Differences in Nutritional Status Between Very Mild Alzheimer's Disease Patients and Healthy Controls

Rikkert, Marcel G M Olde; Verhey, Frans R.J.; Sijben, John; Bouwman, Femke H.; Dautzenberg, Paul L. J.; Lansink, Mirian; Sipers, Walther; Asselt, D.Z.B. van; Hees, Anneke M.J. van; Stevens, Martijn; Vellas, Bruno; Scheltens, Philip

doi:10.3233/jad-131892

Cited by 80 publications

(64 citation statements)

References 64 publications

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“…Of the remaining 66, 51 irrelevant studies were excluded by reviewing the title and abstracts. A total of 15 full text articles [7][8][9][10][11][12][13][14][15][16][17][18][20][21][22] were thoroughly reviewed for their inclusion. Of these, 3 duplicate articles were excluded [20][21][22].…”

Section: Resultsmentioning

confidence: 99%

“…As an antioxidant it protects OS mediated cell damage through a series of selenoproteins mainly glutathione peroxidase (GPx) and selenoprotein P [2,6]. The results of the available studies on selenium levels in AD are inconsistent [7][8][9][10][11][12][13][14][15][16][17][18]. While some studies have shown that AD patients have lower selenium levels [7,9,10,14,16,17], others [8,[11][12][13]15,18] have contrariwise reported an increased or no change.…”

Section: Introductionmentioning

confidence: 91%

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A systematic review and meta-analysis of the circulatory, erythrocellular and CSF selenium levels in Alzheimer's disease: A metal meta-analysis (AMMA study-I)

Varikasuvu

Bukke

Dutt

et al. 2017

Journal of Trace Elements in Medicine and Biology

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

A systematic review and meta-analysis of the circulatory, erythrocellular and CSF selenium levels in Alzheimer's disease: A metal meta-analysis (AMMA study-I)

Varikasuvu

Bukke

Dutt

et al. 2017

Journal of Trace Elements in Medicine and Biology

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“…The rate of malnutrition and malnutrition risk is very high in patients with dementia. It is reported that the onset of poor nutrition may be even before classical symptoms of dementia (1,2). It is crucial to screen these patients for malnutrition because poor nutrition is associated not only with a faster progression of dementia but also with adverse health problems (2,6,9,10).…”

Section: Discussionmentioning

confidence: 99%

“…Even the early stage of AD is associated with certain micronutrient deficiencies and a worse nutritional state compared to healthy subjects (1). Furthermore, weight loss is associated with a rapid cognitive decline in community-dwelling patients with AD (2).…”

Section: Introductionmentioning

confidence: 99%

Malnutrition is associated with dementia severity and geriatricsyndromes in patients with Alzheimer disease

Yıldız¹,

Pekel²,

Tolgay³

et al. 2015

Turk J Med Sci

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Background/aim: Malnutrition is associated with increased morbidity and mortality in patients with Alzheimer disease (AD). In this study, we aimed to screen for malnutrition and geriatric syndromes and seek their associations in patients with AD. Materials and methods:The Mini Mental State Examination (MMSE), Mini Nutritional Assessment (MNA), Katz Activities of Daily Living (ADL), and Lawton Instrumental Activities of Daily Living (IADL) tests were applied. Mean daily oral fluid intake was assessed according to patients' and relatives' declarations.Results: Seventy-six patients with a mean age of 79 ± 7.4 years were included. Most of the patients had mild or moderate dementia. Malnutrition was associated with increased rates of hospitalization and falls, dysphagia, insomnia, agitation, delusions, hallucinations, immobility, and incontinence. A daily fluid intake of <1100 mL was associated with malnutrition risk. Multivariate linear regression analysis revealed independent correlations of lower MNA score with lower ADL score, lower daily oral fluid intake, lower MMSE score, and female sex. Conclusion:Dependency, inadequate fluid intake, advanced dementia stage, and female sex were independently associated with malnutrition. Malnutrition also seemed to be associated with sleep disturbances, psychological problems, immobility, falls, and increased hospitalization risk in these patients. Daily oral fluid intake may be a practical tool in the screening of malnutrition.

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“…Moreover, selenate treatment was shown to positively alter the phosphorylation status of key proteins involved in oxidative stress, energy metabolism and protein degradation in cellular model of AD as indicated in broad phosphoproteomics study. Apart from playing important roles in regulation of redox homeostasis, ATP generation, and misfolded proteins clearance, selenate-treatment also resulted in reduction of homocysteine, phospho-tau as well as Aβ levels [129].…”

Section: Alzheimer's Diseasementioning

confidence: 99%

Selenium in the therapy of neurological diseases. Where is it going?

Dominiak¹,

Wilkaniec²,

Wroczyński³

et al. 2015

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Selenium ( 34 Se), an antioxidant trace element, is an important regulator of brain function. These beneficial properties that Se possesses are attributed to its ability to be incorporated into selenoproteins as an amino acid. Several selenoproteins are expressed in the brain, in which some of them, e.g. glutathione peroxidases (GPxs), thioredoxin reductases (TrxRs) or selenoprotein P (SelP), are strongly involved in antioxidant defence and in maintaining intercellular reducing conditions. Since increased oxidative stress has been implicated in neurological disorders, including Parkinson's disease, Alzheimer's disease, stroke, epilepsy and others, a growing body of evidence suggests that Se depletion followed by decreased activity of Se-dependent enzymes may be important factors connected with those pathologies. Undoubtedly, the remarkable progress that has been made in understanding the biological function of Se in the brain has opened up new potential possibilities for the treatment of neurological diseases by using Se as a potential drug. However, further research in the search for optimal Se donors is necessary in order to achieve an effective and safe therapeutic income.

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Differences in Nutritional Status Between Very Mild Alzheimer's Disease Patients and Healthy Controls

Cited by 80 publications

References 64 publications

A systematic review and meta-analysis of the circulatory, erythrocellular and CSF selenium levels in Alzheimer's disease: A metal meta-analysis (AMMA study-I)

A systematic review and meta-analysis of the circulatory, erythrocellular and CSF selenium levels in Alzheimer's disease: A metal meta-analysis (AMMA study-I)

Malnutrition is associated with dementia severity and geriatricsyndromes in patients with Alzheimer disease

Selenium in the therapy of neurological diseases. Where is it going?

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