2013
DOI: 10.1111/j.1742-1241.2012.03014.x
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Differences in prostate cancer detection rates according to the level of glomerular filtration rate in patients with prostate specific antigen levels of 4.0-10.0 ng/ml

Abstract: Because of the increased cancer detection rates in patients with CKD of stage ≥ 3 whose tPSA levels are 4.0-10.0 ng/ml, performing prostate biopsy should be actively considered in patients with CKD.

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“…It is possible that renal function could influence the pathophysiology of prostate cancer. Chronic kidney disease is common, with a prevalence of approximately 5–15% in the general population in most developed countries [ 3 , 4 ].Even minor changes in the glomerular filtration rate can lead to a significantly higher risk of experiencing complications such as cardiovascular disease [ 5 ], infections [ 6 ], anemia [ 7 ], bone fractures [ 8 ], and possibly cancer. Renal dysfunction leads to the retention of metabolic waste and the disruption of several signaling pathways associated with cancer, including those involved with the regulation of the immune system [ 9 , 10 ], inflammation [ 11 ], and vascular endothelial cell abnormalities [ 12 ].…”
Section: Introductionmentioning
confidence: 99%
“…It is possible that renal function could influence the pathophysiology of prostate cancer. Chronic kidney disease is common, with a prevalence of approximately 5–15% in the general population in most developed countries [ 3 , 4 ].Even minor changes in the glomerular filtration rate can lead to a significantly higher risk of experiencing complications such as cardiovascular disease [ 5 ], infections [ 6 ], anemia [ 7 ], bone fractures [ 8 ], and possibly cancer. Renal dysfunction leads to the retention of metabolic waste and the disruption of several signaling pathways associated with cancer, including those involved with the regulation of the immune system [ 9 , 10 ], inflammation [ 11 ], and vascular endothelial cell abnormalities [ 12 ].…”
Section: Introductionmentioning
confidence: 99%