Differences in kainate receptor involvement in hippocampal mossy fibre long-term potentiation depending on slice orientation

Sherwood, J. L.; Amici, Mascia; Dargan, Sheila; Culley, Georgia; Fitzjohn, Stephen M.; Jane, David E.; Collingridge, Graham L.; Lodge, David; Bortolotto, Zuner A.

doi:10.1016/j.neuint.2012.04.021

Cited by 14 publications

(14 citation statements)

References 49 publications

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“…With respect to KARs, the finding that ACET when applied alone had no effect on LTP is consistent with our observations in transverse slices but contrasts with our findings in parasagittal slices, where ACET fully blocked LTP (Dargan et al, ; Sherwood et al, ). Indeed, when using parasagittal brain slices, we have observed the block of LTP by six structurally distinct KAR antagonists over a 20,000‐fold concentration range (Jane et al, ).…”

Section: Discussionsupporting

confidence: 91%

“…These fEPSPs had an onset latency of 2-3 ms and a peak of 7-10 ms (Derrick and Martinez, 1994). (2S,2 0 R,3 0 R)-2-(2 0 ,3 0 -dicarboxycyclopropyl)glycine) (DCG-IV) was applied at the end of all MF experiments to confirm the absence of associational/commissural pathway contamination (Kamiya et al, 1996;Yeckel et al, 1999;Hagena and Manahan-Vaughan, 2010;Sherwood et al, 2012). The experiments where DCG-IV did not depress the fEPSP slope by at least 70% were excluded from any analysis, for the concern of contamination from another form of LTP.…”

Section: Electrophysiologymentioning

confidence: 99%

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An interchangeable role for kainate and metabotropic glutamate receptors in the induction of rat hippocampal mossy fiber long‐term potentiation in vivo

et al. 2015

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The roles of both kainate receptors (KARs) and metabotropic glutamate receptors (mGluRs) in mossy fiber long-term potentiation (MF-LTP) have been extensively studied in hippocampal brain slices, but the findings are controversial. In this study, we have addressed the roles of both mGluRs and KARs in MF-LTP in anesthetized rats. We found that MF-LTP could be induced in the presence of either GluK1-selective KAR antagonists or group I mGluR antagonists. However, LTP was inhibited when the group I mGluRs and the GluK1-KARs were simultaneously inhibited. Either mGlu1 or mGlu5 receptor activation is sufficient to induce this form of LTP as selective inhibition of either subtype alone, together with the inhibition of KARs, did not inhibit MF-LTP. These data suggest that mGlu1 receptors, mGlu5 receptors, and GluK1-KARs are all engaged during high-frequency stimulation, and that the activation of any one of these receptors alone is sufficient for the induction of MF-LTP in vivo. © 2015 The Authors Hippocampus Published by Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 91%

Section: Electrophysiologymentioning

confidence: 99%

An interchangeable role for kainate and metabotropic glutamate receptors in the induction of rat hippocampal mossy fiber long‐term potentiation in vivo

et al. 2015

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“…The trigger for pre-LTP at mossy fiber synapses involves kainate receptors (KARs) (Bortolotto et al, 1999; Contractor et al, 2011; Jane et al, 2009). Although the subtype of KAR involved may depend on the precise anatomical connection (Sherwood et al, 2012), in some cases there is a requirement for GluK1-containing KARs (Bortolotto et al, 1999). The transduction of pre-LTP involves activation of adenylyl cyclase (AC), production of cyclic adenosine 3′,5′-monophosphate (cAMP), and activation of protein kinase A (PKA) (Nicoll and Schmitz, 2005), and the expression of pre-LTP may involve hyperpolarization-activated cyclic nucleotide-gated (HCN) channels (Chevaleyre and Castillo, 2002; Mellor et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Coexistence of Two Forms of LTP in ACC Provides a Synaptic Mechanism for the Interactions between Anxiety and Chronic Pain

Koga

Descalzi

Chen

et al. 2015

Neuron

294

228

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SUMMARY Chronic pain can lead to anxiety and anxiety can enhance the sensation of pain. Unfortunately, little is known about the synaptic mechanisms that mediate these re-enforcing interactions. Here we characterized two forms of long-term potentiation (LTP) in the anterior cingulate cortex (ACC); a presynaptic form (pre-LTP) that requires kainate receptors and a postsynaptic form (post-LTP) that requires N-methyl-D-aspartate receptors. Pre-LTP also involves adenylyl cyclase and protein kinase A and is expressed via a mechanism involving hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. Interestingly, chronic pain and anxiety both result in selective occlusion of pre-LTP. Significantly, microinjection of the HCN blocker ZD7288 into the ACC in vivo produces both anxiolytic and analgesic effects. Our results provide a mechanism by which two forms of LTP in the ACC may converge to mediate the interaction between anxiety and chronic pain.

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“…There is a discordance amongst the studies that have examined LTP following MPTP lesion, which is most likely caused by different experimental approaches e.g. varying timeframes post-MPTP, different schedule of MPTP treatment, different protocol to induce LTP and different origins/orientations of the slices along the dorso-ventral axis of the hippocampus224748. No previous studies have differentiated between dHip and vHip22454647.…”

Section: Discussionmentioning

confidence: 99%

Pramipexole restores depressed transmission in the ventral hippocampus following MPTP-lesion

Castro-Hernández

Adlard

Finkelstein

2017

Sci Rep

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The hippocampus has a significant association with memory, cognition and emotions. The dopaminergic projections from both the ventral tegmental area and substantia nigra are thought to be involved in hippocampal activity. To date, however, few studies have investigated dopaminergic innervation in the hippocampus or the functional consequences of reduced dopamine in disease models. Further complicating this, the hippocampus exhibits anatomical and functional differentiation along its dorso-ventral axis. In this work we investigated the role of dopamine on hippocampal long term potentiation using D-amphetamine, which stimulates dopamine release, and also examined how a dopaminergic lesion affects the synaptic transmission across the anatomic subdivisions of the hippocampus. Our findings indicate that a 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine induced dopaminergic lesion has time-dependent effects and impacts mainly on the ventral region of the hippocampus, consistent with the density of dopaminergic innervation. Treatment with a preferential D3 receptor agonist pramipexole partly restored normal synaptic transmission and Long-Term Potentiation. These data suggest a new mechanism to explain some of the actions of pramipexole in Parkinson´s disease.

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Differences in kainate receptor involvement in hippocampal mossy fibre long-term potentiation depending on slice orientation

Cited by 14 publications

References 49 publications

An interchangeable role for kainate and metabotropic glutamate receptors in the induction of rat hippocampal mossy fiber long‐term potentiation in vivo

An interchangeable role for kainate and metabotropic glutamate receptors in the induction of rat hippocampal mossy fiber long‐term potentiation in vivo

Coexistence of Two Forms of LTP in ACC Provides a Synaptic Mechanism for the Interactions between Anxiety and Chronic Pain

Pramipexole restores depressed transmission in the ventral hippocampus following MPTP-lesion

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