Differences in neural responses to reward and punishment processing between anorexia nervosa subtypes: <scp>A</scp>n f<scp>MRI</scp> study

Murao, Ema; Sugihara, Genichi; Isobe, Masanori; Noda, Tomomi; Kawabata, Michiko; Matsukawa, Noriko; Takahashi, Hidehiko; Murai, Toshiya; Noma, Satoshi

doi:10.1111/pcn.12537

Cited by 20 publications

(14 citation statements)

References 58 publications

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“…This is in line with a pilot study that showed no differences between eating disorder individuals and a comparison group on attention to cues signaling reward as measured with the same task [25]. Findings of the current study are also in line with an fMRI study showing no difference in brain activation in response to reward anticipation between individuals with AN and healthy women [43]. All in all, findings mostly seem to indicate that there is no difference between individuals with AN and noneating disordered comparisons in reward sensitivity.…”

Section: Plos Onesupporting

confidence: 91%

Heightened self-reported punishment sensitivity, but no differential attention to cues signaling punishment or reward in anorexia nervosa

et al. 2020

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This study examined whether adolescents with anorexia nervosa (AN) are more sensitive to punishment and less sensitive to reward than a non-eating disorder comparison group. Both self-report and performance measures were used to index reward and punishment sensitivity. Participants were adolescents with AN (n = 69) and an individually matched comparison group with healthy weight (n = 69). They completed the Behavioral Inhibition Scale/Behavioral Activation Scale and the Sensitivity to Punishment and Sensitivity to Reward Questionnaire to index self-reported reward and punishment sensitivity, and performed the Spatial Orientation Task to index attention to cues signaling reward and punishment. There was extremely strong evidence (BF 10 > 100), that adolescents with AN reported higher sensitivity to punishment than adolescents without an eating disorder. However, adolescents with AN did not differ from the comparison group on self-reported reward sensitivity, and attention to cues signaling reward or punishment. Adolescents with AN clearly show heightened punishment sensitivity, yet this was not paralleled by a heightened proneness to detect signals of punishment. An important next step would be to examine whether punishment sensitivity is a reliable risk factor for the development or maintenance of AN.

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Section: Plos Onesupporting

confidence: 91%

Heightened self-reported punishment sensitivity, but no differential attention to cues signaling punishment or reward in anorexia nervosa

et al. 2020

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“…Murao et al ., also observed heightened activations in the right posterior insula and the cingulate during the anticipation of losses ( i.e . punishment) in AN patients with binge-eating/purging subtypes compared to patients with restricting subtype and healthy controls [26]. This hypersensitivity to punishment has been further demonstrated in the context of social behavior, with one study identifying ventral striatum activation during rejection on a social-judgment task to be positively correlated with AN severity scores [27].…”

Section: Reward Processing Networkmentioning

confidence: 99%

Neural Network Alterations Across Eating Disorders: A Narrative Review of fMRI Studies

et al. 2018

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Findings on reward processing in both AN and BN patients point to the presence of altered sensitivity to salient food stimuli in striatal regions and to the possibility of hypothalamic inputs being overridden by top-down emotional-cognitive control regions. Additionally, innovative new lines of research suggest that increased activations in fronto-striatal circuits are strongly associated with the maintenance of restrictive eating habits in AN patients. Although significantly fewer studies have been carried out in patients with BN and BED, aberrant neural responses to both food cues and anticipated food receipt appear to occur in these populations. These altered responses, coupled with diminished recruitment of prefrontal cognitive control circuitry, are believed to contribute to the binge eating of palatable foods. Results from functional network connectivity studies are diverse, but findings tend to converge on indicating disrupted resting-state connectivity in executive networks, the default-mode network and the salience network across EDs.

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“…Since the publication of DSM‐IV in 1994, two subtypes of anorexia nervosa (AN) have been formally distinguished: restricting (ANR) and binge‐eating/purging (ANBP) (American Psychiatric Association, 2000). Existing research has found, with some consistency, that individuals with ANBP are more impulsive (Peat, Mitchell, Hoek, & Wonderlich, 2009; Waxman, 2009), experience higher rates of suicide attempts, self‐injurious behavior, and substance use (Peat et al, 2009; Peterson et al, 2016) and report more severe eating disorder psychopathology (De Young et al, 2013; Ekeroth, Clinton, Norring, & Birgegård, 2013; Lewis et al, 2019; Murao et al, 2017; Reas & Ro, 2018). By definition, the two subtypes also differ in certain manifestations of actual eating behavior.…”

Section: Introductionmentioning

confidence: 99%

A comparison of food‐based decision‐making between restricting and binge‐eating/purging subtypes of anorexia nervosa

Uniacke

Slattery

Walsh

et al. 2020

Intl J Eating Disorders

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Objective: By definition, restricting (ANR) and binge-eating/purging (ANBP) subtypes of anorexia nervosa (AN) differ in some manifestations of maladaptive eating behavior. This study aimed to determine whether the groups differ in the choices they make about what to eat, and whether there are differences in valuation related to food choice, using an experimental paradigm. Method: Inpatients with ANR (n = 40) and ANBP (n = 46) participated in a Food Choice Task. During the task, participants rated 76 food images for healthiness and tastiness, and choice preferences. Groups were compared in percent selection of high-fat and low-fat foods, value ratings of foods, and engagement of self-control in food choice. Results: There were no differences between AN subtypes in healthiness or tastiness ratings, or in tendency to limit choice of high-fat foods. There was no difference between the groups in measures of self-control in food choice. Discussion: Individuals with ANR and ANBP similarly manifest reduced choices of high-fat foods, with similar tendencies to undervalue the tastiness of high-fat foods. These results suggest that while individuals with ANR and ANBP differ across a range of clinical characteristics, the decision-making process associated with the maladaptive restriction of high-fat foods characteristic of AN is shared by both subtypes.

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Differences in neural responses to reward and punishment processing between anorexia nervosa subtypes: An fMRI study

Cited by 20 publications

References 58 publications

Heightened self-reported punishment sensitivity, but no differential attention to cues signaling punishment or reward in anorexia nervosa

Heightened self-reported punishment sensitivity, but no differential attention to cues signaling punishment or reward in anorexia nervosa

Neural Network Alterations Across Eating Disorders: A Narrative Review of fMRI Studies

A comparison of food‐based decision‐making between restricting and binge‐eating/purging subtypes of anorexia nervosa

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