Differences in information content of ribonucleic acids from malignant tissues and homologous organs as expressed by their biological activities

DeCarvalho, Sergio; Rand, H. J.; Uhrick, J.R.

doi:10.1016/0014-4800(62)90012-6

Cited by 13 publications

(5 citation statements)

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“…The marrow contained fjo,l, myeloblasts. On Jan. 10,1962, the patient had ii posterior myocardial infarction (the third in 2 years) during which immunotherapy rv'is continued. Despite the daily administration of heparin, there were no bleeding episodes.…”

Section: Cancer March 1963mentioning

confidence: 99%

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Preliminary experimentation with specific immunotherapy of neoplastic disease in man.I. Immediate effects of hyperimmune equine gamma globulins

Carvalho

1963

Cancer

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Section: Cancer March 1963mentioning

confidence: 99%

“…After the gram of the left arm showed "melting" of the tumor. Oxygen therapy was discontinued after 10 days of treatment because of improvement in breathing. The skin lesions became sharply demarcated and progressively darker in color.…”

mentioning

confidence: 99%

Preliminary experimentation with specific immunotherapy of neoplastic disease in man.I. Immediate effects of hyperimmune equine gamma globulins

Carvalho

1963

Cancer

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“…After 48 h of incubation at room temperature the plates are read in a bacteria colony counter (American Optics) adapted by replacing the grid by a heat-absorbing glass plate and increasing the bulb wattage. The method to photograph the fresh plates is the same described before [17], Fixing and staining of the plates for permanent record are performed as recommended by C rowle [II].…”

Section: Concentration O F the Test Seramentioning

confidence: 99%

Detection of Neoantigens in the Serum of Patients with Active Neoplastic Diseases by the Absorption-Immunodiffusion Method

DeCarvalho¹

1973

Oncology

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Horse precipitating antibodies produced against antigens isolated from a large number of human tumors have revealed identical tumor associated antigens in the serum of many patients with active malignant disease but not in the serum of patients afflicted with a variety of disorders including infectious, inflammatory and autoimmune disease, or in the serum of healthy individuals, in persons bearing benign tumors or in the serum of cancer patients in clinical remission. In the first 791 coded serum samples studied by an absorption-immunodiffusion method, there was 97–34% consistency and accuracy, and a conditional probability for screening correctly of 86%. Intricate Ouchterlony patterns indicated complex antigenic composition and a relationship between different neoplasms. Although a common antigen could not be excluded, the presence of group specific and single tumor antigens was observed. Quantitation of antigens in the serum with view to a measure of tumor specific tolerance was attempted but no information was obtained to the moment to correlate the amount of tumor tissue with the amount of circulating tumor antigen. The value of this test in presymptomatic detection was not established at this time. It is recognized that a great deal of work is required to confirm the universal diagnostic validity as well as the clinical sensitivity of the method proposed for detecting tumor associated antigens in circulation. False positive results in sera of pregnant women are discussed in the light of recent findings on the relationship of fetal and neoantigens.

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“…That RNA of human cancer cells behaves in tissue cultures and rodent models differently from RNA from normal cells [16][17][18]; that it can produce neoplasms in rodents [19,20]; that under given circumstances RNA from normal, isodifferentiated cells can reverse the neoplastic state [21, 22a, b], and that, thus, cancer is not a hopelessly irreversible cell state [23], That cellular differential functions can be transferred from cell to cell via informational RNAs [24,25]; that reverse transcription is a reality [26], That viruses can be and frequently are passengers in human cancer cells. That herpes viruses are frequent dwellers of the same [27,28], and that some of them may probably become keys to the immunoprophylaxis of certain cancers.…”

Section: -mentioning

confidence: 99%

Cancer 1974: An Analytical Vademecum of Oncologic Relevance

DeCarvalho¹

1973

Oncology

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One quarter of a century of largely observing and modestly participating in the development of present understanding of cancer is translated into an analysis of the emerging data, the relevance of which withstood time and led to a coherent concatenation of concepts with fruitful clinical applications. From the integration of the relevant data an incomplete synthesis was construed. The hiatus of incompleteness points to the where(s) and what(s) of future developments.

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Differences in information content of ribonucleic acids from malignant tissues and homologous organs as expressed by their biological activities

Cited by 13 publications

References 1 publication

Preliminary experimentation with specific immunotherapy of neoplastic disease in man.I. Immediate effects of hyperimmune equine gamma globulins

Preliminary experimentation with specific immunotherapy of neoplastic disease in man.I. Immediate effects of hyperimmune equine gamma globulins

Detection of Neoantigens in the Serum of Patients with Active Neoplastic Diseases by the Absorption-Immunodiffusion Method

Cancer 1974: An Analytical Vademecum of Oncologic Relevance

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