Differences in physicochemical properties to consider in the design, evaluation and choice between microparticles and nanoparticles for drug delivery

Otto, Daniel P.; Otto, Anja; Villiers, Melgardt M. de

doi:10.1517/17425247.2015.988135

Cited by 39 publications

(25 citation statements)

References 84 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[6][7][8] Particularly, the control of pore sizes of MSN is quite essential on account of the connement effects of pores on both the accessibility of incoming drugs and the release of already-loading drugs. As for drug loading, the pore size should usually be larger than the drug molecules to host the target drug inside the pore space.…”

Section: -3mentioning

confidence: 99%

Effects of pore size on in vitro and in vivo anticancer efficacies of mesoporous silica nanoparticles

Shen

Kong

et al. 2018

RSC Adv.

View full text Add to dashboard Cite

Mesoporous silica nanoparticles (MSN) have been widely applied for drug delivery systems. To investigate the effects of pore size on anticancer efficacies, MSN with different pore sizes but similar particle sizes and surface charges were synthesized via a microemulsion method. The pore structures of MSN were characterized by transmission electron microscopy (TEM), small-angle X-ray scattering (SAXS), and N 2 adsorption-desorption isotherms. Doxorubicin loaded MSN (DOX/MSN) were prepared and the minimum drug loading capacity was detected in DOX/MSN with a pore size of 2.3 nm (DOX/MSN2).DOX/MSN with a pore size of 8.2 nm (DOX/MSN8) showed a comparable drug loading amount in comparison with ones with a pore size of 5.4 nm (DOX/MSN5). In vitro drug release profiles showed that DOX/MSN5 could release DOX quickly and completely. Compared with DOX/MSN2 and DOX/MSN8, DOX/MSN5 showed the higher cellular uptake and nucleic concentration of DOX in QGY-7703 cells, which led to efficient cell-apoptosis induction and anti-proliferation effect, and thus the optimal in vivo anticancer activities. Taken together, these results highlighted the importance of pore size in anticancer efficacies, which would serve as a guideline in the rational design of MSN for cancer therapy.

show abstract

Section: -3mentioning

confidence: 99%

Effects of pore size on in vitro and in vivo anticancer efficacies of mesoporous silica nanoparticles

Shen

Kong

et al. 2018

RSC Adv.

View full text Add to dashboard Cite

show abstract

“…A substantial amount of literature has been published with respect to drug delivery to the reticuloendothelial system [83–88], the effects of varying size and shape of materials for targeted drug delivery [89–93], and trafficking of drugs at the intra- and extracellular level [94–96]. From a purely theoretical basis the highest level of drug loading in MΦs occurs when sparingly soluble drug crystals are loaded.…”

Section: Recent Animal Trials: Ex Vivo Modified Macrophagesmentioning

confidence: 99%

Macrophage-based cell therapies: The long and winding road

Lee

Kivimäe

Dolor

et al. 2016

Journal of Controlled Release

160

143

View full text Add to dashboard Cite

In the quest for better medicines, attention is increasingly turning to cell-based therapies. The rationale is that infused cells can provide a targeted therapy to precisely correct a complex disease phenotype. Between 1987 and 2010, autologous macrophages (MΦs) were used in clinical trials to treat a variety of human tumors; this approach provided a modest therapeutic benefit in some patients but no lasting remissions. These trials were initiated prior to an understanding of: the complexity of MΦ phenotypes, their ability to alter their phenotype in response to various cytokines and/or the environment, and the extent of survival of the re-infused MΦs. It is now known that while inflammatory MΦs can kill tumor cells, the tumor environment is able to reprogram MΦs into a tumorigenic phenotype; inducing blood vessel formation and contributing to a cancer cell growth-promoting milieu. We review how new information enables the development of large numbers of ex vivo generated MΦs, and how conditioning and gene engineering strategies are used to restrict the MΦ to an appropriate phenotype or to enable production of therapeutic proteins. We survey applications in which the MΦ is loaded with nanomedicines, such as liposomes ex vivo, so when the drug-loaded MΦs are infused into an animal, the drug is released at the disease site. Finally, we also review the current status of MΦ biodistribution and survival after transplantation into an animal. The combination of these recent advances opens the way for improved MΦ cell therapies.

show abstract

“…Then it could decrease antitumor drug accumulation in targeting tissue and weaken the antitumor activity [2]. In recent years, nanoscaled drug delivery system, such as polymeric micelles, had been concerned by many researchers, owing to its perfect targeting, good solubility, altering tissue distribution, and controlled release characteristics [3]. Amphiphilic copolymers can form nanoscaled micelles with core-shell structure in aqueous media via selfassembly [4,5].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Evaluation of Doxorubicin-Loaded Micelles Based on Glycyrrhetinic Acid Modified Gelatin Conjugates for Targeting Hepatocellular Carcinoma

Fan

Yan

et al. 2018

Journal of Nanomaterials

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) is one of the most prevalent fatal diseases and the incidence of HCC is increasing worldwide. Polymeric micelles with targeting groups have drawn great attention as carriers for drug delivery in HCC therapy. Herein, novel glycyrrhetinic acid modified gelatin (GA-GEL) conjugates with three substitution degrees were synthesized and characterized. Doxorubicin (DOX) was applied as a model drug. DOX-loaded GA-GEL (DOX/GA-GEL) micelles were prepared by an emulsionsolvent evaporation method. The mean diameters of DOX/GA-GEL micelles were in the range of 195-235 nm. The encapsulation efficiency of DOX/GA-GEL micelles was 63.6%-96.2%, and the loading content was 8.3%-12.5%. Drug release from DOX-loaded micelles exhibited a biphasic manner in phosphate buffer solution (PBS) at pH 7.4. DOX/GA-GEL could be efficiently accumulated into human liver cancer HepG2 cells. The IC 50 values of DOX/GA-GEL-2 and DOX⋅HCl in HepG2 cells were 0.33 and 0.66 g/mL, respectively. In vivo imaging analysis demonstrated that the fluorescence signals of DiR-labeled GA-GEL-2 micelles were mainly distributed in liver and H22 orthotopic tumor, indicating that GA-GEL had the liver-targeting activity. Compared to DOX⋅HCl, DOX/GA-GEL-2 exhibited better antitumor activity in H22 orthotopic mice. Therefore, these results indicated that GA-GEL could be used as carrier of hydrophobic drug for targeting HCC.

show abstract

Differences in physicochemical properties to consider in the design, evaluation and choice between microparticles and nanoparticles for drug delivery

Abstract: Ultimately, the choice between micro- and nanometer-sized delivery systems is not straightforward. However, if the fundamental differences in physical and chemical properties are considered, it can be much easier to make a rational choice of the appropriate drug delivery system size.

Cited by 39 publications

References 84 publications

Effects of pore size on in vitro and in vivo anticancer efficacies of mesoporous silica nanoparticles

Effects of pore size on in vitro and in vivo anticancer efficacies of mesoporous silica nanoparticles

Macrophage-based cell therapies: The long and winding road

Preparation and Evaluation of Doxorubicin-Loaded Micelles Based on Glycyrrhetinic Acid Modified Gelatin Conjugates for Targeting Hepatocellular Carcinoma

Contact Info

Product

Resources

About