Differences in eosinophil molecular profiles between children and adults with eosinophilic esophagitis

Wennerås, Christine; Käppi, Timo; Bergquist, Henrik; Bove, Mogens; Arkel, Rikard; Saalman, Robert; Wennerås, Christine

doi:10.1111/all.13140

Cited by 22 publications

(24 citation statements)

References 37 publications

(84 reference statements)

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“…22,23 Analysis of protein expression patterns in gut biopsy samples from patients with celiac disease found a positive correlation between CLC/Gal-10 levels and tissue damage, and a recent study showed that higher levels of CLC/Gal-10 mRNA distinguished children with eosinophilic esophagitis from control children. 24,25 A recent report by Persson et al showed that human CLCs administered directly into mouse airways act as a type 2 adjuvant, mimicking many features of human asthma; the effects were readily reversible by CLC-dissolving anti-Gal-10 mAbs, suggesting a possible therapeutic approach. 26 Intriguingly, in addition to the considerable amounts present in eosinophils and basophils, CLC/Gal-10 is also expressed in human CD4 1 CD25 1 regulatory T cells, where it is necessary for the maintenance of immunosuppressive functions.…”

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confidence: 99%

Charcot-Leyden crystal protein/galectin-10 interacts with cationic ribonucleases and is required for eosinophil granulogenesis

Grozdanović

Doyle

Liu

et al. 2020

Journal of Allergy and Clinical Immunology

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Charcot-Leyden Crystal Protein/Galectin-10 Interacts with Cationic Ribonucleases and is Required for Eosinophil Granulogenesis EDN CLC/Gal-10 CD63 CLC/Gal-10 CLC/Gal-10 colocalizes with the secondary granule's tetraspanin (CD63) and with EDN (RNase2) during eosinophil degranulation CD34 IL-5Rα IL-5Rα Siglec-8 CCR3 CLC/Gal-10 Secondary granules EDN (RNase2), ECP (RNase3), MBP-1, EPX, cytokines, etc.

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mentioning

confidence: 99%

Charcot-Leyden crystal protein/galectin-10 interacts with cationic ribonucleases and is required for eosinophil granulogenesis

Grozdanović

Doyle

Liu

et al. 2020

Journal of Allergy and Clinical Immunology

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“…However, it is important to note that not all eosinophils are the same, even within the same disease and organ system. Eosinophils differ in their molecular pattern as observed by Lingblom et al when investigating differences in children and adults with eosinophilic esophagitis ( 123 ). Moreover, investigations in healthy individuals revealed age-dependent differences in levels of eosinophil markers.…”

Section: Known Mechanism Of Eosinophils With Potential Roles In Bp (Hmentioning

confidence: 85%

“…For instance, levels of CD44 increased with age, while levels of CD54, prostaglandin DP2 receptor (CRTH2), and galectin-10 decreased with age. In addition, they demonstrated that young healthy children express highest levels of galectin-10, CRTH2, and CD54 and that these diminish with age ( 123 ). Similarly, the gastrointestinal system hosts substantial number of eosinophils exhibiting differences to eosinophils in the lungs or blood.…”

Section: Known Mechanism Of Eosinophils With Potential Roles In Bp (Hmentioning

confidence: 99%

The Role of Eosinophils in Bullous Pemphigoid: A Developing Model of Eosinophil Pathogenicity in Mucocutaneous Disease

et al. 2018

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Bullous pemphigoid (BP) is an autoimmune blistering disease which carries a significant mortality and morbidity. While historically BP has been characterized as an IgG driven disease mediated by anti-BP180 and BP230 IgG autoantibodies, developments in recent years have further elucidated the role of eosinophils and IgE autoantibodies. In fact, eosinophil infiltration and eosinophilic spongiosis are prominent features in BP. Several observations support a pathogenic role of eosinophils in BP: IL-5, eotaxin, and eosinophil-colony stimulating factor are present in blister fluid; eosinophils line the dermo-epidermal junction (DEJ) in the presence of BP serum, metalloprotease-9 is released by eosinophils at the site of blisters; eosinophil degranulation proteins are found on the affected basement membrane zone as well as in serum corresponding with clinical disease; eosinophil extracellular DNA traps directed against the basement membrane zone are present, IL-5 activated eosinophils cause separation of the DEJ in the presence of BP serum; and eosinophils are the necessary cell required to drive anti-BP180 IgE mediated skin blistering. Still, it is likely that eosinophils contribute to the pathogenesis of BP in numerous other ways that have yet to be explored based on the known biology of eosinophils. We herein will review the role of eosinophils in BP and provide a framework for understanding eosinophil pathogenic mechanisms in mucocutaneous disease.

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“…The use of advanced techniques (Roth et al ; Wilkerson et al ) to identify surface and secreted proteins in health and disease states in the horse would firstly improve the clinical utility of eosinophil counts, and secondly facilitate research as described below. What is the effect of age on equine eosinophil biology? Age‐related variation in eosinophil function is recognised in human subjects (Mathur et al ; Lingblom et al ). Age‐associated variation in eosinophils is evident in normal horses, response to pathogens and EADs, but molecular mechanisms are unknown.…”

Section: Discussionmentioning

confidence: 99%

Eosinophils of the horse: Part II: Eosinophils in clinical diseases

Brosnahan

2020

Equine Veterinary Education

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Interpretation of eosinophilia in body fluids or tissues is often not straightforward. Eosinophil counts vary among clinically healthy individuals, and considerable overlap can occur between normal and affected animals in conditions such as allergic airway disease. Parasite exposure is a confounding factor when counts are increased, and in cases where very high counts and dramatic clinical signs make another disease process obvious, the underlying pathology may be uncertain and treatment difficult. Eosinophils are a component of the immune response in many diseases of the horse, but their specific role is often unknown and likely multifactorial. In helminth infections, eosinophils are assumed to be part of the normal host response to a pathogen, whereas in multisystemic eosinophilic epitheliotropic disease (MEED), the predominance of eosinophils likely represents a wildly dysregulated response, or an abnormal response altogether. This distinction is still not clear for other diseases. Understanding the pathways involved in recruitment, activation or suppression of eosinophils is required for more accurate diagnostics, effective therapeutics, and successful strategies for prevention of eosinophil associated diseases. Eosinophils of the horse: Part II reviews published observations on the eosinophil in clinical diseases of the horse. The behaviour of eosinophils in three common and relatively wellstudied conditions is presented first, including gastrointestinal helminth infections, non-infectious respiratory disease, and insect bite hypersensitivity. The less common eosinophilassociated diseases such as eosinophilic disease confined to the intestine (EDCI) and MEED are considered, followed by a brief summary of the eosinophil in phycomycosis and neoplasia. In conclusion, a panoramic view of the equine eosinophil as presented in Parts I and II is placed in the larger context of current eosinophil research, and areas of study are identified that may improve our understanding of eosinophil biology in equine health and clinical disease. Gastrointestinal parasites of the horse Gastrointestinal helminths are a widespread and well-studied problem in the horse. Clinical disease is associated historically with migratory large strongyles (Strongylus vulgaris, S. edentatus, S. equinus), small strongyles (cyathostomes), tapeworms (Anoplocephala perfoliata) and, in foals, ascarids (Parascarus equorum). Early studies sought to define parasite life cycles, but post-infection necropsies also described the eosinophilic response (Duncan and Pirie 1975). Host immunity and anthelmintics were the focus of later works (Bailey et al. 1989; Steuer et al. 2018). Variables exist across studies, including dosing variations, natural versus experimental

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Differences in eosinophil molecular profiles between children and adults with eosinophilic esophagitis

Abstract: Children with EoE can be distinguished from healthy children based on the molecular patterns of their blood eosinophils. Age-related physiologic differences in eosinophil molecular patterns may partly explain the different blood eosinophil phenotypes in children vs adults with EoE.

Cited by 22 publications

References 37 publications

Charcot-Leyden crystal protein/galectin-10 interacts with cationic ribonucleases and is required for eosinophil granulogenesis

Charcot-Leyden crystal protein/galectin-10 interacts with cationic ribonucleases and is required for eosinophil granulogenesis

The Role of Eosinophils in Bullous Pemphigoid: A Developing Model of Eosinophil Pathogenicity in Mucocutaneous Disease

Eosinophils of the horse: Part II: Eosinophils in clinical diseases

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