Differences in food intake and genetic variability in taste receptors between Czech pregnant women with and without gestational diabetes mellitus

Bartáková, Vendula; Chalásová, Katarína; Zlámal, Filip; Bělobrádková, Jana; Kaňková, Kateřina

doi:10.1007/s00394-016-1334-6

Cited by 12 publications

(16 citation statements)

References 40 publications

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“…There is evidence that polymorphisms of BTR genes that impair the sensitivity to bitterness may be associated with changes in food intake and dysregulation of blood glucose. For example, women with gestational diabetes mellitus exhibited a lower T2R9 gene (rs3741845) frequency, and consumed more meat, dairy and sweet beverages compared to pregnant women without gestational diabetes mellitus ( 79 ). Similarly, dysfunction of T2R9 due to a single nucleotide polymorphism is associated with higher blood glucose and insulin responses to an oral glucose tolerance test in Amish individuals with and without type 2 diabetes ( 38 ).…”

Section: Clinical Implications Of Targeting Intestinal Btrsmentioning

confidence: 99%

Role of Intestinal Bitter Sensing in Enteroendocrine Hormone Secretion and Metabolic Control

et al. 2018

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The gastrointestinal tract stores ingested nutrients in the stomach which are then delivered to the small intestine at a controlled rate to optimize their digestion and absorption. The interaction of nutrients with the small and large intestine generates feedback that slows gastric emptying, induces satiation, and reduces postprandial glycemic excursions. The mechanisms underlying these nutrient-gut interactions are complex; it has only recently been appreciated that the gut has the capacity to detect intraluminal contents in much the same way as the tongue, via activation of specific G-protein-coupled receptors, and that ensuing signaling mechanisms modulate the release of an array of gut hormones that influence gastrointestinal motility, appetite and glycemia. Interestingly, evidence from preclinical models supports a functional link between intestinal bitter taste receptor (BTRs) and gastrointestinal hormone secretion, and the outcomes of recent studies indicate that stimulation of intestinal BTRs may be used to modulate gastrointestinal function, to diminish energy intake and limit postprandial blood glucose excursions in humans. This review summarizes current evidence about the expression and function of intestinal BTRs in relation to enteroendocrine hormone release and discusses the clinical implications of this pathway for the management of obesity and type 2 diabetes.

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Section: Clinical Implications Of Targeting Intestinal Btrsmentioning

confidence: 99%

Role of Intestinal Bitter Sensing in Enteroendocrine Hormone Secretion and Metabolic Control

et al. 2018

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“… vitamin and mineral pregnancy dietary intake Mean vitamin C intake was higher in controls than among cases ( p -value: 0.04). Mean calcium intake was higher in controls than among cases ( p -value: 0.01) Bartáková V, et al 2018 [ 43 ] Czech Republic - Europe n:363 cases:293 controls:70 case-control women aged 29–36 years who visited the Diabetes Centre of the University Hospital Brno. Gestational age between 24 and 30 weeks.…”

Section: Resultsmentioning

confidence: 99%

“…Three case-control studies, six cohorts and one cross-sectional study found an association between food or meals and the risk of developing GDM. The case-control studies evaluated adherence to dietary acid load (calculated using several nutrient intakes such as phosphorus, protein, calcium, magnesium and potassium) and the mediterranean diet (adherence to vegetables, fruits, legumes, cereals and bread, pasta, rice; fish and seafood; meat, poultry; dairy products; alcohol and ratio MUFAs/SFAs), food consumption and the asociation with GDM risk [ 30 , 43 , 60 ]. Women with higher scores of dietary acid load and a low mediterranean diet score were more likely to have GDM during pregnancy (OR = 9,27; 95% CI: 4.00–21.46) [ 30 , 56 ] .…”

Section: Resultsmentioning

confidence: 99%

“…Also, women with GDM exhibited significantly more frequent poultry, pork and smoked meat, dairy products and sweet beverages consumption. Women with GDM consumed less fresh vegetables compared to controls [ 43 ]. Another cohort study shows a positive association between higher quantities of grape, melon, and fruit juice and GDM, and a negative association between higher quantities of apple, orange and potatoes ( p < 0,05) [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

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Maternal dietary components in the development of gestational diabetes mellitus: a systematic review of observational studies to timely promotion of health

Lambert

Muñoz

Gil

et al. 2023

Nutr J

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Background There is ample evidence that considers diet as an important factor in the prevention of gestational diabetes mellitus (GDM). The aim of this review is to synthesise the existing evidence on the relationship between GDM and maternal dietary components. Methods We performed a systematic bibliographic search in Medline, Latin American and Caribbean Health Sciences Literature (Lilacs) and the Latin American Nutrition Archive (ALAN) of regional and local literature, limiting the searches to observational studies published between 2016 and 2022. Search terms related to nutrients, foods, dietary patterns and the relationship to GDM risk were used. The review included 44 articles, 12 of which were from America. The articles considered different topics about maternal dietary components as follows: 14 are about nutrient intake, 8 about food intake, 4 combined nutrient and food analysis and 18 about dietary patterns. Results Iron, processed meat and a low carbohydrate diet were positively associated with GDM. Antioxidant nutrients, folic acid, fruits, vegetables, legumes and eggs were negatively associated with GDM. Generally, western dietary patterns increase GDM risk, and prudent dietary patterns or plant-based diets decrease the risk. Conclusions Diet is considered one of the causes of GDM. However, there is no homogeneity in how people eat nor in how researchers assess diet in different contextual conditions of the world.

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“…Gestational diabetes mellitus (GDM) is often defined as a disturbance in glucose tolerance first detected during pregnancy. [1][2][3][4][5] The prevalence of GDM has increased steadily, with 14% of pregnancies in USA, 5.7% of pregnancies in Australia, and 5-10% of pregnancies in Asian countries presenting with GDM. In Iran, the prevalence of GDM has been estimated at 3.4% of all annual pregnancies.…”

Section: Introductionmentioning

confidence: 99%

Association of a plant‐based dietary pattern in relation to gestational diabetes mellitus

Zamani

Milajerdi

Tehrani

et al. 2019

Nutrition & Dietetics

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Aim The prevalence of gestational diabetes mellitus (GDM), which has adverse effects on mothers and their offspring, is increasing worldwide. The role of a plant‐based dietary pattern as a determinant of GDM is not well understood. Therefore, we examined the association between plant‐based dietary patterns and the risk of GDM. Methods We enrolled 460 pregnant women in this case–control study, of them 200 were cases and 260 were controls. Dietary intake of participants was evaluated using three 24‐hour dietary records. Adherence to the plant‐based dietary patterns was scored using three indices of the overall plant‐based dietary index (PDI), healthy plant‐based diet (hPDI) and unhealthy plant‐based diet index (uPDI). The risk of GDM was compared across tertiles of PDI, hPDI and uPDI. Results After multivariable adjustment, we demonstrated that the high PDI score was inversely associated with risk of GDM (OR = 0.47; 95% CI: 0.28–0.78, P = 0.004), but there was no significant association between hPDI (OR = 1.03; 95% CI: 0.64–1.65, P = 0.884) or uPDI (OR = 1.65; 95% CI: 0.98–2.78, P = 0.06) and GDM risk. Conclusions We found that following an overall plant‐based diet was associated with lower risk of GDM. Future studies are warranted with longitudinal designs to confirm these findings.

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Differences in food intake and genetic variability in taste receptors between Czech pregnant women with and without gestational diabetes mellitus

Abstract: Our study showed differences in dietary intake of selected food items between healthy pregnant women and those with GDM and genetic association of bitter taste receptor allele with GDM.

Cited by 12 publications

References 40 publications

Role of Intestinal Bitter Sensing in Enteroendocrine Hormone Secretion and Metabolic Control

Role of Intestinal Bitter Sensing in Enteroendocrine Hormone Secretion and Metabolic Control

Maternal dietary components in the development of gestational diabetes mellitus: a systematic review of observational studies to timely promotion of health

Association of a plant‐based dietary pattern in relation to gestational diabetes mellitus

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