Differences in Immunoglobulin G Glycosylation Between Influenza and COVID-19 Patients

Batinjan, Marina Kljaković-Gašpić; Petrović, Tea; Vučković, Frano; Hadžibegović, Irzal; Radovani, Barbara; Jurin, Ivana; Đerek, Lovorka; Huljev, Eva; Markotić, Alemka; Lukšić, Ivica; Trbojević‐Akmačić, Irena; Lauc, Gordan; Gudelj, Ivan; Čivljak, Rok

doi:10.1016/j.eng.2022.08.007

Cited by 8 publications

(3 citation statements)

References 35 publications

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“…Because IgG N-glycans can promote complement deposition and ADCC, the N-glycan profile could identify patients in a highly proinflammatory state and associated with a heightened risk for a cytokine storm. Other studies have confirmed a lower level of sialylation and galactosylation with a concomitant increase in agalactose content associated with hospitalized COVID-19 patients who did not survive [ 68 , 70 ].…”

Section: Igg N-glycans Altered During Infectious Diseasementioning

confidence: 91%

“…While a plethora of research focuses on the effect of influenza vaccination on serum IgG glycosylation and therapeutic IgG antibody glycosylation, there are few studies that examine the host IgG glycan response to a natural infection. One study looked at patients hospitalized for influenza infection and determined that the patient serum IgG N-glycosylation exhibited increased sialic acid while also decreasing core-fucose content [ 68 ]. The decreased fucosylation was associated with heightened ADCC while the increase in sialic acid was associated with antigen affinity maturation.…”

Section: Igg N-glycans Altered During Infectious Diseasementioning

confidence: 99%

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IgG N-glycan Signatures as Potential Diagnostic and Prognostic Biomarkers

2023

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IgG N-glycans are an emerging source of disease-specific biomarkers. Over the last decade, the continued development of glycomic databases and the evolution of glyco-analytic methods have resulted in increased throughput, resolution, and sensitivity. IgG N-glycans promote adaptive immune responses through antibody-dependent cellular cytotoxicity (ADCC) and complement activation to combat infection or cancer and promote autoimmunity. In addition to the functional assays, researchers are examining the ability of protein-specific glycosylation to serve as biomarkers of disease. This literature review demonstrates that IgG N-glycans can discriminate between healthy controls, autoimmune disease, infectious disease, and cancer with high sensitivity. The literature also indicates that the IgG glycosylation patterns vary across disease state, thereby supporting their role as specific biomarkers. In addition, IgG N-glycans can be collected longitudinally from patients to track treatment responses or predict disease reoccurrence. This review focuses on IgG N-glycan profiles applied as diagnostics, cohort discriminators, and prognostics. Recent successes, remaining challenges, and upcoming approaches are critically discussed.

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Section: Igg N-glycans Altered During Infectious Diseasementioning

confidence: 91%

Section: Igg N-glycans Altered During Infectious Diseasementioning

confidence: 99%

IgG N-glycan Signatures as Potential Diagnostic and Prognostic Biomarkers

2023

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“…The lack of a medical remedy and vaccine, as well as digital and print media coverage of COVID-19 mortality, infection rates, overcrowded hospitals, and other negative information regarding the pandemic all, add to the fear and anxiety. 4, 5 The WHO had also developed public health guidelines to handle any type of potential psychological concerns. The increased fear associated with the coronavirus which had resulted in people attempting suicide is of great concern.…”

Section: Introductionmentioning

confidence: 99%

Psychological Distress and Anxiety among Nursing Professionals with Fear of Infection of COVID-19 Omicron Variant: A Cross Sectional E-survey Study

Pandey

Sharma

2023

Nursing & Midwifery Research Journal

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Background Contagious diseases are recognized as the most serious risks to population health. Even with the breakthroughs in medicine, there are still substantial causes of mortality and illness. During the early aftermath of the virus outbreak, the mental health of healthcare workers was severely impacted. Stress and anxiety appeared in the early stages of the pandemic, while symptoms of sadness, psychophysiological, and post-traumatic stress appeared later and remained for a long period, resulting in substantial repercussions. Aim To observe the psychological distress and anxiety among nursing professionals with fear of infection from COVID-19 omicron variant. Methods In this online cross-sectional survey study a self-made questionnaire was distributed to 246 nurses across the country using a snowball sampling method. Among 246 participants 210 were males and 36 were females between 18 and 38 years of age. Results The results of the study support the notion that the nursing professionals face psychological distress and anxiety due to the COVID-19 omicron variant. Conclusions The study was conducted on nursing professionals who were working in the COVID-19 ward and suffering from more psychological distress and anxiety.

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