP'ler) değişiklikleri interiktal dönemde incelemektir. Gereç ve Yötemler: Hastaların demografik verileri; hastalık süresi, baş ağrısı özellikleri, bir aydaki atak sayısı, ortalama atak süresi, baş ağrısına eşlik eden şikayetler, baş ağrısının ortalama şiddeti gibi hastaların baş ağrısı günlüklerinden görsel analog ölçeğe göre belgelendi. Aurası olmayan yirmi migren hastası ve 14 sağlıklı gönüllü, iki farklı kontrol boyutuyla (15 've 62') kaydedilen PVEP'ler ile incelendi. Stimülasyon sekansları hem dama tahtasının kontrol boyutu hem de stimülasyon tarafı (sağ-15 ', sağ-62', sol-15 ', sol-62') için randomize edildi. N75, P100 gecikmesi ve N75-P100'ün tepeden tepeye genliği analiz edildi. Bulgular: Her iki kontrol boyutu için PVEP sonuçlarının latans ve amplitüdleri açısından sağlıklı kişiler ile aurasız migren hastaları arasında istatistiksel olarak fark yoktu (p> 0,05). Sonuç: Aurasız migren hastalarında, farklı spatyal frekanslara sahip PVEP'ler ile magnoselüler yol disfonksiyonunu tespit etmedik. Daha geniş hasta grupları ve PVEP'leri psikofiziksel testlerle birleştiren çalışmalara ihtiyaç vardır.

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“…More recently, Fong et al [ 10 ] used striped patterns of specific spatial frequencies (0.5, 3, and 13 cycles-per-degree) in MWA and MWoA subjects and healthy control participants. They found that people with migraine had a significantly increased N2 amplitude for stimuli with 13 cpd gratings and proposed that this is in support of the cortical hyperexcitation hypothesis in migraine.…”

Section: The Excitable Migraine Brain: With Aura or Without Aura That Is The Questionmentioning

confidence: 99%

Visual Perception in Migraine: A Narrative Review

Hadjikhani

Vincent

2021

Vision

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Migraine, the most frequent neurological ailment, affects visual processing during and between attacks. Most visual disturbances associated with migraine can be explained by increased neural hyperexcitability, as suggested by clinical, physiological and neuroimaging evidence. Here, we review how simple (e.g., patterns, color) visual functions can be affected in patients with migraine, describe the different complex manifestations of the so-called Alice in Wonderland Syndrome, and discuss how visual stimuli can trigger migraine attacks. We also reinforce the importance of a thorough, proactive examination of visual function in people with migraine.

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Differences in early and late pattern-onset visual-evoked potentials between self- reported migraineurs and controls

Cited by 25 publications

References 69 publications

Responsivity to light in familial hemiplegic migraine type 1 mutant mice reveals frequency‐dependent enhancement of visual network excitability

Responsivity to light in familial hemiplegic migraine type 1 mutant mice reveals frequency‐dependent enhancement of visual network excitability

Evaluation of migraine without aura patients by visual evoked potentials with different spatial frequencies

Visual Perception in Migraine: A Narrative Review

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