Differences in Free Estradiol and Sex Hormone-Binding Globulin in Women with and without Premenstrual Dysphoric Disorder

Thys-Jacobs, Susan; McMahon, Don; Bilezikian, John P.

doi:10.1210/jc.2007-1726

Cited by 33 publications

(25 citation statements)

References 32 publications

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“…This latter finding is generally consistent with previous literature indicating that ovarian hormone levels, and those of many of their metabolites, do not differ in women with PMDD compared to healthy controls: Both lower (Thys-Jacobs et al 2008) and higher (Wang et al 1996) estradiol levels have been observed in women with menstrual-related mood disorders. Lower levels of progesterone have also been reported in women with PMS (Wang et al 1996), a finding not replicated by several previous and subsequent studies (Backstrom et al 1983; Eriksson et al 1992; Facchinetti et al 1993; Rubinow et al 1988; Thys-Jacobs et al 2008; Rapkin et al 1997). Different (Facchinetti et al 1993) and similar (Reame et al 1992) patterns of luteinizing hormone release have been reported in women with PMS compared to controls.…”

Section: Discussionsupporting

confidence: 92%

Emotion regulation in women with premenstrual dysphoric disorder

Petersen

London

Liang

et al. 2016

Arch Womens Ment Health

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Purpose Premenstrual dysphoric disorder (PMDD) is a psychiatric disorder that causes serious impairments in the functioning and quality of life of affected women. Until recently, research efforts were somewhat hampered by the lack of formal diagnostic criteria, which have now been codified as a category in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Better characterization of deficits in socioemotional functioning caused by PMDD may aid in improving treatment efforts. Methods In this investigation, prospective symptom ratings, based on DSM-5 criteria, were used to measure PMDD symptoms in 36 women (18 with PMDD, 18 healthy controls). Two self-report inventories, the Emotion Regulation Questionnaire and the Difficulties in Emotion Regulation Scale, were used to measure ability to regulate emotions, and socioemotional functioning was measured by inventories of social connectedness, perceived stress, and affect. Potential relationships between ability to regulate emotion and PMDD symptom severity, as well as other measures of socioemotional functioning and affective state were tested. Results Women with PMDD reported significantly more behavioral impulsivity, and greater difficulties in regulating emotion and in socioemotional functioning. Conclusions Cognitive or behavioral strategies to improve these problems may benefit women with PMDD and help to alleviate distress caused by this disorder.

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Section: Discussionsupporting

confidence: 92%

Emotion regulation in women with premenstrual dysphoric disorder

Petersen

London

Liang

et al. 2016

Arch Womens Ment Health

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“…Undiagnosed polycystic ovary syndrome may have potentially affected the findings but this was unlikely given low serum T. We did exclude participants using hormonal contraceptives as those could raise SHBG. It is possible that analysis by exercise was affected by menstrual cycle phase, since SHBG rises in the luteal phase [Thys-Jacobs et al 2008] and more women in the exercise group were in the luteal phase. However, we would then expect to see significant differences by exercise group, which was not the case.…”

Section: Discussionmentioning

confidence: 99%

The impact of supervised weight loss and intentional weight regain on sex hormone binding globulin and testosterone in premenopausal women

Aubuchon

Liu

Petroski

et al. 2016

Systems Biology in Reproductive Medicine

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What is the impact of intentional weight loss and regain on serum androgens in women? We conducted an ancillary analysis of prospectively collected samples from a randomized controlled trial. The trial involved supervised 10% weight loss (8.5 kg on average) with diet and exercise over 4–6 months followed by supervised intentional regain of 50% of the lost weight (4.6 kg on average) over 4–6 months. Participants were randomized prior to the partial weight regain component to either continuation or cessation of endurance exercise. Analytic sample included 30 obese premenopausal women (mean age of 40 ± 5.9 years, mean baseline body mass index (BMI) of 32.9 ± 4.2 kg/m2) with metabolic syndrome. We evaluated sex hormone binding globulin (SHBG), total testosterone (T), free androgen index (FAI), and high molecular weight adiponectin (HMWAdp). Insulin, homeostasis model assessment (HOMA), and quantitative insulin sensitivity check index (QUICKI), and visceral adipose tissue (VAT) measured in the original trial were reanalyzed for the current analytic sample. Insulin, HOMA, and QUICKI improved with weight loss and were maintained despite weight regain. Log-transformed SHBG significantly increased from baseline to weight loss, and then significantly decreased with weight regain. LogFAI and logVAT decreased similarly and increased with weight loss followed by weight regain. No changes were found in logT and LogHMWAdp. There was no significant difference in any tested parameters by exercise between the groups. SHBG showed prominent sensitivity to body mass fluctuations, as reduction with controlled intentional weight regain showed an inverse relationship to VAT and occurred despite stable HMWAdp and sustained improvements with insulin resistance. FAI showed opposite changes to SHBG, while T did not change significantly with weight. Continued exercise during weight regain did not appear to impact these findings.

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“…Although the menstrual cycle hormonal profiles of women with PMS showed that the pregnanediol peak occurred significantly later in PMS patients than in asymptomatic females [4], the results of Salonia et al. indicate that sexual functions do not depend on hormonal changes during the cycle [31].…”

Section: Introductionmentioning

confidence: 94%

Sexual Satisfaction in Females with Premenstrual Symptoms

Nowosielski

Drosdzol

Skrzypulec

et al. 2010

The Journal of Sexual Medicine

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Introduction The impact of premenstrual symptoms, such as the premenstrual syndrome (PMS) and the premenstrual dysphoric disorder (PMDD), on sexual satisfaction, sexual distress, and sexual behaviors has not yet been established. Aims To assess the correlates and risk factors of sexual satisfaction and to evaluate sexual behaviors among Polish women with premenstrual symptoms. Methods 2,500 females, aged 18 to 45 years, from the Upper Silesian region of Poland were eligible for the questionnaire-based, prospective population study. All the inclusion criteria were met by 1,540 women who constituted the final study group. The participants were further divided into two subgroups: PMS+ (749 females) and PMS− (791 healthy subjects). Two additional subgroups were created: PMDD+ encompassing 32 subjects diagnosed with PMDD, and PMDD− comprising 32 healthy women, matched to the PMDD+ females for age, marital status, education level, employment status, place of living, and body mass index. A multiple logistic regression analysis was performed to evaluate the influence of PMS on sexual satisfaction and adjust for potential confounders. Main Outcome Measure To evaluate risk factors for sexual dissatisfaction in a population of Polish females of reproductive age, diagnosed with PMS and PMDD. Results Women from the PMS+ group were less sexually satisfied than PMS− (77.73% vs. 88.66%, P = 0.001) and reported more sexual distress (28.65% vs. 15.24%, P = 0.001). There were no significant differences in sexual satisfaction between PMDD− and PMDD+. Sexual satisfaction correlated positively with a higher frequency of sexual intercourses and a higher level of education. The presence of PMS correlated negatively with sexual satisfaction, even after adjusting for potential confounders in the multivariate logistic regression model (odds ratio=0.48; confidence interval: 0.26–0.89; P = 0.02). Conclusions The presence of PMS is a risk factor for sexual dissatisfaction in Polish women of reproductive age.

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Differences in Free Estradiol and Sex Hormone-Binding Globulin in Women with and without Premenstrual Dysphoric Disorder

Abstract: Luteal phase concentrations of free E2, percent free E2, and SHBG differ significantly between women with and without PMDD.

Cited by 33 publications

References 32 publications

Emotion regulation in women with premenstrual dysphoric disorder

Emotion regulation in women with premenstrual dysphoric disorder

The impact of supervised weight loss and intentional weight regain on sex hormone binding globulin and testosterone in premenopausal women

Sexual Satisfaction in Females with Premenstrual Symptoms

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