Differences in men and women suffering from CRSwNP and AERD in quality of life

Bartosik, Tina; Liu, David T.; Campion, Nicholas J.; Villazala-Merino, Sergio; Janik, Stefan; Dahm, Valerie; Mueller, Christian A.; Vyskocil, Erich; Stanek, Victoria; Bangert, Christine; Eckl‐Dorna, Julia; Schneider, Sven

doi:10.1007/s00405-020-06418-5

Cited by 13 publications

(12 citation statements)

References 33 publications

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“…In our study the male to female ratio was 1:1.2, 18(45%) males, 22(55%) females. This is in accordance with the studies by Qamar S et al, Alshoabi SA, Bartosik TJ and Khan M, where the disease was found to be more prevalent in females as compared to males [7][8][9][10] .…”

Section: Discussionsupporting

confidence: 93%

The Correlation of Peripheral Blood Eosinophils with Allergic Nasal Polyps

Kashif¹,

Fateen²,

Chaudhary³

et al. 2021

PJMHS

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Aim: To observe the association of peripheral blood eosinophil percentage in patients with allergic nasal polyps. Design: Descriptive cross-sectional study Place and duration: Pathology Department of Bakhtawar Amin Medical & Dental Hospital, Multan from September 2020 to August 2021. Methodology: Blood samples of all the cases operated for nasal polyps in Bakhtawar Amin Trust Institute are drawn before surgery to look for eosinophils. Family and past history of allergy is recorded. Histopathology of all the operated specimen of nasal polyps is done and sample for eosinophil count is collected again in cases that proved to be allergic nasal polyps on microscopic examination to look for any alteration in eosinophil percentage in blood on excision of polyps. Results: Twenty nine out of forty (72.5) percent of patients with allergic nasal polyps reveal increase in peripheral blood eosinophil percentage that returned to normal in 26(65%) patient on excision of nasal polyps. Conclusion: The study disclosed a notable link between allergic nasal polyps and peripheral blood eosinophil percentage and this association is further enhanced by the fact that the blood eosinophil count returned to normal on removal of nasal polyps. Keywords: Allergic nasal polyps, peripheral blood eosinophilia, eosinophil count, atopy

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Section: Discussionsupporting

confidence: 93%

The Correlation of Peripheral Blood Eosinophils with Allergic Nasal Polyps

Kashif¹,

Fateen²,

Chaudhary³

et al. 2021

PJMHS

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“…11 Bartosik et al found no sex differences in QoL scores or nasal polyp prevalence at a single institution. 12 In contrast, Mendolia-Loffredo et al investigated sex differences in computed tomography (CT), endoscopy, and QoL at a single institution and stated that females had lower baseline and postoperative QoL scores. 13 Lal et al noted that females had better baseline CT Lund-Mackay scores but worse 22-item Sino-Nasal Outcome Test (SNOT-22) scores.…”

mentioning

confidence: 99%

“…Most prior clinical studies exhibit predominantly male enrollment, but recent research has emphasized epidemiologic and physiologic differences between male and female patients 11 . Bartosik et al found no sex differences in QoL scores or nasal polyp prevalence at a single institution 12 . In contrast, Mendolia‐Loffredo et al investigated sex differences in computed tomography (CT), endoscopy, and QoL at a single institution and stated that females had lower baseline and postoperative QoL scores 13 .…”

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confidence: 99%

Sex Differences in Presentation and Surgical Outcomes From a Prospective Multicenter Chronic Rhinosinusitis Study

Asokan

Mace

Rice

et al. 2022

Otolaryngol.--head neck surg.

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Objective Despite extensive research into chronic rhinosinusitis (CRS) epidemiology, presentation, and outcomes, there is scant knowledge on sex-specific differences. The objective of this study was to identify differences between male and female patients with CRS in baseline disease severity at presentation, choice for surgery vs continued medical treatment, and postoperative response. Study Design We evaluated data on demographic and health characteristics, clinical objective disease measures, and sinus-specific and general health patient-reported outcome measures. Setting Secondary analysis of prospective multicenter outcome study. Methods Comparison of cohort characteristics and baseline and postoperative measures was performed with a t test, chi-square test of independence, or Fisher exact test. Within-subject improvement was compared between sexes with a linear mixed model. Results Females reported worse quality of life on presentation and postsurgery, despite experiencing less severe disease by standard clinical measures. Overall, females and males showed similar within-subject improvement after surgery. However, certain quality of life domains and disease measures showed sex-specific improvement. Females demonstrated greater within-subject improvement in SF6D-derived health utility and the SNOT-22 ear and facial, psychological, and sleep subdomains, although this did not reach statistical significance for the overall cohort. Conclusion Incorporating data on sex-specific differences may be important to personalize CRS treatment decision making. The discordance between patient-reported and clinical measures in CRS has been demonstrated in other pathologies and appears to be exaggerated by sex. Biological and psychological bases for sex-specific differences in CRS manifestations are an intriguing topic for further research.

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“…9 Other authors, however, noted no differences in SNOT-20 scores between genders. 11 Evaluation using other patient health-related QoL measures (HRQOL) yield similar results. At least 1 study still found that women scored worse than men on the 36-Item Short Form Survey and EuroQol-5D (EQ-5D) (n = 93), 12 but Phillips et al in a larger study found no difference between men and women on the EQ-5D despite women in the same patient population reporting worse SNOT-22 scores (n = 500).…”

Section: Discussionmentioning

confidence: 75%

Gender Differences in Adults With Chronic Rhinosinusitis: A Scoping Review

Behnke,

Dundervill,

Al‐Asadi

et al. 2024

Otolaryngol.--head neck surg.

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ObjectiveGender differences in chronic rhinosinusitis (CRS) have been demonstrated in many studies over the last 15 years. The purpose of this scoping review is to investigate the current knowledge on gender differences in CRS and to analyze the gaps in the literature.Data SourcesA systematic search of PubMed, Cochrane Library, and Embase databases was performed.Review MethodsThis scoping review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta‐analyses Extension for Scoping Reviews (PRISMA‐ScR) guidelines. Studies that evaluated gender differences in CRS were included in the review.ResultsOf the 523 abstracts reviewed, a total of 23 studies met the criteria for inclusion. Articles consisted of retrospective and prospective cohort studies. They were divided into 3 categories based on whether they evaluated gender differences in (1) presentation and baseline quality of life, (2) pathophysiology, and/or (3) outcomes of treatment. Eleven studies addressed differences in presentation, 5 addressed differences in pathophysiology, and 10 dealt with differences in outcomes after surgical or medical management. Most of the studies showed worse baseline QoL secondary to CRS in women, with outcome of treatment being similar in both genders.ConclusionThe experience of CRS appears to vary between genders, with women experiencing a greater subjective burden of disease than men, though with similar outcomes after treatment. Further research is indicated, particularly involving the pathophysiology of CRS, to fully understand the underlying causes of these discrepancies.

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Differences in men and women suffering from CRSwNP and AERD in quality of life

Cited by 13 publications

References 33 publications

The Correlation of Peripheral Blood Eosinophils with Allergic Nasal Polyps

The Correlation of Peripheral Blood Eosinophils with Allergic Nasal Polyps

Sex Differences in Presentation and Surgical Outcomes From a Prospective Multicenter Chronic Rhinosinusitis Study

Gender Differences in Adults With Chronic Rhinosinusitis: A Scoping Review

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