Differences in Expression of EGFR, Ki67 and p-EPK in Oral Cavity Squamous Cell Carcinoma

Bu, Jing-qiu; Bu, Xi; Chen, Peng; Liu, Bing; Chen, Fei

doi:10.4314/tjpr.v14i12.9

Cited by 3 publications

(1 citation statement)

References 8 publications

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“…A relevant proportion of HPV-positive OPC patients may enjoy a favorable prognosis due to molecular determinants related to good response to radiotherapy and radiochemotherapy, such as low EGFR expression [22][23][24]. It has been shown, in fact, that EGFR is expressed at lower levels in HPV-positive oropharyngeal and oral cancer patients compared to the HPV-negative ones [22,[24][25][26], and this has a favorable impact on prognosis after radio-or radiochemotherapy treatment [22,23]. Furthermore, it is known that the expression of the HER family of proteins may explain the attenuation of the antiproliferative effects of CDDP [27].…”

Section: Discussionmentioning

confidence: 99%

Subgroup Analysis According to Human Papillomavirus Status and Tumor Site of a Randomized Phase II Trial Comparing Cetuximab and Cisplatin Combined With Radiation Therapy for Locally Advanced Head and Neck Cancer

Buglione¹,

Maddalo²,

Corvò

et al. 2017

International Journal of Radiation Oncology*Biology*Physics

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Section: Discussionmentioning

confidence: 99%

Subgroup Analysis According to Human Papillomavirus Status and Tumor Site of a Randomized Phase II Trial Comparing Cetuximab and Cisplatin Combined With Radiation Therapy for Locally Advanced Head and Neck Cancer

Buglione¹,

Maddalo²,

Corvò

et al. 2017

International Journal of Radiation Oncology*Biology*Physics

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Molecular and Immunohistochemical Cognizance of HPV16 in Oral Leukoplakia, Oral Squamous Cell Carcinoma and Oropharyngeal Squamous Cell Carcinoma

Sivakumar

Narwal

Kamboj

et al. 2021

Head and Neck Pathol

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Correlation between Ki-67 labeling index and mitotic index in Head and neck squamous cell carcinoma

Deepa,

Balakrishnan

2024

Indian Journal of Pathology and Microbiology

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Background: Proliferative activity of any tissue or neoplasm can be determined by its growth rate by mitotic count or by using antibodies directed against specific antigens like Ki-67. The usefulness of Ki-67 in head and neck cancers has been debated for the past 20 years; however, no study has definitively resolved this controversy. Aim: Assess the correlation between Ki-67 expression and mitotic index in head and neck squamous cell carcinoma. Materials and Methods: This cross-sectional study was performed in 66 histologically proven cases of Head and Neck Squamous cell carcinoma (SCC) received in a histopathology laboratory and satisfied the specified criteria. Tumor was graded. Mitotic and Ki67 labeling index was calculated. Statistical analysis was performed using appropriate techniques to determine the correlation coefficient. Results: A statistically significant difference in the Ki67 labeling index (LI) between the grades of the tumor proper was noted (P = 0.040). An increase in the mean mitotic index with histological grade was noted, which was statistically significant in the proliferating margin (P = 0.037). A statistically significant positive correlation was noted between Ki67 LI and mitotic index in tumor proper (r = 0.263, P = 0.033) and proliferative margin (r = 0.364, P = 0.003). Conclusion: Mitotic index, a rapid and affordable tool for assessing cellular proliferation, becomes more relevant and practically effective when used in conjunction with Ki-67. Combined analysis of the two indices can be useful in the early diagnosis of possibly malignant lesions and in predicting tumor behavior.

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Differences in Expression of EGFR, Ki67 and p-EPK in Oral Cavity Squamous Cell Carcinoma

Cited by 3 publications

References 8 publications

Subgroup Analysis According to Human Papillomavirus Status and Tumor Site of a Randomized Phase II Trial Comparing Cetuximab and Cisplatin Combined With Radiation Therapy for Locally Advanced Head and Neck Cancer

Subgroup Analysis According to Human Papillomavirus Status and Tumor Site of a Randomized Phase II Trial Comparing Cetuximab and Cisplatin Combined With Radiation Therapy for Locally Advanced Head and Neck Cancer

Molecular and Immunohistochemical Cognizance of HPV16 in Oral Leukoplakia, Oral Squamous Cell Carcinoma and Oropharyngeal Squamous Cell Carcinoma

Correlation between Ki-67 labeling index and mitotic index in Head and neck squamous cell carcinoma

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