Differences in large and small artery response to acute inhibition of nitric oxide synthase in human subjects

Gilani, M.; Alinder, C.; Kaiser, Daniel R.; Rajala, Scott; Bank, Alan J.; Cohn, Jay N.

doi:10.1016/s0895-7061(00)00664-6

Cited by 9 publications

(10 citation statements)

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“…It is possible that endothelial dysfunction may play a role and manifest early in life. The reduction in C 2 may reflect endothelial dysfunction at the smaller resistance vessels, since intravenous infusion of the NO synthase analogue NG‐nitro‐1‐arginine methyl ester (L‐NAME) into healthy subjects reduces C 2 and increases blood pressure without affecting C 1 29 . Women who have a MI and greater morbidity and mortality than men of the same age may lack a protective factor, such as estrogen normally present in women, especially since the gender difference in coronary outcome diminishes with age.…”

Section: Discussionmentioning

confidence: 99%

Gender Differences in Vascular Compliance in Young, Healthy Subjects Assessed by Pulse Contour Analysis

Winer¹,

Sowers²,

Weber³

2001

J of Clinical Hypertension

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Women have reduced C2 despite lower systolic blood pressure and pulse pressure and more favorable lipid and homocysteine levels. C2 is independent of height and is lower in subjects with parental dyslipidemia. These data indicate that female sex hormones have unexpected negative effects on small vessel compliance. They may help to explain why premenopausal women hospitalized for myocardial infarction have higher mortality rates than men of the same age.

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Section: Discussionmentioning

confidence: 99%

Gender Differences in Vascular Compliance in Young, Healthy Subjects Assessed by Pulse Contour Analysis

Winer¹,

Sowers²,

Weber³

2001

J of Clinical Hypertension

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“…Small artery stiffness influences reflected waves 12 that have been identified in late systole as a pressure augmentation but can also be detected in diastole as an oscillation in the pressure decay that exhibits a frequency and rate of decay. 13 Small artery compliance or stiffness is a marker for endothelial dysfunction that induces a functional change in the microcirculation 14,15 and is a predictor of adverse cardiovascular events. 16 Resting blood pressure may be elevated when small artery tone is increased, but exercise blood pressure becomes a more sensitive guide to the stiffness of the arterial system.…”

Section: Screening Methodologymentioning

confidence: 99%

Arterial Elasticity as Part of a Comprehensive Assessment of Cardiovascular Risk and Drug Treatment

2005

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Abstract-Early cardiovascular disease can be identified in asymptomatic individuals by noninvasive evaluation of functional and structural abnormalities of the vasculature and heart. These abnomalities are usually a consequence of endothelial dysfunction. A panel of 10 tests, including small and large artery elasticity, has been used as the basis for a screening system that provides a score of 0 to 20 as a guide to the severity of disease. Using that Rasmussen score allows for stratification of patients into low, intermediate, or high risk for progression to cardiovascular morbid events. This comprehensive screening can be performed efficiently in a single room with a single technician. The sensitivity and specificity of this screening system in predicting future cardiovascular events, its superiority to traditional risk factor assessment, and its potential to track the response to therapeutic interventions must be validated in long-term follow-up studies. (Hypertension. 2005;46:217-220.)

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“…The reduction in C 2 may reflect endothelial dysfunction at the smaller resistance vessels, since intravenous infusion of the nitric oxide synthase analogue, NG-nitro-1-arginine methyl ester (L-NAME), into healthy persons reduces C 2 and increases blood pressure without affecting C 1 [18]. Resnick et al [19] reported close correlations of both C 1 and C 2 with the stroke volume-pulse pressure ratio and of C 1 with MRI-determined aortic distensibility.…”

Section: Estimating Vascular Compliancementioning

confidence: 99%

The effect of antihypertensive drugs on vascular compliance

Winer

Weber

Sowers

2001

Current Science Inc

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Measurement of vascular compliance has assumed increasing importance as a marker of early disease of the vascular wall, a predictor of future vascular disease, and a way to monitor the effects of vasoactive agents on arterial wall stiffness. Vascular compliance can be estimated by several methods: measurement of the pulse pressure, or pulse pressure-stroke volume ratio; analysis of the systolic pulse wave augmentation index and the diastolic pulse wave contour; ultrasonic echo-tracking; and MRI. Because few comparative studies have been done, the physiologic significance of the measures of compliance obtained by each method is uncertain. Antihypertensive drugs may improve vascular compliance by reducing blood pressure, relaxing vascular smooth muscle, or promoting long-term effects on vascular smooth muscle and cardiomyocyte growth and remodeling. Angiotensin converting enzyme (ACE) inhibitors have been reported to improve vascular compliance in nearly all studies, suggesting a beneficial class effect independent of blood pressure reduction. Favorable changes in the vascular wall-lumen ratio of small vessels from subcutaneous gluteal biopsy specimens after treatment with ACE inhibitors and the persistence of improved vascular compliance after withdrawal of therapy indicate that these agents may produce long-term vascular remodeling. Although few studies have been done, angiotensin II receptor antagonists improve vascular compliance, possibly by blocking angiotensin II-mediated cell proliferation and increasing apoptosis via unopposed AT1 receptor stimulation. In contrast, calcium antagonists and beta-blockers have variable effects on vascular compliance, although beta-blockers with intrinsic sympathomimetic activity improve vascular compliance. Diuretics have little effect on vascular compliance beyond their blood pressure-lowering actions, except for spironolactone, which by improving vascular compliance may have contributed to the reduction in heart failure mortality seen in the Randomized Aldactone Evaluation Study.

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Differences in large and small artery response to acute inhibition of nitric oxide synthase in human subjects

Cited by 9 publications

References 0 publications

Gender Differences in Vascular Compliance in Young, Healthy Subjects Assessed by Pulse Contour Analysis

Gender Differences in Vascular Compliance in Young, Healthy Subjects Assessed by Pulse Contour Analysis

Arterial Elasticity as Part of a Comprehensive Assessment of Cardiovascular Risk and Drug Treatment

The effect of antihypertensive drugs on vascular compliance

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