Differences in mucosal reaction related to <i>Candida albicans</i> isolates

Allen, Carl M.; Beck, F. Michael

doi:10.1111/j.1600-0714.1987.tb00693.x

Cited by 29 publications

(18 citation statements)

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“…The palatal smears from the experimental infection yielded yeasts that were almost exclusively in the hyphal form, as in Candida-associated denture stomatitis (30,34). Also, a number of studies by others with the SpragueDawley rat model of oral candidiasis have detected colonization patterns and lesions that were similar to human lesions both microscopically and histologically (4,5). Earlier studies by Russell and Jones (156) and Jones et al (82) using a rat model also demonstrated that Candida carriage and infectivity in this animal are similar to those in humans.…”

Section: Need For and Clinical Relevance Of Animal Modelsmentioning

confidence: 93%

“…The same workers noted the distinct strain-related patterns of C. albicans infections on the dorsal lingual mucosa of immunocompetent rats (3,4). They showed that while some isolates produced lesions particularly on the posterior-dorsal lingual mucosa accompanied by flattening of the normal papillary architecture of the epithelium, another group failed to produce any mucosal lesions.…”

Section: Sprague-dawley Rat Modelmentioning

confidence: 95%

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Experimental Oral Candidiasis in Animal Models

2001

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Oral candidiasis is as much the final outcome of the vulnerability of the host as of the virulence of the invading organism. We review here the extensive literature on animal experiments mainly appertaining to the host predisposing factors that initiate and perpetuate these infections. The monkey, rat, and mouse are the choice models for investigating oral candidiasis, but comparisons between the same or different models appear difficult, because of variables such as the study design, the number of animals used, their diet, the differences in Candida strains, and the duration of the studies. These variables notwithstanding, the following could be concluded. (i) The primate model is ideal for investigating Candida-associated denture stomatitis since both erythematous and pseudomembranous lesions have been produced in monkeys with prosthetic plates; they are, however, expensive and difficult to obtain and maintain. (ii) The rat model (both Sprague-Dawley and Wistar) is well proven for observing chronic oral candidal colonization and infection, due to the ease of breeding and handling and their ready availability. (iii) Mice are similar, but in addition there are well characterized variants simulating immunologic and genetic abnormalities (e.g., athymic, euthymic, murine-acquired immune deficiency syndrome, and severe combined immunodeficient models) and hence are used for short-term studies relating the host immune response and oral candidiasis. Nonetheless, an ideal, relatively inexpensive model representative of the human oral environment in ecological and microbiological terms is yet to be described. Until such a model is developed, researchers should pay attention to standardization of the experimental protocols described here to obtain broadly comparable and meaningful data

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Section: Need For and Clinical Relevance Of Animal Modelsmentioning

confidence: 93%

Section: Sprague-dawley Rat Modelmentioning

confidence: 95%

Experimental Oral Candidiasis in Animal Models

2001

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“…Candidosis of the dorsal rat tongue has been reported by Allen et al (1983Allen et al ( , 1987Allen et al ( , 1989), Russel (1974, 1975) as a characteristic, clinically apparent, lesion in the gigant conical papillae region. This clinical lesion was observed in 70 %, and infection with Candida spp.…”

Section: Discussionmentioning

confidence: 95%

“…Thus, the clinical presentation of the disease could be influenced by any one of the several factors, such as host immune status, diet, salivary flow rate and salivary composition, endocrine disturbances, use of antibiotics or steroids, and the presence of dentures (Allen and Beck 1987). These factors are eliminated in experiment and also our animal model is a suitable tool for detection of pathogenicity of yeast microorganisms.…”

Section: Discussionmentioning

confidence: 99%

“…Each isolate was identified as C. albicans and C. krusei by means of microscopic appearance, colony morphology on Sabouraud's agar (fy Imuna, Slovakia) and CHROMagar Candida (Mast Diagnostica, France), chlamydospore formation, sugar assimilation and fermentation, and germ tube formation within 2 h after inoculation of the yeast phase into human serum with incubation at 37 °C (Allen and Beck 1987).…”

Section: Methodsmentioning

confidence: 99%

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