Differences in plasma lipoprotein profiles between patients with chronic peripheral neuropathic pain and healthy controls: an exploratory pilot study

Jönsson, Mika; Bäckryd, Emmanuel; Jonasson, Lena; Gerdle, Björn; Ghafouri, Bijar

doi:10.1097/pr9.0000000000001036

Cited by 3 publications

(3 citation statements)

References 47 publications

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“…As reported in previously published papers [ 8 , 16 , 22 , 23 ], the nerve injury that was deemed to cause the neuropathic pain was classified using the International Classification of Diseases version 10 (ICD-10) (see Table 1 ). Four patients suffered from peripheral neuropathic pain projected to the upper extremity, and twelve from peripheral neuropathic pain projected to the lower extremity.…”

Section: Methodsmentioning

confidence: 99%

Cerebrospinal Fluid Metabolomics Identified Ongoing Analgesic Medication in Neuropathic Pain Patients

Bäckryd,

Thordeman,

Gerdle

et al. 2023

Biomedicines

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Background: Cerebrospinal fluid (CSF) can reasonably be hypothesized to mirror central nervous system pathophysiology in chronic pain conditions. Metabolites are small organic molecules with a low molecular weight. They are the downstream products of genes, transcripts and enzyme functions, and their levels can mirror diseased metabolic pathways. The aim of this metabolomic study was to compare the CSF of patients with chronic neuropathic pain (n = 16) to healthy controls (n = 12). Methods: Nuclear magnetic resonance spectroscopy was used for analysis of the CSF metabolome. Multivariate data analysis by projection discriminant analysis (OPLS-DA) was used to separate information from noise and minimize the multiple testing problem. Results: The significant OPLS-DA model identified 26 features out of 215 as important for group separation (R2 = 0.70, Q2 = 0.42, p = 0.017 by CV-ANOVA; 2 components). Twenty-one out of twenty-six features were statistically significant when comparing the two groups by univariate statistics and remained significant at a false discovery rate of 10%. For six out of the top ten metabolite features, the features were absent in all healthy controls. However, these features were related to medication, mainly acetaminophen (=paracetamol), and not to pathophysiological processes. Conclusion: CSF metabolomics was a sensitive method to detect ongoing analgesic medication, especially acetaminophen.

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Section: Methodsmentioning

confidence: 99%

Cerebrospinal Fluid Metabolomics Identified Ongoing Analgesic Medication in Neuropathic Pain Patients

Bäckryd,

Thordeman,

Gerdle

et al. 2023

Biomedicines

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“…Moreover, all patients had either previously used or were using opioids. None had tried capsaicine and one had tried topical lidocaine (no patient had dynamic mechanical allodynia) 21 . The use of concomitant medication including analgesics was also reported: paracetamol, NSAID, weak opioids, strong opioids, gabapentin, antidepressants, capsaicin, and topical medication.…”

Section: Patientsmentioning

confidence: 99%

An investigation of metabolome in blood in patients with chronic peripheral, posttraumatic/postsurgical neuropathic pain

Ghafouri

Thordeman

Hadjikani

et al. 2022

Sci Rep

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Neuropathic pain (NP) is a chronic pain condition resulting from a lesion or disease in the somatosensory nervous system. The aim of this study was to investigate the metabolome in plasma from patients with chronic peripheral, posttraumatic/postsurgical NP compared to healthy controls. Further, we aimed to investigate the correlation between pain intensity and the metabolome in plasma. The metabolic profile in plasma samples from 16 patients with chronic NP and 12 healthy controls was analyzed using a nuclear magnetic resonance spectroscopy method. Information about pain intensity, pain duration, body mass index (BMI), age, sex, and blood pressure were obtained through a questionnaire and clinical examination. Multivariate data analysis was used to identify metabolites significant for group separation and their correlation with pain intensity and duration, BMI, and age. We found 50 out of 326 features in plasma significantly contributing to group discrimination between NP and controls. Several of the metabolites that significantly differed were involved in inflammatory processes, while others were important for central nervous system functioning and neural signaling. There was no correlation between pain intensity and levels of metabolite in NP. These findings indicate that there seems to be peripheral/systemic differences in the metabolic profile between patients with chronic NP and healthy individuals.

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“…20 However, in-depth analyses are needed to advance the field, including for other clinical pain areas such as neuropathic and widespread pain. 22,31 Although several studies have established a link between OA and inflammatory mediators, there is limited evidence available regarding the identification of potential biological biomarkers that can predict postoperative pain. 20,24,50,60 In 2017, Jonsson et al 30 investigated inflammatory biomarkers in saliva, cerebrospinal fluid, and plasma, identifying important biomarkers in plasma correlated with neuropathic pain.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory biomarkers in patients with painful knee osteoarthritis: exploring the potential link to chronic postoperative pain after total knee arthroplasty—a secondary analysis

Giordano,

Ghafouri,

Arendt-Nielsen

et al. 2023

Pain

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Total knee arthroplasty (TKA) is the end-stage treatment of knee osteoarthritis (OA), and approximately 20% of patients experience chronic postoperative pain. Studies indicate that inflammatory biomarkers might be associated with pain in OA and potentially linked to the development of chronic postoperative pain after TKA. This study aimed to (1) evaluate preoperative serum levels of inflammatory biomarkers in patients with OA and healthy control subjects, (2) investigate preoperative differences of inflammatory biomarker profiles in subgroups of patients, and (3) compare subgroups of patients with and without postoperative pain 12 months after surgery. Serum samples from patients with OA scheduled for TKA (n = 127) and healthy participants (n = 39) were analyzed. Patients completed the Knee-injury-and-Osteoarthritis-Outcome-Score (KOOS) questionnaire and rated their clinical pain intensity using a visual analog scale (VAS) before and 12 months after TKA. Hierarchical cluster analysis and Orthogonal Partial Least Squares Discriminant Analysis were used to compare groups (patients vs control subjects) and to identify subgroups of patients in relation to postoperative outcomes. Difference in preoperative and postoperative VAS and KOOS scores were compared across subgroups. Twelve inflammatory markers were differentially expressed in patients when compared with control subjects. Cluster analysis identified 2 subgroups of patients with 23 proteins being significantly different (P < 0.01). The 12-months postoperative VAS and KOOS scores were significantly different between subgroups of patients (P < 0.05). This study identified differences in specific inflammatory biomarker profiles when comparing patients with OA and control subjects. Cluster analysis identified 2 subgroups of patients with OA, with one subgroup demonstrating comparatively worse 12-month postoperative pain intensity and function scores.

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Differences in plasma lipoprotein profiles between patients with chronic peripheral neuropathic pain and healthy controls: an exploratory pilot study

Abstract: Supplemental Digital Content is Available in the Text.Lipoprotein profiles were significantly different between patients with chronic peripheral neuropathic pain and healthy controls, indicative of ongoing systemic low-grade inflammation among the patients.

Cited by 3 publications

References 47 publications

Cerebrospinal Fluid Metabolomics Identified Ongoing Analgesic Medication in Neuropathic Pain Patients

Cerebrospinal Fluid Metabolomics Identified Ongoing Analgesic Medication in Neuropathic Pain Patients

An investigation of metabolome in blood in patients with chronic peripheral, posttraumatic/postsurgical neuropathic pain

Inflammatory biomarkers in patients with painful knee osteoarthritis: exploring the potential link to chronic postoperative pain after total knee arthroplasty—a secondary analysis

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