Differences in prognostic factors and patterns of failure between invasive micropapillary carcinoma and invasive ductal carcinoma of the breast: Matched case–control study

Yu, Jeong Il; Choi, Doo Ho; Park, Won; Huh, Seung Jae; Cho, Eun Yoon; Lim, Young Hyuk; Ahn, Jin-Hwan; Yang, Jung Hyun; Nam, Seok‐Jin

doi:10.1016/j.breast.2010.01.020

Cited by 62 publications

(65 citation statements)

References 23 publications

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“…15 Chen et al 16 concluded, from a large-scale, retrospective study of 636 IMPC cases and 297 735 cases of invasive breast cancer, that despite the higher propensity for LNM, IMPC had a 5-year disease-free survival and a 5-year overall survival comparable to IDC-NOS. Excitingly, the 5-year overall survival of patients with IMPC has recently improved remarkably (82.9%-89.8%), 7,14,16,17 which is at least partially due to the increasing awareness of the entity that results in timely diagnoses and appropriate clinical managements.…”

Section: Clinical Featuresmentioning

confidence: 99%

“…7,[14][15][16][17]23,24,[37][38][39][40][41][42][43] One study of 624 patients with IMPC revealed a poor prognosis in the patients who had a tumor lacking in estrogen receptor expression. 7 The status of the HER2/neu protein expression or gene amplification in IMPC is not consistent in literature.…”

Section: Immunophenotypementioning

confidence: 99%

“…Yu et al 17 reported that lymphatic vessels were highly permeable in IMPCs, which tend to have high lymphatic vessel density and increased VEGF-C expression. Another study also found that expression of tumor necrosis factor-a and its receptor TNFR-II were upregulated in IMPC more than in IDC-NOS, and the upregulation was associated with tumor angiogenesis and lymph node metastasis.…”

Section: Immunophenotypementioning

confidence: 99%

“…Understanding the mechanism of its metastasis is critical for intervening in the clinical course; if the key steps in the metastasizing can be identified, the tools can be designed to target those steps. Many relevant studies have expanded our knowledge of IMPC metastases, including the immunohistochemical studies 17,[45][46][47][48][49]51 and electron microscopic investigations 6,50 discussed above. Tumor-infiltrating lymphocytes (TILs) are generally believed to represent a defensive mechanism of the human body against tumors.…”

Section: Mechanism Of Metastasismentioning

confidence: 99%

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Invasive Micropapillary Carcinoma of the Breast: An Update

Yang¹,

Liu²,

Zhang³

et al. 2016

Archives of Pathology &Amp; Laboratory Medicine

107

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Context.-Invasive micropapillary carcinoma (IMPC) is a distinct variant of mammary carcinoma in which tumor cells are arranged in morulelike clusters devoid of fibrovascular cores and situated within empty stromal spaces. Identification of IMPC can be achieved by the assessment of morphologic features in conjunction with the characteristic ''inside-out'' staining pattern of epithelial membrane antigen and sialyl Lewis X highlighted by immunohistochemical analysis. Although recognizing micropapillary architecture is often not challenging, the criteria for distinguishing between mixed and pure IMPC remain imprecise. Some mucin-producing carcinomas can also have micropapillary histology, but there is no consensus on whether these tumors are variants of IMPC or mucinous carcinomas. The molecular genetic studies demonstrate that IMPCs have distinct molecular genetic profiles, supporting the theory that they constitute distinct pathologic entities. However, genomic analyses have not identified any specific genomic aberration that may explain the distinctive morphology and clinical behavior of IMPC.Objective.-To provide an overview on the current concepts in the diagnosis and pathogenesis of IMPC of the breast, incorporating recent molecular genetic advances and prognosis-based reclassification.Data Sources.-PubMed search and the cited references were reviewed.Conclusions.-The recent evolution of prognosis-based reclassification and molecular genetic advances has enhanced our knowledge of the pathogenesis of IMPC of the breast. Additional studies might reveal consistent molecular alterations that underlie the formation of the inside-out growth pattern, and they might elucidate the molecular mechanisms responsible for the unfavorable clinical behavior of IMPC.

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Section: Clinical Featuresmentioning

confidence: 99%

Section: Immunophenotypementioning

confidence: 99%

Section: Immunophenotypementioning

confidence: 99%

Section: Mechanism Of Metastasismentioning

confidence: 99%

See 2 more Smart Citations

Invasive Micropapillary Carcinoma of the Breast: An Update

Yang¹,

Liu²,

Zhang³

et al. 2016

Archives of Pathology &Amp; Laboratory Medicine

107

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“…There are histological subtypes with excellent prognosis: tubular carcinoma, cribriform carcinoma, adenoid-cystic carcinoma, pure mucinous carcinoma [16], as well as subtypes associated with a worse prognosis, frequently diagnosed in a metastatic stage: micropapillary carcinoma, inflammatory carcinoma, NST carcinoma, lobular carcinoma [16,29,30]. Our study revealed that, when present in association with heterogeneous primary tumours, axillary lymph node metastases may present heterogeneous histological types (in 33.33% of cases).…”

Section: Discussionmentioning

confidence: 99%

Original paper Multifocal/multicentric breast carcinomas showing intertumoural heterogeneity: a comparison of histological tumour type and Nottingham histological grade of primary tumour and lymph node metastasis

Boros¹,

Podoleanu²,

Georgescu³

et al. 2015

pjp

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Invasive micropapillary carcinoma of the breast has a better long‐term survival than invasive ductal carcinoma of the breast in spite of its aggressive clinical presentations: a comparison based on large population database and case–control analysis

Chen

Wang

et al. 2017

Cancer Medicine

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There are controversies in the comparison of overall survival between invasive micropapillary carcinoma of the breast (IMPC) and invasive ductal carcinoma (IDC). The objective of this study was to compare the long‐term survival outcome between non‐metastatic IMPC and IDC. The Surveillance, Epidemiology, and End Results database was searched to identify women with non‐metastatic IMPC and IDC diagnosed between 2001 and 2013. Comparisons of patient and tumor characteristics were performed using Pearson's chi‐square. The propensity score matching method was applied with each IMPC matched to one IDC. Breast cancer‐specific survival (BCSS) and overall survival (OS) were estimated using the Kaplan–Meier product limit method and compared across groups using the log‐rank statistic. Multivariate analysis was performed through Cox models. IMPC was presented with aggressive clinical presentations such as larger tumor, more positive lymph nodes, and more advanced stage compared with IDC. A higher rate of estrogen receptor (ER)/progesterone receptor (PR) positivity was also observed in IMPC. With a median follow‐up of 64 months, IMPC had a better BCSS (P = 0.031) and OS (P = 0.012) compared with IDC. In a case–control analysis IMPC was still an independent favorable prognostic factor for BCSS (HR = 0.410, P < 0.001, 95% CI: 0.293–0.572) and OS (HR = 0.497, P < 0.001, 95% CI: 0.387–0.637). In subgroup analysis, IMPC always showed a better survival outcome compared with IDC except in AJCC stage I and histologic grade I disease. IMPC has a better long‐term survival outcome compared with IDC in spite of its highly aggressive clinical presentation.

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Differences in prognostic factors and patterns of failure between invasive micropapillary carcinoma and invasive ductal carcinoma of the breast: Matched case–control study

Cited by 62 publications

References 23 publications

Invasive Micropapillary Carcinoma of the Breast: An Update

Invasive Micropapillary Carcinoma of the Breast: An Update

Original paper Multifocal/multicentric breast carcinomas showing intertumoural heterogeneity: a comparison of histological tumour type and Nottingham histological grade of primary tumour and lymph node metastasis

Invasive micropapillary carcinoma of the breast has a better long‐term survival than invasive ductal carcinoma of the breast in spite of its aggressive clinical presentations: a comparison based on large population database and case–control analysis

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